Breast cancer: news in diagnosis and treatment

Nazário, Afonso Celso Pinto; Facina, Gil; Filassi, José Roberto

doi:10.1590/1806-9282.61.06.543

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…13 Segundo estudo, os principais fatores para o desenvolvimento do câncer de mama estão relacionados ao sistema reprodutivo, principalmente a menarca precoce, menopausa tardia, a nuliparidade, oligoparidade, assim como a primeira gestação tardia. 14 Conforme estudo com dados de 47 investigações epidemiológicas em 30 países, o risco de desenvolver câncer de mama diminui com o aumento da duração da amamentação, sendo esta redução de 4,5% para cada ano de amamentação. Já nos casos das mulheres nulíparas, considerando que estas não se beneficiarem do efeito protetor que é a amamentação, orienta-se e estimula-se para que adotem hábitos saudáveis visando a prevenção de fatores de risco que estão associados ao desenvolvimento desta neoplasia.…”

Section: Discussionunclassified

Caracterização de pacientes em tratamento radioterápico a partir da consulta de enfermagem

et al. 2017

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RESUMO: Objetivo: caracterizar o perfil sociodemográfico e clínico de pacientes em tratamento radioterápico, a partir da consulta de enfermagem. Método: estudo quantitativo, do tipo exploratório descritivo realizado em um ambulatório de radioterapia, com 60 pacientes em tratamento radioterápico, com idade igual ou superior a 18 anos. A coleta de dados ocorreu nos meses de junho e julho de 2015 e foram analisados por estatística descrita. Resultados: a maioria dos pacientes foi do sexo feminino, com idade entre 50 e 79 anos, com ensino fundamental completo, casados e com 1 a 3 filhos, sendo o câncer de mama em mulheres e o de próstata em homens, os mais incidentes. Considerações finais: a consulta de enfermagem mostrou-se uma estratégia de trabalho eficiente. O estudo pode contribuir para a elaboração de protocolos assistenciais que possibilitam qualificar o cuidado prestado. Descritores: Enfermagem; Oncologia; Radioterapia.ABSTRACT: Aim: to characterize the sociodemographic and clinical profile of patients in radiotherapical treatment from the nursing consultation. Method: this is a quantitative, descriptive exploratory study carried out in a radiotherapy outpatient clinic, with 60 patients undergoing radiotherapy treatment aged 18 years or older. The data analysis was made through descriptive statistics and its collection occurred during June and July 2015.Results: the majority of the patients were female, aged between 50 and 79 years old, with complete primary education, married and with 1 to 3 children. The most incidental outcomes were breast cancer in women and prostate cancer in men. Final considerations: nursing consultation proved to be an efficient work strategy. The study can contribute to the elaboration of assistance protocols that allows qualifying the care provided.

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Section: Discussionunclassified

Caracterização de pacientes em tratamento radioterápico a partir da consulta de enfermagem

et al. 2017

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“…e clinical management of breast cancer involves the use of selective estrogen receptor modulators like tamoxifen and fulvestrant (for hormonal therapies), aromatase inhibitors like anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara), CAR-T therapy, cytotoxic antibiotics such as atezolizumab (Tecentriq) and sacituzumab govitecan-hziy (Trodelvy), and, in certain conditions, the surgical removal of tumors such as lumpectomy (sentinel node biopsy) or partial mastectomy associated with radiation therapy to minimize recurrences [14][15][16]. However, these therapies remain unsatisfactory because of the high cost of treatments, their side effects, recurrences, and resistance of cancer cells to treatment.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibited Tumor Growth in Female Wistar Rats with 7,12-Dimethylbenz[a]anthracene-Induced Breast Cancer

Mvondo

Kamgaing

Ngnokam

2021

Evidence-Based Complementary and Alternative Medicine

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Breast cancer is the most common estrogen-dependent cancer in the world. Hormone therapy for this cancer can be neoadjuvant and/or adjuvant. Herbal remedies with antiproliferative properties are believed to be potential anticancer agents. The aqueous extract of Dacryodes edulis (Burseraceae) leaves (AE), a medicinal plant used against cancer in Cameroon, was found to display antiproliferative effects in ovariectomized rats. Compounds isolated from this plant exhibited anticancer activity in vitro. To determine whether AE has an anticancer potential, its effects were investigated in rats with already developed breast cancer. Mammary tumors were induced by a single subcutaneous administration (under the mammary gland) of 7,12-dimethylbenz[a]anthracene (DMBA; 50 mg/kgBW) to immature female rats. After 22–26 weeks of observation, animals with palpable tumors were treated with tamoxifen (3.3 mg/kgBW) and AE at doses of 25 and 100 mg/kgBW. The negative control received distilled water. Treatments were given orally for 21 consecutive days. The volume of mammary tumors was evaluated weekly using a caliper. On day 22, animals were sacrificed. Cholesterol and estradiol levels were assessed in serum, breast tumors, mammary glands, and ovaries. Oxidative status of tumors was evaluated. The histological analysis of mammary glands and breast tumors was performed. Results showed that AE reduced tumor volume and weight ( p < 0.05 ). This effect was associated with reduced cholesterol ( p < 0.001 ) and estradiol ( p < 0.01 ) levels in breast tumors, serum, ovaries, and mammary glands. AE also increased tumors levels of malondialdehyde ( p < 0.05 ) and antioxidant enzymes ( p < 0.01 ). These effects contributed to the decrease in the size of breast alveoli ( p < 0.01 ), the density of cancer cells in breast tumors, and the invasion of these cells into the tumor connective tissue. In conclusion, the aqueous extract of D. edulis leaves, thanks to its ability to inhibit tumor growth, could be considered as a potential alternative for the neoadjuvant treatment of estrogen-dependent breast cancer.

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“…There are different types of BC; the histological subtypes including ductal carcinoma and lobular carcinoma. Both ductal and lobular carcinoma may be either insitu or invasive (when it invades the surroundings) (Nazário, Facina et al 2015). Also the molecular subtypes includes; ER + and ERaccording to the status of estrogen receptors (ER) (Sotiriou, Neo et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of doxorubicin treatment at the expression levels of BCL-2 and BAX on MCF7 cell line

Awwad

El-Sharawy

Ashour

2018

The Arab Journal of Scientific Research

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Breast cancer (BC) is a chemotherapy sensitive tumor. Doxorubicin hydrochloride (DOX) is one of the most common chemotherapeutic drugs that used in breast cancer treatment. It intercalates with DNA and stops the replication process. And it was found that, following 48h of DOX treatment, cell death Increases in ER + breast cancer cell lines. Here we investigated the effect of DOX treatment at the antiapoptotic BCL-2 and the proapoptotic BAX genes.Methods: MCF7 cell line was cultured in the appropriate media and treated with DOX for 48 hours. Then the expression levels of BCL-2 and BAX were investigated using qPCR. Results: the expression of BCL-2 showed a slight increase in its levels after treatment while BAX gene showed a striking increase (3.62 fold). Conclusion: our results was in line with previous studies showed that treatment with DOX induce apoptosis in MCF7 cells.

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Breast cancer: news in diagnosis and treatment

Abstract: The authors discuss the main innovations in the diagnosis and treatment of breast cancer, particularly in diagnostic imaging and screening, and in locoregional and systemic therapies.

Cited by 9 publications

References 19 publications

Caracterização de pacientes em tratamento radioterápico a partir da consulta de enfermagem

Caracterização de pacientes em tratamento radioterápico a partir da consulta de enfermagem

Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibited Tumor Growth in Female Wistar Rats with 7,12-Dimethylbenz[a]anthracene-Induced Breast Cancer

Effect of doxorubicin treatment at the expression levels of BCL-2 and BAX on MCF7 cell line

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