Elevated serum osteoprotegerin levels in women: friend or foe?

Sasso, Gisela Rodrigues da Silva; Florencio‐Silva, Rinaldo; Simões, Ricardo Santos; Baracat, Maria Cândida Pinheiro; Júnior, José Maria Soares; Baracat, Edmund Chada

doi:10.1590/1806-9282.61.06.524

Cited by 9 publications

(7 citation statements)

References 54 publications

(58 reference statements)

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“…With regard to OPG, it is a cytokine member of the TNF receptor superfamily that binds to two ligands, the receptor activator of nuclear factor kappa-B ligand (RANKL), a key cytokine for the differentiation of osteoclasts, and a ligand related to the induction of apoptosis (TRAIL), involved in immune surveillance. Although clinical results confirm that OPG is an active cytokine in a wide range of diseases (osteoporosis, arthritis, vascular calcification, bone cancer related disease; Sasso et al, 2015 ), there are still conflicting results regarding OPG and exercise. For example, Pereira et al ( 2013 ) showed that an acute resistance training session (3 sets of 10 repetitions in whole body exercises with 60% of 1RM) induced no additional increase in pro-inflammatory cytokines nor a decrease in anti-inflammatory cytokines and OPG (measured before, immediately post and 60 min after exercise) in women with or without Metabolic Syndrome.…”

Section: Discussionmentioning

confidence: 99%

Two Consecutive Days of Extreme Conditioning Program Training Affects Pro and Anti-inflammatory Cytokines and Osteoprotegerin without Impairments in Muscle Power

Tibana

Almeida

Sousa³

et al. 2016

Front. Physiol.

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The aim of this study was to investigate the effects of two consecutive extreme conditioning program training sessions (24 h apart) designed to enhance work-capacity that involved both cardiovascular and muscular exercises on cytokines, muscle power, blood lactate and glucose. Nine male members of the extreme conditioning community (age 26.7 ± 6.6 years; body mass 78.8 ± 13.2 kg; body fat 13.5 ± 6.2%; training experience 2.5 ± 1.2 years) completed two experimental protocols (24 h apart): (1) strength and power exercises, (2) gymnastic movements, and (3) metabolic conditioning as follows: 10 min of as many rounds as possible (AMRAP) of 30 double-unders and 15 power snatches (34 kg). The same sequence as repeated on session 2 with the following metabolic conditioning: 12 min AMRAP of: row 250 m and 25 target burpees. Serum interleukin-6 (IL-6), IL-10, and osteoprotegerin were measured before, immediately post and 24 h after workout of the day (WOD) 1, immediately post, 24 and 48 h after WOD 2. Peak and mean power were obtained for each repetition (back squat with 50% of 1 repetition maximum) using a linear position transducer measured before, immediately post and 24 h after WOD 1, immediately post and 24 h after WOD 2. Blood lactate and glucose were measured pre and immediately post WOD 1 and 2. Although both sessions of exercise elicited an significant increase in blood lactate (1.20 ± 0.41 to 11.84 ± 1.34 vs. 0.94 ± 0.34 to 9.05 ± 2.56 mmol/l) and glucose concentration (81.59 ± 10.27 to 114.99 ± 12.52 vs. 69.47 ± 6.97 to 89.95 ± 19.26 mg/dL), WOD 1 induced a significantly greater increase than WOD 2 (p ≤ 0.05). The training sessions elicited significant changes (p ≤ 0.05) in IL-6, IL-10 and osteoprotegerin concentration over time. IL-6 displayed an increase immediately after training WOD 1 [197 ± 109%] (p = 0.009) and 2 [99 ± 58%] (p = 0.045). IL-10 displayed an increase immediately after only WOD 1 [44 ± 52%] (p = 0.046), and decreased 24 and 48 h following WOD 2 (~40%; p = 0.018) as compared to pre-exercise values. Osteoprotegerin displayed a decrease 48 h following WOD 2 (~25%; p = 0.018) as compared with pre intervention. In conclusion, two consecutive extreme conditioning training sessions increase pro/anti-inflammatory cytokines with no interference on muscle performance in the recovery period.

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Section: Discussionmentioning

confidence: 99%

Two Consecutive Days of Extreme Conditioning Program Training Affects Pro and Anti-inflammatory Cytokines and Osteoprotegerin without Impairments in Muscle Power

Tibana

Almeida

Sousa³

et al. 2016

Front. Physiol.

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“…OPG is likely to be stimulated by proinflammatory cytokines. Elevated TNF-α and IL-6 levels are strongly associated with OPG levels (27). TNF-α and IL-6 enhance bone resorption; therefore, their association with OPG suggests a protective effect of raised OPG on bone loss.…”

Section: Discussionmentioning

confidence: 99%

Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis

Prystupa¹,

Dabrowska²,

Sak³

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to evaluate the concentrations of fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages of the disease, and to demonstrate that fetuin-A, osteoprotegin and α-Klotho may be used as markers of the severity of cirrhosis. A total of 54 patients with alcoholic liver cirrhosis treated in various hospitals in the Lublin region of Poland were randomly enrolled. The control group consisted of 18 healthy individuals without liver disease, who did not drink alcohol. Serum levels of fetuin-A, OPG and α-Klotho were measured by ELISA kits. Levels of fetuin-A were significantly reduced in patients with alcoholic liver cirrhosis compared with the control group. OPG levels were higher in patients with alcoholic liver cirrhosis than in the controls, whereas the levels of α-Klotho were comparable in the cirrhosis and control groups. No statistically significant differences in the concentrations of fetuin-A, OPG and α-Klotho protein were demonstrated according to type of liver cirrhosis. The findings of the present study revealed a significant negative correlation between the level of α-Klotho protein and C-reactive protein in the patients with alcoholic liver cirrhosis. Concentrations of fetuin-A were lower, whereas those of OPG were higher, in the alcoholic liver cirrhosis group compared with the control group. Fetuin-A, OPG and α-Klotho may not be good indicators of liver cirrhosis severity. In conclusion, fetuin-A and OPG may be used in the diagnosis of liver cirrhosis.

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“…However, the protective role of OPG found in the animal model has not been observed in humans. In contrast, in humans many authors suggest a positive association between serum OPG and atherosclerosis, arterial calcification, or CV disease [24]. High serum concentrations of OPG were correlated to the severity of peripheral arterial disease [25] and heart failure [26], unstable angina [27], acute myocardial infarction and risk of death [28].…”

Section: Discussionmentioning

confidence: 98%

Effects of 17β-estradioland raloxifene on endothelial OPG and RANKL secretion

Karwowski¹,

Lekesiz²,

Koc-Żórawska³

et al. 2017

Ginekol Pol

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Objectives: This study aims to asses the effects of estradiol vs. raloxifene on the levels of osteoprotegerin and soluble Receptor Activator of Nuclear Factor kB Ligand (sRANKL) in Human Umbilical Vein Endothelial Cells (HUVEC) culture in standard and calcifying medium. Material and methods:Human Umbilical Vein Endothelial Cells were isolated from human umbilical vein by standard method. The supernatant concentrations of osteoprotegerin (OPG) and sRANKL (ELISA) were determined after incubation with glicerophosphate, estradiol , raloxifene, glicerophoshate and estradiol, glicerophosphate and raloxifene in comparison with control group at four designated time points (0, 1, 2 and 4 days of incubation).Results: Incubation of estradiol with HUVEC colony lowered the OPG level significantly after day 2 and 4. Meantime, the level of sRANKL was stable. Raloxifene added to standard growth medium also significantly lowered OPG concentration after day 4 only, with no impact on sRANKL concentration. When added to calcifying medium, both estradiol and raloxifene significantly changed OPG level during the experiment. In all treated groups OPG levels were lower than in groups exposed to calcifying medium only. Neither estradiol, nor raloxifene changed sRANKL levels during the experiment. Conclusions:Estradiol and raloxifene affect OPG secretion from endothelial cells in vitro which may suggest their modifying role in pathogenesis of vascular calcification in postmenopausal women.

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Elevated serum osteoprotegerin levels in women: friend or foe?

Abstract: SaSSo GRS et al. 524rev assoC Med Bras 2015; 61(6):524-529

Cited by 9 publications

References 54 publications

Two Consecutive Days of Extreme Conditioning Program Training Affects Pro and Anti-inflammatory Cytokines and Osteoprotegerin without Impairments in Muscle Power

Two Consecutive Days of Extreme Conditioning Program Training Affects Pro and Anti-inflammatory Cytokines and Osteoprotegerin without Impairments in Muscle Power

Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis

Effects of 17β-estradioland raloxifene on endothelial OPG and RANKL secretion

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