In-hospital mortality risk factors in patients with ascites due to cirrhosis

Abstract

Conflict of interest: noneIntroduction: ascites is one of the most common complications of cirrhosis associated with a high rate of mortality. Although several scores have been developed in order to assess the prognosis of the disease, they were designed for predicting liver transplantation requirements and mortality in the short term, but not while in hospital. The aim of this study was to weigh risk factors for in-hospital mortality in adult patients with ascites due to alcoholic cirrhosis. Material and methods: we performed a cross-sectional study in 180 adult patients with diagnosis of cirrhosis with portal hypertension associated with high alcohol intake. The diagnosis of cirrhosis was made by liver echography and portal hypertension was defined by clinical features plus serum-ascites albumin gradient. Sampled individuals were subjected to complete clinical examination. Child Pugh and the MELD scores were applied in all the patients. Results: nineteen patients died while in-hospital. Mortality was associated with increased levels of serum white blood cell, urea, creatinine, prolonged prothrombin time, aspartate aminotransferase and alanine aminotransferase. We conducted a multiple binary logistic to predict in-hospital mortality which yielded that serum urea, creatinine and prothrombin time made a significant contribution to prediction with an OR 14 (95% CI 12.8 -16.7 p = 0.03), 2 (95% CI 0.5 -3.47, p = 0.04), and 2 (95% CI 1.03 -2.31, p = 0.01) linearly-related. Conclusions: our results suggest that acute renal failure and prolonged prothrombin time are predictors of in-hospital mortality in patients with portal hypertension due to alcoholic cirrhosis.

Short-term clinical outcomes of patients admitted with chronic liver disease to selected teaching hospitals in Ethiopia

“…But, higher in-hospital mortality as compared to our finding was reported by two other studies [14,34]. On the other hand, lower in-hospital mortality was documented from Argentinean and Moroccan studies[35,36]. These discrepancies could be partly due to the difference in settings included.…”

“…In the present study, the hazard of in-hospital mortality was found to increase by more than eleven-fold among patients with hepatic encephalopathy at admission as compared to those not diagnosed with hepatic encephalopathy In line with this, studies have shown an increase in the risk of mortality among patients with hepatic encephalopathy at presentation[36,37]. Hepatic encephalopathy is associated with poor outcomes with an overall decline in liver function, increased risk of in-hospital and short-term mortality[38,39,40].…”

Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma

“…The MELD score predicts 90 days survival of patients with ESLD in the waiting list for LTx and predict postoperative complications after surgery of patients with liver disease 26, 27, 28, 29, 30. PCA and PLS-DA provided metabolic prints of patients with ESLD distributed by high or low MED scores.…”

Factors Associated with in-Hospital Mortality in Malagasy Patients with Acute Decompensation of Liver Cirrhosis: A Retrospective Cohort

“…Approximately 60% of cirrhotic patients will develop ascites within 10 years, which is a poor prognostic factor since the survival rate is 40% at 1 year. 8 Our results showed that hepatic encephalopathy (EH) was not only the first cause of mortality, but also appeared to be a risk factor for death during hospitalization (OR: 14.15; 95% CI: 5.08 to 39.43, p=0.000). In a Ghanaian study, including 167 cirrhotic patients, 53 patients had presented a HE of which 40 (75.5%) died during hospitalization.…”