Intake of antioxidants in patients with rheumatoid arthritis

Silva, Bruna Nolasco Siqueira; Araújo, Ísis Lucília Santos Borges de; Queiroz, Pedrita Mirella Albuquerque; Duarte, Ângela Luzia Branco Pinto; Burgos, Maria Goretti Pessôa de Araújo

doi:10.1590/1806-9282.60.06.014

Cited by 8 publications

(11 citation statements)

References 22 publications

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“…Cardiac glycosides showed to aid in treatment of congestive heart failure and cardiac arrhythmia. Free radicals are continuously produced in the human body, as they are essential for energy supply, detoxification, chemical signaling and immune function but they are also involved in various diseases such as diabetes [22] , rheumatoid arthritis [23][24] , high blood pressure [25] , urinary tract disorders [26] , bronchial asthma [27][28] and non-healing wounds [29] . Free radicals can initiate the oxidation of bio molecules, such as protein, lipid, amino acids and DNA which will lead to cell injury and can induce numerous diseases [30] .…”

Section: Discussionmentioning

confidence: 99%

Study of Phytochemical Constituents and Anti-oxidant Activity of Spinacia oleracea L. of Bundelkhand Region

Kumar¹,

Patwa²

2018

IJLSSR

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ABSTRACT-Background: Spinacia oleracea L. commonly known as palak is an edible flowering plant belongs toAmaranthaceae family. The plants exhibit its curative activity against several human diseases because of the presence of biological tannins and phenolic active phytochemicals such as alkaloids, flavonoids, steroids, glycosides, terpenoids. It is used in the treatment of difficulty in breathing, inflammation of liver and lungs and leucorrhoea, useful in urinary concretion, inflammation of the lungs, sore throat, and pain in joints. Materials and Methods: Spinacia oleracea L. was collected from local market Jhansi in the month of January 2017. Aqueous and methanolic extraction of Spinacia oleracea L. and phytochemical screening of the extracts was done for Saponins, Reducing sugar, Cardiac glycosides, Protein and Amino acid, Glycosides, Alkaloids, Tannins, Flavonoids, Terpenoids, and Steroids. Results: Phytochemical analysis of leaves of S. oleracea had most of the important phytochemicals like Alkaloids, Tannins, Glycosides, Terpenoids, and Flavonoids etc. In which, the aqueous extract of S. oleracea showed (in most of the test) positive result for Alkaloids, Phenols, Flavanoids, Saponins, Terpenoids, Reducing sugar, Protein, and Amino acid and showed a negative result for Carbohydrate, Glycosides, and Cardiac glycosides. The methanolic extract of the plant leaves revealed the presence of (in most of the test) Alkaloids, Tannins & Phenolic compounds, Flavanoids, Saponins, Terpenoids and Steroids and negative results for the rest. Conclusions:The phytochemical analysis of S. oleraceae revealed the presence of phytochemicals such as, Tannins, Flavonoids, Alkaloids, Saponins, and Terpenoids etc. in the different extracts. By the presence of these phytochemicals, we were suggested that S. oleracea is a good nutrient rich leafy vegetable that can be used as a therapeutic and curative medicine for many oxidative stress-induced diseases.

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Section: Discussionmentioning

confidence: 99%

Study of Phytochemical Constituents and Anti-oxidant Activity of Spinacia oleracea L. of Bundelkhand Region

Kumar¹,

Patwa²

2018

IJLSSR

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“…The study found no associations between risk of RA and other dietary factors including intake of fruit and coffee, long chain fatty acids, olive oil, vitamins A, E, C, D, zinc, selenium, iron, and meat. A small cross-sectional case series of 53 women with RA indicated that the patients overall had a low dietary consumption of vitamins A and C, and zinc, and in the elderly in particular there was low consumption of vitamin E and selenium ( Silva et al, 2014 ). In a survey study of a single-center RA registry, 24% of subjects reported that foods affect their RA, with 15% reporting improvement and 19% worsening ( Tedeschi et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Characteristics and risk factors of rheumatoid arthritis in the United States: an NHANES analysis

Lin

2017

PeerJ

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BackgroundWe examined the United States National Health and Nutrition Examination Survey (NHANES) database to determine factors associated with rheumatoid arthritis (RA) in adults 20 to 55 years of age.MethodsNHANES data collected between 2007 and 2014, excluding the 2011–2012 period, were used. Subjects were divided into those with and without RA. Demographic, clinical, and lifestyle factors were compared between the groups.ResultsAfter applying inclusion/exclusion criteria, 8,789 persons were included in the study (8,483 without RA, 306 with RA). Multivariable analysis indicated that advanced age (odds ratio [OR] = 1.09, 95% CI [1.07–1.11], P < 0.001), regular smoking (OR = 2.19, 95% CI [1.49–3.21], P < 0.001), diabetes (OR = 2.00, 95% CI [1.35–2.95], P = 0.001), obesity (reference, normal or underweight; OR = 3.31, 95% CI [2.05–5.36], P < 0.001), and osteoporosis (OR = 3.68, 95% CI [1.64–8.22], P = 0.002) were positively associated with RA. Covered by health insurance (OR = 1.81, 95% CI [1.12–2.93], P = 0.016) and living in poverty (OR = 2.96, 95% CI [1.88–4.65], P < 0.001) were also associated with having RA. Mexican American, Hispanic white or other Hispanic ethnicity (reference, non-Hispanic white; OR = 0.54, 95% CI [0.31–0.96], P = 0.036), appropriate sleep duration (about 6–11 h, OR = 0.46, 95% CI [0.32–0.65], P < 0.001), and insufficient vitamin A intake (reference, recommended; OR = 0.70, 95% CI [0.50–0.98], P = 0.036) were negatively associated with RA.DiscussionSome factors associated with RA are potentially modifiable.

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“…The continuous production of free radicals in inflamed joint gives rise to failure of antioxidant system and further tissue damages. Also the intake of food antioxidants is lower than the recommended amounts in RA patients (Silva et al, 2014). Reduced vitamin C level in RA patients was also reported by Jaswal et al (2003); Mateen et al (2016);and Vijayakumar et al (2006).…”

Section: Discussionmentioning

confidence: 65%

Evaluation of the effect of vitamin C on caspase 9 and oxidative stress in rheumatoid arthritis patients

Elshamy¹,

Gaafar²,

ElAshwah³

et al. 2018

Afr. J. Biochem. Res.

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Rheumatoid arthritis (RA) is a chronic and an autoimmune disease of the joints and is widely distributed worldwide. It is characterized by alterations of the antioxidant defense system and increased free radical formation and pro-inflammatory cytokine. The aim of the present study was to evaluate the effect of vitamin C supplementation on oxidative stress biomarkers and caspase 9 level in rheumatoid arthritis patients. This study included 30 RA patients and 30 healthy subjects. Plasma levels of malondialdehyde (MDA), total antioxidant capacity (TAC), caspase 9 and 8-hydroxy-2′deoxyguanosine (8 OHdG) were assayed as well as blood vitamin C level. These parameters were reevaluated in RA patients after vitamin C supplementation for one month. Increased MDA and 8 OHdG levels and reduced TAC, caspase 9 and vitamin C. Levels were demonstrated in RA patients. After vitamin C supplementation, RA patients showed significant increase in TAC and vitamin C level and significant decrease in MDA and 8 OHdG levels, plasma caspase 9 level was not significantly affected after vitamin C supplementation. Increased oxidative stress and decreased apoptosis may have an important role in the pathogenesis of RA. The administration of vitamin C supplementation may help to relieve oxidative stress and enhance the antioxidant defense in these patients.

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Intake of antioxidants in patients with rheumatoid arthritis

Cited by 8 publications

References 22 publications

Study of Phytochemical Constituents and Anti-oxidant Activity of Spinacia oleracea L. of Bundelkhand Region

Study of Phytochemical Constituents and Anti-oxidant Activity of Spinacia oleracea L. of Bundelkhand Region

Characteristics and risk factors of rheumatoid arthritis in the United States: an NHANES analysis

Evaluation of the effect of vitamin C on caspase 9 and oxidative stress in rheumatoid arthritis patients

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