Polycystic ovary syndrome in adolescents with obesity

Fu, Leyi; Qu, Fan; Pan, Jiexue; Wang, Tian; Wang, Fangfang

doi:10.1590/1806-9282.20200890

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Once the diagnosis of obesity has been made, it is vital to begin a holistic approach and show care for linked comorbidities as soon as feasible. Their weight condition substantially impacts the patient's pathophysiology [34]. The characteristic ovarian structure confirmed by ultrasound examination, elevated levels of luteinizing hormone, androgens, prolactin, and estradiol concentration with an upper limit are the distinguishing features of PCOS in addition to the clinical symptoms.…”

Section: Complicationsmentioning

confidence: 99%

Polycystic Ovarian Syndrome in Adolescents

Adone¹,

Fulmali²

2023

Cureus

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Polycystic ovarian syndrome (PCOS) is a metabolic, reproductive, and psychological complex series of disorders that impacts a woman throughout her lifespan. PCOS is a disorder of hormonal imbalance occurring in women of reproductive age. This disorder is characterized by high levels of male androgens like testosterone. This can lead to symptoms like irregular periods, amenorrhea (absence of menstruation), anovulation (absence of ovulation), hirsutism, acne, and obesity. PCOS also causes metabolic impairment. Multiple peripherally arranged immature follicles of about 2-5mm in diameter are present in the ovary. These follicles do not mature due to hormonal imbalances leading to an irregular menstrual cycle. PCOS is a metabolic, reproductive, and psychological complex series of disorders that impacts a woman throughout her lifespan. Polycystic ovarian syndrome is not a fatal or life-threatening disorder as its main complication is infertility. PCOS can be a root cause of serious medical conditions like obesity, hypertension, type-2 diabetes mellitus due to insulin resistance, endometrial cancers, ovarian cancer, etc. Stress may cause the hormone levels in the pituitary to fluctuate. Since the menstrual cycle is hormone-based, there are apparent irregularities.

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Section: Complicationsmentioning

confidence: 99%

Polycystic Ovarian Syndrome in Adolescents

Adone¹,

Fulmali²

2023

Cureus

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“…Sindrom ovarium polikistik (SOPK) adalah salah satu gangguan endokrin yang paling umum dan dapat ditemukan pada 5% -10% wanita usia reproduksi (Fu et al, 2021;Lauritsen et al, 2014). Hingga saat ini, penyebab SOPK masih belum jelas dan berbagai sumber telah menjelaskan bahwa penyebabnya adalah hasil interaksi kompleks antara faktor genetik dan lingkungan (Ndefo et al, 2013) (Kabel, 2016).…”

Section: Pendahuluanunclassified

Hubungan Kadar Serum Amh Dengan Jumlah Mutasi Pada Gen Promoter Amh (Anti-Mullerian Hormone) Pada Pasien Sopk (Sindrom Ovarium Polikistik)

et al. 2022

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Anti-Mullerian Hormone (AMH) adalah anggota dari kelompok Transforming Growth Factor-β yang berperan penting dalam regulasi folikulogenesis reproduksi wanita. Peningkatan kadar AMH 2-3 kali lipat ditemukan pada pasien SOPK (Sindrom Ovarium Polikistik) dibandingkan dengan wanita dengan ovulasi normal. Tujuan dari penelitian ini adalah untuk mengetahui hubungan kadar serum AMH dengan jumlah mutasi pada gen promoter AMH (Anti-Mullerian Hormone) pada pasien SOPK (Sindrom Ovarium Polikistik). Besar sampel adalah 114 pasien yang terdiri dari 60 pasien SOPK dan 54 pasien bukan SOPK sebagai kontrol. Kadar AMH didapatkan dari rekam medis pasien di Klinik Yasmin IVF RSCM Kencana Hospital, Jakarta. Analisis molekuler dan genotipe dilakukan dengan PCR dan sekuensing dilanjutkan dengan analisis bioinformatika. Terdapat 60 mutasi titik pada varian promotor gen AMH. Jenis mutasi varian tertinggi yang ditemukan adalah -674 G/A (100%), diikuti oleh -245 C/CT (88,2%), dan -444 A/G (17,9%) di seluruh sampel. Berdasarkan hasil uji Wilcoxon Signed Rank test, jumlah mutasi pada kelompok SOPK berpengaruh nyata terhadap AMH serum (p<0,05). Pada kelompok kontrol, jumlah mutasi tidak berpengaruh nyata terhadap kadar AMH (p>0,05). Jumlah mutasi pada promotor gen mempengaruhi kadar serum AMH pada PCOS.

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CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome

Xuan,

Ren,

et al. 2024

Molecular Reproduction Devel

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Inflammatory damage in ovarian granulosa cells (GCs) is a key mechanism in polycystic ovary syndrome (PCOS), cytoplasmic polyadenylation element binding protein‐1 (CPEB1) is important in inflammatory regulation, however, its role in PCOS is unclear. We aim to research the mechanism of CPEB1 in ovarian GCs in PCOS using dehydroepiandrosterone (DHEA)‐induced PCOS rat models and testosterone‐incubated GC models. The pathophysiology in PCOS rats was analyzed. Quantitative‐realtime‐PCR, TUNEL, immunohistochemistry, and Western blot were applied for quantification. Additionally, cell counting kit‐8, flow cytometry, immunofluorescence, Western blot, and Monodansylcadaverine staining were performed. We found that PCOS rat models exhibited a disrupted estrus cycle, elevated serum levels of testosterone, luteinizing hormone (LH), and follicle‐stimulating hormone (FSH), increased LH/FSH ratio, and heightened ovarian index. Furthermore, reduced corpus luteum and increased follicular cysts were observed in ovarian tissue. In ovarian tissue, autophagy and apoptosis were activated and CPEB1 was overexpressed. In vitro, CPEB1 overexpression inhibited cell viability and sirtuin‐1 (SIRT1), activated tumor necrosis factor‐α, and interleukin‐6 levels, as well as apoptosis and autophagy; however, CPEB1 knockdown had the opposite effect. In conclusion, overexpression of CPEB1 activated autophagy and apoptosis of ovarian GCs in PCOS.

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Polycystic ovary syndrome in adolescents with obesity

Cited by 4 publications

References 49 publications

Polycystic Ovarian Syndrome in Adolescents

Polycystic Ovarian Syndrome in Adolescents

Hubungan Kadar Serum Amh Dengan Jumlah Mutasi Pada Gen Promoter Amh (Anti-Mullerian Hormone) Pada Pasien Sopk (Sindrom Ovarium Polikistik)

CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome

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