The Protective Role of Silymarin to Ameliorate the Adverse Effects of Ochratoxin-A in Laying Hens on Productive Performance, Blood Biochemistry, Hematological and Antioxidants Status

Abstract

This study was planned to examine the effect of silymarin on diminishing adverse effects of ochratoxin-A (OTA) in laying hens. A total number of 300 Inshas, local layer hens of 28 weeks of age were randomly distributed into 4 groups with 5 replicates each (15 hens). The birds were fed on the following treatments, (Control): fed a hen diet without any supplementation; (SL): fed the control diet supplemented with SL (1000 mg/kg feed); (OTA-diet): was fed the control diet contaminated with 1 ppm of OTA/kg diet, and (OTA+SL): fed the OTA-diet plus SL (1ppm OTA+1000 mg SL/kg feed). Results showed that feeding OTA at 1 ppm reduced productive performance compared with those fed the control diet. In OTA treated groups the total erythrocytes count, leukocytes count, PCV and Hb were decreased when compared to the control and SL groups. Albumin, globulin and serum total proteins in OTA treated groups were significantly lower when compared to the control and SL groups. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly increased in OTA fed groups in comparison with the control and SL groups. Creatinine and uric acid were increased in OTA treated groups but were almost normal in the SL group. The results showed that OTA had a severe effect on liver and kidney, but SL treated group had normal liver and kidneys showing its hepatoprotective effects.

Effect of papaya (Carica papaya) seed as phytogenic feed additives on egg performance, egg quality and blood serum biochemical constituents of layer hens

“…The increase in serum total protein observed in the current study may be due to the increased availability of dietary protein, which was achieved by supplementing papaya seed PFAs at 15 g/kg. However, papaya seed does not contain a hepato‐protein inhibitor (Eid et al., 2021), which can lead to an accumulation of protein in the blood. Therefore, the absence of a hepato‐protein inhibitor in papaya seed may have also increased serum total protein levels.…”

Effects of Dietary Milk Thistle (Silybum marianum) Supplementation in Ducks Fed Mycotoxin-Contaminated Diets

“…Previous studies with poultry species have shown the positive effects of silymarin or the whole seed of the plant Silybum marianum against mycotoxins. Silymarin as a complex of active ingredients derived from milk thistle was found as hepato- and nephroprotective against ochratoxin A intoxication in broiler chickens and laying hens [ 16 , 20 ]. The protective effects of a silymarin product was observed on the liver of broilers fed a diet contaminated with aflatoxin and fumonisin [ 21 ].…”