Chia seed (Salvia hispanica L.) supplementation may contribute to raising the levels of vitamin B12: An option for the vegan diet

Demir, Enver Ahmet; Bilgic, Yasemin

doi:10.1590/1678-9865201932e180249

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…9 The levels of vitamin E have been found to vary between 0.5 and 8.2 mg/100 g. 112,113 A study in rats showed that a chia-rich diet significantly increased vitamin B12 levels, suggesting that chia may be a good additive for vegan diets where vitamin B12 levels may be low. 114…”

Section: Vitaminsmentioning

confidence: 99%

An update on the nutritional profiles of quinoa (Chenopodium quinoa Willd.), amaranth (Amaranthus spp.), and chia (Salvia hispanica L.), three key species with the potential to contribute to food security worldwide

et al. 2022

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One of the major challenges facing the world nowadays is to ensure enough access to healthy food for a growing population. Under this food scenario, it should be noted that increasing food production is as important as improving its nutritional quality. Thus, different agronomy research and innovation programs have pursued food security through the increase in the quantity and nutritional quality of plant‐based foods. One key aspect in this respect is to increase agrobiodiversity by expanding the cultivation of underutilized highly nutritious crops such as chia, quinoa, or amaranth. The outstanding nutritional value of these crops resides in the compositional characteristics of their seeds, which include the presence of significant levels (and a good balance) of proteins, essential amino acids, lipids, and other components such as phenols, minerals, fiber, or vitamins, all contributing to support nutritious diets that also has health benefits such as the prevention of cardiovascular diseases. All of them, chia, amaranth, and quinoa, are considered emerging crops outside their center of origin (which is mainly located in South America), and their cultivation has been expanded worldwide in the last decade. This review mainly highlights recent knowledge about the nutritional characteristics of these three Latin American crops, with the aim of providing an updated information regarding the compositional profiles of their seeds.

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Section: Vitaminsmentioning

confidence: 99%

An update on the nutritional profiles of quinoa (Chenopodium quinoa Willd.), amaranth (Amaranthus spp.), and chia (Salvia hispanica L.), three key species with the potential to contribute to food security worldwide

et al. 2022

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Chia seeds and coenzyme Q10 alleviate iron overload induced hepatorenal toxicity in mice via iron chelation and oxidative stress modulation

Sadek,

Marzouk,

Mohamed

et al. 2023

Sci Rep

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Iron overload (IOL) can cause hepatorenal damage due to iron-mediated oxidative and mitochondrial damage. Remarkably, combining a natural iron chelator with an antioxidant can exert greater efficacy than monotherapy. Thus, the present study aimed to evaluate the efficacy of Chia and CoQ10 to chelate excess iron and prevent hepatorenal oxidative damage in IOL mice. Male Swiss albino mice (n = 49) were randomly assigned to seven groups: control, dietary Chia, CoQ10, IOL, IOL + Chia, IOL + CoQ10, and IOL + Chia + CoQ10. Computational chemistry indicates that the phytic acid found in the Chia seeds is stable, reactive, and able to bind to up to three iron ions (both Fe2+ and Fe3+). IOL induced a significant (P < 0.05) increase in serum iron, ferritin, transferrin, TIBC, TSI, RBCs, Hb, MCV, MCH, WBCs, AST, ALT, creatinine, and MDA. IOL causes a significant (P < 0.05) decrease in UIBC, platelets, and antioxidant molecules (GSH, SOD, CAT, and GR). Also, IOL elicits mitochondrial membrane change depolarization, and DNA fragmentation and suppresses mitochondrial DNA copies. Furthermore, substantial changes in hepatic and renal tissue, including hepatocellular necrosis and apoptosis, glomerular degeneration, glomerular basement membrane thickening, and tubular degeneration, were observed in the IOL group. Dietary Chia and CoQ10 induced significant (P < 0.05) amelioration in all the mentioned parameters. They can mostly repair the abnormal architecture of hepatic and renal tissues induced by IOL, as signified by normal sinusoids, normal central veins, and neither glomerular damage nor degenerated tubules. In conclusion, the combined treatment with Chia + CoQ10 exerts more pronounced efficacy than monotherapy in hepatorenal protection via chelating excess iron and improved cellular antioxidant status and hepatorenal mitochondrial function in IOL mice.

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Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model

El makawy,

Abdel-Aziem,

Mohammed

et al. 2024

Bull Natl Res Cent

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Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy. So, the exploration of chemopreventive agents from efficient natural sources has been required. The chia and quinoa seeds have health-promoting activities that include cardio-protective, antidiabetic, and anticancer effects. Given the paramount importance of their oils and their potential bioactivities, this work aimed to assess the repressive effect of their oil nanocapsules against mammary tumors in rats. Rat models of chemically induced mammary tumors were gavaged with chia and quinoa nanocapsules for one month. The repressive effect of nanocapsules was studied by quantifying TNF-α, assessing the gene expression of proto-oncogenes (PIK3CA and MYC) using qRT-PCR, and analyzing the cell cycle in mammary tissue. Results The studies clarified that the inhibition of tumors in response to quinoa and chia nanocapsules was associated with a reduction in TNF-α levels, proliferation capability, and motivation for apoptosis. Furthermore, quinoa and chia nanocapsule management repressed the activation of the MYC and PIK3CA genes. As well as nanocapsules modulated the liver enzymes and kidney function alterations induced in mammary tumor animals. Meanwhile, both oils' nanocapsules do not have an impact on the liver and kidneys of healthy rats. Conclusions The findings indicate that quinoa and chia nanocapsules are safe and can reduce tumor growth, suggesting a potential natural therapeutic target for breast cancer treatment.

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Chia seed (Salvia hispanica L.) supplementation may contribute to raising the levels of vitamin B12: An option for the vegan diet

Cited by 4 publications

References 39 publications

An update on the nutritional profiles of quinoa (Chenopodium quinoa Willd.), amaranth (Amaranthus spp.), and chia (Salvia hispanica L.), three key species with the potential to contribute to food security worldwide

An update on the nutritional profiles of quinoa (Chenopodium quinoa Willd.), amaranth (Amaranthus spp.), and chia (Salvia hispanica L.), three key species with the potential to contribute to food security worldwide

Chia seeds and coenzyme Q10 alleviate iron overload induced hepatorenal toxicity in mice via iron chelation and oxidative stress modulation

Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model

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