2020
DOI: 10.1590/1678-9199-jvatitd-2019-0070
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Abstract: Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the those of the native toxin. However, from a clinical perspective, the intrathecal administration limits the use of anesthetic drugs in patients. Therefore, this study aimed to investigate the possible antinociceptive effect of intravenous recombinant Phα1β in rat models o… Show more

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Cited by 14 publications
(5 citation statements)
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“…As a calcium blocker, CTK 01512‐2 might be a good candidate for the preservation of some neuronal functions, such as muscle innervation. Another advantage of CTK 01512‐2 is the low toxicity seen by us and others (Rigo et al., 2020), which further supports preclinical analyses (Nicoletti et al., 2017). CTK 01512‐2 might therefore display a good safety profile.…”
Section: Discussionsupporting
confidence: 68%
“…As a calcium blocker, CTK 01512‐2 might be a good candidate for the preservation of some neuronal functions, such as muscle innervation. Another advantage of CTK 01512‐2 is the low toxicity seen by us and others (Rigo et al., 2020), which further supports preclinical analyses (Nicoletti et al., 2017). CTK 01512‐2 might therefore display a good safety profile.…”
Section: Discussionsupporting
confidence: 68%
“…administered CTK 01512-2 were also studied in the CCL-induced neuropathic pain and paclitaxel-induced acute and chronic pain in which the recombinant toxin exerted analgesic action. The analgesic effects were not accompanied by acute toxicity compared to morphine that induced significant changes in motor activity, HR, and blood pressure [134]. The analgesic effect was also elicited in male and female mice by CTK 01512-2 (0.06 and 0.6 mg/kg i.v) in a complex regional pain syndrome 1 model; the peptide attenuated mechanical and cold allodynia in the acute and chronic nociceptive state [135].…”
Section: Recombinant Ctk 01512-2 Shows Effects Similar To the Native Phαβ Toxinmentioning
confidence: 85%
“…Therefore, CTK 01512-2 i.v. did not induce motor alteration or alter cardiac parameters and biochemical markers in mice [ 145 ].…”
Section: N-type Vgccs Blockers Derived From Animal Venomsmentioning
confidence: 99%