2015
DOI: 10.1590/1678-775720130691
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Abstract: Phosphoric acid has been suggested as an irrigant due to its effectiveness in removing the smear layer. Objectives: The purpose of this study was to compare the antimicrobial and cytotoxic effects of a 37% phosphoric acid solution to other irrigants commonly used in endodontics.Material and Methods : The substances 37% phosphoric acid, 17% EDTA, 10% citric acid, 2% chlorhexidine (solution and gel), and 5.25% NaOCl were evaluated. The antimicrobial activity was tested against Candida albicans, Staphylococcus au… Show more

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Cited by 45 publications
(27 citation statements)
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“…Sodium hypochlorite is the most employed solution worldwide due to its extremely potent antimicrobial activity 22 - 25 and tissue dissolution 21 . However, it has its deficiencies, such as a lack of biocompatibility 5 , 9 .…”
Section: Discussionmentioning
confidence: 99%
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“…Sodium hypochlorite is the most employed solution worldwide due to its extremely potent antimicrobial activity 22 - 25 and tissue dissolution 21 . However, it has its deficiencies, such as a lack of biocompatibility 5 , 9 .…”
Section: Discussionmentioning
confidence: 99%
“…Ozone has been proposed as an alternative for Endodontic treatment due to its potent antimicrobial activity 2 , 6 , 7 , 10 , 12 - 18 , 20 as well as its low cytotoxicity within cells, which is the opposite from the highest concentration of sodium hypochlorite, being remarkably cytotoxic 22 .…”
Section: Discussionmentioning
confidence: 99%
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“…Using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTA), Prado et al 22 revealed that 10% citric acid showed higher cell viability compared with other tested irrigation solutions. Marins et al 23 assessed the capacity of some root canal irrigants to induce genetic damage and/or cellular death in marine fibroblasts in vitro.…”
Section: Toxicitymentioning
confidence: 99%
“…However, these two agents are synthetic materials that may negatively affect the vitality of healthy tissue around the teeth, thus affecting the prognosis of post-treatment recovery or even result in chronic post-operative pain [10][11][12][13]. Phosphoric acid (PA) has been also suggested as root canal irrigant for the purpose of removing the smear layer due to the ability of removing the latter [14] and its high antimicrobial effectiveness; however, its toxicity was higher when compared to other smear layer removal agents [15].…”
Section: Introductionmentioning
confidence: 99%