“…The importance of these diseases is given by the high prevalence, increasing, with values of 11.22% [8], 11.27% [9], 29.9% [10], and 33.7% in children aged 5 years [11], the associated complications and therapeutic difficulties encountered in both temporary and permanent dentition [12]. Acquired enamel defects have a multifactorial etiology related to genetic predisposition, perinatal hypoxia, prematurity, and some diseases of the infant and young child [12], and they are associated with the use of antibiotics in the first years of the child's life [13,14] or by pregnant women [15], especially amoxicillin. Other drugs also represent risk factors for DDE: cefaclor, paracetamol [16], penicillin [17], bronchodilators, corticosteroids [18], antiepileptics [19], celecoxib, erythromycin [20], and tetracycline [21].…”