BMI-1 expression increases in oral leukoplakias and correlates with cell proliferation

Klein, Isadora Peres; Meurer, Luíse; Danilevicz, Chris Krebs; Squarize, Cristiane H.; Martins, Manoela Domingues; Carrard, Vinícius Coelho

doi:10.1590/1678-7757-2019-0532

Cited by 7 publications

(3 citation statements)

References 32 publications

(8 reference statements)

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“…23 The cytoplasmic localization partially contradicts the consensus about the sole nuclear localization of BMI-1 in the neoplastic and the potentially malignant lesions showing high proliferative activity reported in previous studies. [24][25][26] The stromal fibroblasts in both groups of the present study showed strong intra-nuclear immunoreactivity to the BMI-1. This is in agreement with what was previously reported that BMI-1 has been shown to immortalize normal fibroblasts via reactivation of the human telomerase reverse transcriptase gene in these cells.…”

Section: Discussionsupporting

confidence: 54%

The expression of BMI-1 in ameloblastoma and dentigerous cyst

2022

Mansoura Journal of Dentistry

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Objective: To check for a possible relation between the expression of BMI-1 among two different odontogenic lesions; ameloblastoma and dentigerous cyst known for different biological behavior. Materials and Methods: The study was conducted on 14 formalin-fixed paraffin-embedded blocks (ameloblastoma (Am) group: seven blocks and dentigerous cyst (DC) group: seven blocks). These blocks were collected from archived files of the Department of Oral Pathology, Faculty of Dentistry, Mansoura University. Immunohistochemically (IHC), the BMI-1 polyclonal antibody expression in the retrieved sections was investigated. A computerized method was used to compare the IHC staining intensity between both groups. Results: The difference in the intensity of immunoreactivity to BMI-1 in two different studied groups was statistically non-significant to gender, age, and site (P > 0.05). The Am group showed significantly higher expression of BMI-1 than the DC group (P < 0.0001). Conclusions: BMI-1 is thought of as a useful marker probably delineating the variation in the biological behavior of Am and DC.

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Section: Discussionsupporting

confidence: 54%

The expression of BMI-1 in ameloblastoma and dentigerous cyst

2022

Mansoura Journal of Dentistry

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“…An increased number of proliferating cells can be observed in tissues with chronic inflammation as well as in tissues displaying hyperplasia in comparison with healthy tissues. Indices using the proliferation marker Ki-67 have been utilized in studies of LPL [ 18 , 19 ] but also OLP [ 20 , 21 ]. Because OLP and LPL present with different stages of chronic inflammation and altered epithelia, Ki-67 is a biomarker that can be used to compare cell proliferation rates in the two disorders.…”

Section: Introductionmentioning

confidence: 99%

Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia

Dafar

Siarov

Mostaghimi

et al. 2022

International Journal of Dentistry

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Although oral lichen planus (OLP) and oral leukoplakia (LPL) have different pathogenetic profiles, both may involve chronic inflammation. The aim of this observational study was to evaluate the inflammatory cell profiles of OLP and LPL. The inflammatory cell infiltrates in patients with OLP and LPL were analyzed for the presence of Langerhans cells (LCs; CD1a), T cells (CD3), and B cells (CD20), as well as for the proliferation marker Ki-67. Biopsied specimens from patients with OLP (N = 14) and LPL without dysplasia (N = 13) were immunohistochemically stained with antibodies directed against CD1a, CD3, CD20, and Ki-67, followed by quantitative analyses. A significant increase in the number of CD3+ cells and CD20+ cells was found in the submucosa of OLP, as compared to LPL ( p < 0.01 ). Likewise, the number of CD3+ cells was significantly higher in the epithelium of OLP than of LPL ( p < 0.05 ). No differences were found in the expression of Ki-67 and the number of CD1a+ cells between the two groups. Although an immune response is elicited in both conditions, there are differences at the cellular level between OLP and LPL. A more robust immune activation involving T cells and B cells is seen in OLP. The role of B cells in OLP needs to be further elucidated. Although the number of B cells in LPL is low, their role in the inflammatory response cannot be ruled out.

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“…Cell proliferation proteins (Ki-67, CK-14, and Survivin) have also been extensively investigated in OL patients compared to oral cancer samples. It has been demonstrated that Ki-67 expression gradually increased through normal, non-dysplastic and dysplastic OL, and OSCC (36,54,55). The expression of Survivin and CK-14 also seemed statistically different among OSCC, OL, and normal mucosa, usually overexpressed in OSCC (p < 0.01) (28, 41, 42, 56-58).…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis reveals the protein profile associated with malignant transformation of oral leukoplakia

Normando

Santos²,

Sá³

et al. 2023

Front. Oral. Health

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The search for biomarkers associated with oral leukoplakia malignant transformation is critical for early diagnosis and improved prognosis of oral cancer patients. This systematic review and meta-analysis aimed to assess protein-based markers potentially associated with malignant transformation of oral leukoplakia. Five database and the grey literature were searched. In total, 142 studies were included for qualitative synthesis, where 173 proteins were investigated due to their potential role in malignant progression from oral leukoplakia (OL) to oral squamous cell carcinoma (OSCC). The abundance of these proteins was analyzed in fixed tissues and/or biofluid samples, mainly by immunohistochemistry and ELISA, and 12 were shared by both samples. Enrichment analysis revealed that the differential abundant proteins are mostly involved with regulation of cell death, regulation of cell proliferation, and regulation of apoptotic process. Also, these proteins are mainly expressed in the extracellular region (55.5%), cell surface (24.8%), and vesicles (49.1%). The meta-analysis revealed that the proteins related to tumor progression, PD-L1, Mdm2, and Mucin-4 were significantly associated with greater abundance in OSCC patients, with an Odds Ratio (OR) of 0.12 (95% CI: 0.04–0.40), 0.44 (95% CI: 0.24–0.81), and 0.18 (95% CI: 0.04–0.86), respectively, with a moderate certainty of evidence. The results indicate a set of proteins that have been investigated across OSCC initiation and progression, and whose transcriptional expression is associated with clinical characteristics relevant to the prognosis and aggressiveness. Further verification and validation of this biomarkers set are strongly recommended for future clinical application.

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BMI-1 expression increases in oral leukoplakias and correlates with cell proliferation

Cited by 7 publications

References 32 publications

The expression of BMI-1 in ameloblastoma and dentigerous cyst

The expression of BMI-1 in ameloblastoma and dentigerous cyst

Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia

A meta-analysis reveals the protein profile associated with malignant transformation of oral leukoplakia

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