Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages

Rda, Figueiredo; Ac, Ortega; Gonzalez-Maldonado, Laura; Castro, Rd; Mj, Avila-Campos; Rossa, Carlos; Sg, Aquino

doi:10.1590/1678-7757-2019-0519

Cited by 13 publications

(7 citation statements)

References 36 publications

(16 reference statements)

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“…Perillaldehyde efficiently inhibits airborne microbes using an air-washer, contributing to improve environmental health (Sato et al 2006), and showed antibacterial activity against respiratory tract pathogens, such as Haemophilus influenza, Streptococcus pneumoniae, S. pyogenes [minimum inhibitory dose (MID) of 12.5 mg.L -1 air, respectively], and Staphylococcus aureus (MID=50 mg.L -1 air) (Inouye et al 2001), and against foodborne bacteria Escherichia coli, E. coli 0157:H7, Salmonella typhimurium (MIC=500 µg.mL -1 , respectively), and Vibrio vulnificus (MIC=250 µg.mL -1 ) (Kim et al 1995). Perillyl alcohol proved to be a potent natural chemosensitizing agent against fungal infections, acting by multiple mechanisms of action (Ansari 2016), and has a strong antibacterial effect against the periodontal pathogens Fusobacterium nucleatum and Porphyromonas gingivalis (Figueiredo et al 2020), while (+)-limonene has been described as a bactericidal agent to be used in food preservation, effecting Gramnegative bacteria (Espina 2013). The presence of compounds with proven antimicrobial activity reinforces the potential pharmacological use of essential oils, as well as preservative and flavoring agents.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial potential of Pectis substriata essential oil (Asteraceae) against drug-resistant Staphylococcus strains

Jesus

Micheletti

Takahashi

et al. 2020

An. Acad. Bras. Ciênc.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial potential of Pectis substriata essential oil (Asteraceae) against drug-resistant Staphylococcus strains

Jesus

Micheletti

Takahashi

et al. 2020

An. Acad. Bras. Ciênc.

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“…PA has efficiently inhibited biofilm formation and eradicated preformed biofilm of C. glabrata , where it has exhibited cidal activity. Similar growth inhibitory activity of PA was evaluated against Fusobacterium nucleatum, Porphyromonas gingivalis , and C. albicans . , One of the most unique features of phytochemicals is their synergistic effects with the known therapeutic formulations. Various terpenes have been reported to reduce the MIC value of azoles and thus exhibited synergy against fungal cells. , PA has also exhibited synergy with azole drug(s) fluconazole and miconazole against CG and with miconazole against fluconazole resistant clinical isolate CCG3 (Table ).…”

Section: Discussionmentioning

confidence: 99%

“…Similar growth inhibitory activity of PA was evaluated against Fusobacterium nucleatum, Porphyromonas gingivalis , and C. albicans . 18 , 24 One of the most unique features of phytochemicals is their synergistic effects with the known therapeutic formulations. Various terpenes have been reported to reduce the MIC value of azoles and thus exhibited synergy against fungal cells.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the Eradication Mechanism of Perillyl Alcohol against Candida glabrata Biofilms: Insights into the Synergistic Effect with Azole Drugs

Gupta

Poluri

2021

ACS Bio Med Chem Au

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Increased incidences of fungal infections and associated mortality have accelerated the need for effective and alternative therapeutics. Perillyl alcohol (PA) is a terpene produced by the hydroxylation of limonene via the mevalonate pathway. In pursuit of an alternative antifungal agent, we studied the effect of PA on the biofilm community of Candida glabrata and on different cellular pathways to decipher its mode of action. PA efficiently inhibited growth and eradicated biofilms by reducing carbohydrate and eDNA content in the extracellular matrix. PA reduced the activity of hydrolytic enzymes in the ECM of C. glabrata biofilm. The chemical profiling study has given insights into the overall mode of action of PA in C. glabrata and the marked involvement of the cell wall and membrane, ergosterol biosynthesis, oxidative stress, and DNA replication. The spectroscopic and RT-PCR studies suggested a strong interaction of PA with chitin, β-glucan, ergosterol, and efflux pump, thus indicating increased membrane fluidity in C. glabrata. Furthermore, the microscopic and flow cytometry analysis emphasized that PA facilitated the change in mitochondrial activity, increased Ca 2+ influx via overexpression of voltage-gated Ca 2+ channels, and enhanced cytochrome C release from mitochondria. In addition, PA interferes with DNA replication and thus hinders the cell cycle progression at the S-phase. All these studies together established that PA mitigates the C. glabrata biofilms by targeting multiple cellular pathways. Interestingly, PA also potentiated the efficacy of azole drugs, particularly miconazole, against C. glabrata and its clinical isolates. Conclusively, the study demonstrated the use of PA as an effective antifungal agent alone or in combination with FDA-approved conventional drugs for fungal biofilm eradication.

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“…PMX205 (69)]. In addition, they still have some other effects, such as promoting bone regeneration [Dioscin (71)], antibacterial (Perillyl alcohol [POH) (72)] and so on. The effects of other drugs targeting macrophages with positive effects either on cell behavior or molecular expression are shown in Table 1.…”

Section: Drugs Targeting Macrophagesmentioning

confidence: 99%

Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives

Yang

Pang

et al. 2021

Front. Immunol.

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Periodontitis is one of the most common dental diseases. Compared with healthy periodontal tissues, the immune microenvironment plays the key role in periodontitis by allowing the invasion of pathogens. It is possible that modulating the immune microenvironment can supplement traditional treatments and may even promote periodontal regeneration by using stem cells, bacteria, etc. New anti-inflammatory therapies can enhance the generation of a viable local immune microenvironment and promote cell homing and tissue formation, thereby achieving higher levels of immune regulation and tissue repair. We screened recent studies to summarize the advances of the immunomodulatory treatments for periodontitis in the aspects of drug therapy, microbial therapy, stem cell therapy, gene therapy and other therapies. In addition, we included the changes of immune cells and cytokines in the immune microenvironment of periodontitis in the section of drug therapy so as to make it clearer how the treatments took effects accordingly. In the future, more research needs to be done to improve immunotherapy methods and understand the risks and long-term efficacy of these methods in periodontitis.

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Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages

Cited by 13 publications

References 36 publications

Antimicrobial potential of Pectis substriata essential oil (Asteraceae) against drug-resistant Staphylococcus strains

Antimicrobial potential of Pectis substriata essential oil (Asteraceae) against drug-resistant Staphylococcus strains

Elucidating the Eradication Mechanism of Perillyl Alcohol against Candida glabrata Biofilms: Insights into the Synergistic Effect with Azole Drugs

Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives

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