Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis

Abstract

Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis The evidence is inconclusive regarding the effect of periodontal treatment on glycemic control and systemic inflammation in patients with type 2 diabetes (T2D) and periodontitis Objective: To evaluate the effect of scaling and root planing (SRP) on the metabolic control and systemic inflammation of patients with type 2 diabetes (T2D). Methodology: A literature search was conducted using the MEDLINE database via PubMed and the Cochrane Central Register of Controlled Trials, from their oldest records up to July 2018. Only randomized clinical trials (RCT) were considered eligible for evaluating the effect of periodontal treatment on markers of metabolic control [glycated hemoglobin (HbA1C)] and systemic inflammation [C-reactive protein (CRP)] in patients with T2D. The quality of the studies was evaluated using the Cochrane Collaboration risk assessment tool. Meta-analyses were performed for HbA1c and CRP using random effects models. The size of the overall intervention effect was estimated by calculating the weighted average of the differences in means (DM) between the groups in each study. Heterogeneity was assessed using the Q-statistic method (x 2 and I²). The level of significance was established at p<0.05. Results: Nine RCT were included. SRP was effective in reducing HbA1c [DM=0.56 (0.36-0.75); p<0.01] and CRP [DM=1.89 (1.70-2.08); p<0.01]. No heterogeneity was detected (I 2 =0%, p>0.05). Conclusions: SRP has an impact on metabolic control and reduction of systemic inflammation of patients with T2D.

Periodontal Disease in Diabetes Mellitus: A Case–Control Study in Smokers and Non-Smokers

“…DM has several known complications, including retinopathy, nephropathy, neuropathy, macrovascular abnormalities, prolonged wound healing and PD [23]. The increasing number of recent studies that have focused on examining the relationship between DM and PD testified to a definite surge in scientific interest [24][25][26]. Given that certain cytokines and other inflammatory mediators are involved in both diseases, DM and PD appear to have a mutually detrimental effect on each other.…”

“…Our research group has been investigating the relationship between various systemic diseases for a decade, including systemic conditions such as psoriasis and rheumatoid arthritis, and we are especially interested in the additional effect of smoking [25]. In 2014, we first proposed that smoking may act as a permissive factor of PD in patients with psoriasis [11], and we subsequently demonstrated something similar in rheumatoid arthritis [53].…”

Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature Review

“…Diabetes is a multifactorial metabolic disease characterized by chronic hyperglycemia and disturbances in the metabolism of carbohydrates, lipids, and proteins. It is caused by a deficiency in insulin secretion (type I), the action of insulin (type II), or both [ 30 , 37 , 38 ].…”

Biosensor and Lab-on-a-chip Biomarker-identifying Technologies for Oral and Periodontal Diseases

“…Since periodontitis is a chronic inflammatory disease associated with microbial dysbiosis and host-driven tissue destruction (Atieh et al, 2014;Artese et al, 2015;Garde et al, 2019;Baeza et al, 2020) (Darre et al, 2008Engebretson and Kocher, 2013;Faggion Jr. et al, 2016;Ziukaite et al, 2018;Jain et al, 2019) Cardiovascular disease (Mustapha et al, 2007;Paraskevas et al, 2008;Freitas et al, 2012;Teeuw et al, 2014;Munz et al, 2018;Roca-Millan et al, 2018;Joshi et al, 2019;Munoz Aguilera et al, 2020) ( Bahekar et al, 2007;Blaizot et al, 2009;Almeida et al, 2018) Rheumatoid arthritis (Han and Reynolds, 2012;Kaur et al, 2014;Bender et al, 2017;Calderaro et al, 2017;Eskandari-Nasab et al, 2017;Hussain et al, 2020) ( Tang et al, 2017;Qiao et al, 2020) Obesity (Akram et al, 2016) (Papageorgiou et al, 2015) Irritable bowel disease * (Eskandari-Nasab et al, 2017;Papageorgiou et al, 2017;Lauritano et al, 2019;She et al, 2020) Osteoporosis (Kornman, 2008;Darveau, 2010), it is recognized that a single oral pathogen would not be sufficient to induce the most common forms of periodontitis. However, historically there were several studies focused on small subgroups of patients with rapidly progressing bone destruction occurring around certain teeth (molars and incisors), called localized aggressive periodontitis, whi...…”