Evaluation of tumor markers carcinoembryonic antigen, cytokeratin 19 fragment and cancer-associated antigen 72-4 in neoplastic and non-neoplastic canine effusions differentiation

Teixeira, Luciele Varaschini; Guerra, Tatiana Amaral; Conrado, Francisco de Oliveira; Terra, Sílvia Resende; Gerardi, Daniel Guimarães; González, Félix Hilario Díaz

doi:10.1590/1678-6820

Cited by 3 publications

(3 citation statements)

References 20 publications

(14 reference statements)

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“…La trombocitopenia encontrada en el hemograma podría ser causada por el proceso neoplásico (13), debido probablemente a defectos en la producción por parte de la medula ósea ( 14) junto al exudado no séptico peritoneal (15), quienes reportan la predominancia de neutrófilos no degenerados y niveles elevados de proteína. morfológicamente como derrames abdominales son asociados a procesos patológicos de las superficies parietales y viscerales de la cavidad como son los tumores malignos que pueden conducir a ascitis, ya que la membrana serosa contiene la neoplasia (16,17,18) con la consiguiente producción de exudado.…”

Section: Discussionunclassified

Leiomiosarcoma peritoneal en un canino: reporte de caso

Ochoa-Amaya¹,

Zambrano²,

Roque-Rodriguez³

et al. 2019

Rev MVZ Córdoba

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The purpose of this study is to present a peritoneal leiomyosarcoma in a canine and its histopathological and immunohistochemical findings. The patient, a 5-year old female Chow-Chow, was brought to Los Llanos University veterinary clinic due to loss of appetite, prostration and poor corporal condition. Physical examination showed pale mucous membranes, increased abdominal silhouette with a serosanguineous fluid content. Palpation at the cranial epigastrium evidenced a painless mass of hard consistency, irregular surface and caudally displaceable. Serum biochemical abnormalities included increased plasma total protein, globulin and creatinine. Thus, an exploratory laparotomy was performed, identifying a mass in the mesentery attached to a portion of the small intestine. In its report it was stated the following macroscopic findings: a firm mass of 18 cm long and 13 cm wide, with irregular surface, great vascularization. Tissue samples were fixed in 10% buffered formalin for histopathological and immunohistochemical analysis. Samples were processed by routine methods for microscopy and stained with hematoxylin-eosin (HE), Masson trichrome, anti-cytokeratin CK5, anti-smooth muscle actin, vimentin and KIT(CD117) antibodies. In conclusion, the tumor was classified by histopathology as of mesenchymal origin and internal diffuse cytoplasmic immunopositivity of neoplastic cells for smooth muscle actin, vimentin and was negative for KIT led to diagnose of leiomyosarcoma.

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Section: Discussionunclassified

Leiomiosarcoma peritoneal en un canino: reporte de caso

Ochoa-Amaya¹,

Zambrano²,

Roque-Rodriguez³

et al. 2019

Rev MVZ Córdoba

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“…Essas substâncias funcionam como indicadores da presença de alterações celulares, e podem ser produzidas diretamente pelo tumor ou pelo organismo, em resposta à presença de neoplasias ou outras doenças não malignas. Em sua maioria os marcadores tumorais são proteínas, antígenos de superfície celular, proteínas citoplasmáticas, enzimas ou hormônios [2]. Esses marcadores podem ser úteis no manejo clínico dos pacientes com câncer, auxiliando nos processos de diagnóstico, estadiamento, avaliação de resposta terapêutica, detecção de recidivas e prognóstico, além de auxiliar no desenvolvimento de novas modalidades de tratamento.…”

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Análise de marcadores tumorais no município de Serrinha-Ba/Brasil

Silva

Rodrigues

Ribas

et al. 2021

Rev. Bras. Ciênc. Biomed.

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O câncer é uma das causas de maior mortalidade e morbidade em todo o mundo, sendo caracterizado como um dos principais problemas de saúde pública. Por isso existe uma necessidade premente em identificar marcadores tumorais específicos para auxiliar no diagnóstico e evitar a recidiva do câncer. Estes marcadores tumorais são componentes celulares, estruturais e bioquímicos que conseguem definir alterações celulares e moleculares associadas à conversão de malignidade. Idealmente, um marcador tumoral deveria elevar-se no sangue somente quando ocorresse a presença de tumores e não quando o individuo apresentasse alguma outra doença. O valor clínico para qualquer marcador tumoral sempre dependerá de sua sensibilidade, especificidade, bem como de sua aplicação clínica. Marcadores tumorais conhecidos atualmente não são suficientemente sensíveis para serem utilizados na triagem populacional ou para diagnostico primário de câncer porque nem todos os tumores são produtores eficientes de marcadores. O objetivo desse trabalho é analisar as tendências das alterações nos valores séricos dos marcadores tumorais biológicos (AFP, AC 19.9, CEA) em 200 indivíduos usuários do Sistema Único de Saúde (SUS), que frequentam a unidade laboratorial de saúde pública (Laboratório Municipal de Referência Regional/Lacen Serrinha) do município de Serrinha-BA com idade entre 30 e 70 anos e que residam na mesma cidade. O marcador tumoral AFP e o CA19.9, foram os que apresentaram maior percentual de elevação na população em estudo, estando em conformidade com literatura consultada.

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“…CEA is the serum biomarker, that produced from neoplasm of epithelial origin. Elevation of this protein was mostly related to malignant histiocytosis, fibrosarcoma, colorectal and gastric cancer in both human and veterinary medicine (Hanglund et al, 1991;Teixeira et al, 2014). In addition, low diagnostic value of CEA, 52% sensitivity and 55% specificity has been reported in cholangiocarcinoma (Lumachi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Clinical diagnosis, ultrastructural study and antigenic characterization of platynosomum fastosum in cats

Soe¹

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Platynosomum fastosum is a cat liver fluke causing hepatobiliary diseases in cats. To evaluate the criterior to support the suspicion index for early disease detection during subclinical infection, the biochemical parameters composed of liver, pancreatic enzymes, tumor markers were evaluated in 14 P. fastosum naturally-infected cats. As a result, alanine transaminase (ALT) and gamma glutamyl transferase (GGT) were found elevated in 57.8% (8/14) of infected cats. For the diagnostic imaging, bile sediments were present in 85.7% (12/14) of infected cats in their gallbladders. Since the number of bile-derived P. fastosum eggs were significantly higher than that from fecal samples (p=0.001), percutaneous ultrasound-guided cholecystocentesis seemed to be promising to be implemented as a tool for final diagnosis. To establish the fundamental data on ultrastructural characteristics of P. fastosum adult and egg for further drug testing as no effective drug available, scanning electron microscope was used to reveal the tegumental surface in which it was covered with densely packed villous-like projections and papillae. Using transmission electron microscope, at least one type of tegumental cell was found producing 2 types of tegumental granules inside P. fastosum adult tegument. To develop serodiagnostic assay, antigenic components of P. fastosum were characterized and 3 immunogenic proteins (70kDa, 53kDa and 13kDa) were identified and the sequences were characterized.

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Evaluation of tumor markers carcinoembryonic antigen, cytokeratin 19 fragment and cancer-associated antigen 72-4 in neoplastic and non-neoplastic canine effusions differentiation

Cited by 3 publications

References 20 publications

Leiomiosarcoma peritoneal en un canino: reporte de caso

Leiomiosarcoma peritoneal en un canino: reporte de caso

Análise de marcadores tumorais no município de Serrinha-Ba/Brasil

Clinical diagnosis, ultrastructural study and antigenic characterization of platynosomum fastosum in cats

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