Avaliação do efeito trombogênico da perfusão regional intravenosa com gentamicina em equinos

Rafael, Leandro Américo; Rodrigues, Celso António; Evangelista, Felipe Carvalho; Ramires, C.; Rodrigues, Marcos Sales; Pizzigatti, Dietrich; Perri, Sílvia Helena Venturoli; Hussni, Carlos Alberto

doi:10.1590/1678-6708

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…In the occurrence of failures in controlling the hemostatic activity of blood, there is inadequate formation of the aggregation of figured elements of blood (thrombi) within the vascular bed, enabling total or partial obstruction of the lumen and, in sequence, a limitation in the regional blood drainage or perfusion (Bonagura et al 2010, Borghesan 2010, Rafael 2012.…”

Section: Introductionmentioning

confidence: 99%

Thromboelastometric evaluation of horses submitted to experimental thrombosis and jugular thrombectomy

et al. 2016

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Jugular thrombosis in horses occurs commonly in iatrogenic situations, secondary to endotoxemic clinical condition and disseminated vascular coagulation, potentially leading to death. Thus, hemostatic evaluation becomes necessary and extremely important for monitoring the risks of systemic hypercoagulability and for the efficiency of allopathic and surgical treatment. This paper describes the hemostatic behavior in experimental jugular thrombosis of ten healthy equines, subsequently submitted to two thrombectomy techniques and receiving heparin sodium as anti-rethrombosis therapy. These animals were evaluated for 20 days by thromboelastometry (TEM), platelet count, hematocrit and fibrinogen, at four moments: pre-induction to phlebitis (D0-MPF); three days after thrombophlebitis induction (D3-MFM); 6 days after, -moment of thrombophlebitis -(D9-MT); and 54 (D16) and 126 (D19) hours after thrombectomies (PTM). Thrombectomy was performed via a Vollmar Ring (group 1, n=5) and Fogarty catheter (group 2, n=5). All the animals received heparin (150 UI/kg, SC) every 12 hours, for ten days after the respective thrombectomies. Through the blood samples were evaluated TEM, activated partial thromboplastin time (aPTT) and prothrombin time (PT), dosing of fibrinogen, hematocrit and platelet count at the abovementioned moments. For comparison between groups and moments the t test was applied at 5% significance level. No significant difference was verified between treatment groups at any of the moments. There were reductions in clotting time (CT) and clot formation time (CFT), with increase in maximum lysis (ML) until the moment D9-MT. Evaluation through INTEM ® reagent presented prolongations of CT and CFT with reduction of α angle and ML starting from D16 and D19. Similarly, aPTT presented significant differences between moments pre-(D0, 3 and 9) and post-(D16 and 19) anticoagulant and surgical treatment. The platelet numbers were diminished at moments D16 and D19. In evaluation with EXTEM ® reagent, prolongation of CT and CFT occurred only between the moments D0 vs. D3 and vs. D9. O PT did not present significant differences. The results obtained demonstrate that experimental jugular thrombophlebitis leads to local clinical alterations, with impairment of tissue and of the extrinsic coagulation pathway (EXTEM ® ), but without evidence of systemic hypercoagulability status, since there was no increase of the alpha angle or maximum clot firmness (MCF). Furthermore, TEM was shown useful and more sensitive than conventional coagulation tests (PT, aPTT and fibrinogen) for the monitoring of anticoagulant therapy, as demonstrated in other works. Houve diminuição do número de plaquetas nos momentos D16 e D19. Na avaliação com reagente extem ocorreu apenas o prolongamento do CT e CFT entre os momentos D0 e o D3 e D9. O TP não apresentou diferenças significativas. Os resultados obtidos demonstram que a tromboflebite jugular experimental leva a alterações clínicas locais, com comprometimento tecidual e da via extrínseca da coagulação ...

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Section: Introductionmentioning

confidence: 99%

Thromboelastometric evaluation of horses submitted to experimental thrombosis and jugular thrombectomy

et al. 2016

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Perfusão regional do membro com antimicrobianos em equinos

Schade

Curti

Gonçalves

et al. 2019

Rev. Ciênc. Agrovet.

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As infecções ortopédicas são condições comumente observadas em equinos, afetando frequentemente estruturas nobres como ossos e tecido sinovial. Afecções de origem séptica são de extrema importância na espécie equina, pois podem resultar em claudicação permanente provocada por danos articulares irreversíveis. Desta forma, tratamentos que resultam em concentrações elevadas de antimicrobianos nas áreas infectadas atuam de maneira mais eficaz na eliminação da população bacteriana nestes tecidos. Neste sentido, a perfusão regional do membro tem se mostrado uma excelente alternativa. A presente revisão aborda os principais aspectos relacionados às técnicas de perfusão regional do membro com antimicrobianos em equinos. Serão descritas as técnicas intravenosa e intraóssea, as quais envolvem a administração de antimicrobianos, em uma região selecionada do membro, isolada previamente da circulação sistêmica por meio da aplicação de um torniquete. A perfusão regional tem sido descrita com sucesso no tratamento de condições sépticas da região distal do membro de equinos, visto que altas concentrações de antimicrobianos são alcançadas nos locais afetados. Além disso, é de fácil realização e apresenta baixo risco de efeitos adversos sistêmicos, bem como custo reduzido.

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Avaliação do efeito trombogênico da perfusão regional intravenosa com gentamicina em equinos

Cited by 2 publications

References 19 publications

Thromboelastometric evaluation of horses submitted to experimental thrombosis and jugular thrombectomy

Thromboelastometric evaluation of horses submitted to experimental thrombosis and jugular thrombectomy

Perfusão regional do membro com antimicrobianos em equinos

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