Progesterone and estrogen receptor expression by canine cutaneous soft tissue sarcomas

Loures, Fabrícia Hallack; Conceição, Lissandro Gonçalves; Amorim, Renée Laufer; Nóbrega, Juliano; Neto, Rafael Torres; Costa, Eduardo Paulino da; Silva, Fabyano Fonseca e

doi:10.1590/1678-5150-pvb-6103

Cited by 2 publications

(1 citation statement)

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“…The lack of a relationship between PR expression and the studied variables (clinical, histopathological and IHC) differs from reports on canine cutaneous sarcomas, which showed a correlation between PR expression with tumour histologic grade and Ki‐67 with a possible impact of progesterone in the development of these tumours 39 . This suggests differences in the immunohistochemical profile of hormone receptors between dogs and cats.…”

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confidence: 69%

Hormone receptor expression, clinical and histopathological analysis in feline injection site sarcomas

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Conceição

Loures

et al. 2020

Vet Comparative Oncology

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Feline injection site sarcomas (FISS) are aggressive, with high recurrence and rarely metastasising. The objective of this study was to evaluate, by immunohistochemistry, the expression of oestrogen (ER) and progesterone (PR) receptors in FISS and correlate them with clinical and histopathological aspects. This was a retrospective study with 51 cases of FISS. Immunohistochemistry was performed to detect vimentin, ER, PR and Ki67 expression. Clinical, histopathological and immunohistochemical characteristics were predictor variables and the expression of ER and PR were the dependent ones. Twenty‐eight (55%) of the 51 FISS cases were female and 23 (45%) male with 10.7 ± 4.2 years and median tumour size of 3 cm (2.0‐5.4). The trunk was the most affected site, with 38 cases (84%). Histological grade III was observed in 57% of the cases, considering differentiation score, necrosis and mitotic index. ER expression, positive in 64% of cases, was associated with the mitotic index (P = .05) and degree of pleomorphism (P = .04). PR was not associated with the variables and 63% of cases were negative for this receptor. Thus, ER expression can affect tumour growth. The knowledge on the FISS hormonal expression is important to clarify the pathophysiological mechanisms. Further studies are needed to predict the value of ER expression in the prognosis of FISS.

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Section: Discussioncontrasting

confidence: 69%

Hormone receptor expression, clinical and histopathological analysis in feline injection site sarcomas

Zanuncio

Conceição

Loures

et al. 2020

Vet Comparative Oncology

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Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas

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Franzoni

Anjos³

et al. 2023

Veterinary Sciences

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Soft tissue sarcomas (STSs) are a heterogeneous group of malignant mesenchymal tumors with similar histological features and biological behaviors. They are characterized by a low to moderate local recurrence rate and low metastasis, affecting approximately 20% of patients. Although this tumor set is vital in veterinary medicine, no previous unified staging system or mitotic count has been associated with patient prognosis. Therefore, this study proposed a new clinicopathological staging method and evaluated a cut-off value for mitosis related to the survival of dogs affected by STS. This study included 105 dogs affected by STS, treated only with surgery, and a complete follow-up evaluation. The new clinicopathological staging system evaluated tumor size (T), nodal involvement (N), distant metastasis (M), and histological grading criteria (G) to categorize the tumor stage into four groups (stages I, II, III, and IV). The proposed tumor staging system was able to differentiate patients’ prognoses, with dogs with stage IV disease experiencing the lowest survival time and dogs with stage I disease having the highest survival time (p < 0.001). Moreover, we assessed the median mitosis (based on mitotic count) and its association with overall survival. Our study’s median mitosis was 5, and patients with ≤5 mitoses had a higher survival time (p = 0.006). Overall, the proposed staging system and mitotic count seemed promising in the prediction of patient prognosis.

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Progesterone and estrogen receptor expression by canine cutaneous soft tissue sarcomas

Cited by 2 publications

References 26 publications

Hormone receptor expression, clinical and histopathological analysis in feline injection site sarcomas

Hormone receptor expression, clinical and histopathological analysis in feline injection site sarcomas

Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas

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