Esteatose hepática altera acúmulo celular em tilápias do Nilo durante aerocistite infecciosa

Moraes, Alessandra Cristina de; Prado, E. J. R.; Foz, Elizabeth P.; Barbuio, Roberto; Faria, Vanessa Pavesi de; Belo, Marco Antônio de Andrade

doi:10.1590/1678-5150-pvb-5533

Cited by 11 publications

(5 citation statements)

References 36 publications

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“…The increase in the metabolic degradation of the drug in hepatocytes can result in the production of free radicals that favor the increase of lipid peroxidation and consequently changes in the permeability of the hepatocyte plasma membrane, which can result in extravasation of this enzyme, as well as in the most severe cases cause cytotoxicity (Moraes et al, 2018;Oliveira et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

SAFETY OF ORAL DOXYCYCLINE TREATMENT IN NILE TILAPIA, Oreochromis niloticus

OLIVEIRA¹,

COSTA²,

CONDE³

et al. 2022

Ars Vet

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This study aimed to evaluate the clinical safety of doxycycline treatment (Sandoz Pharmacetical Industry from Brazil Ltd.), administered orally incorporated into the feed of Nile tilapia, Oreochromis niloticus. For this purpose, 75 Nile tilapia (± 300g) from the same spawning were randomly distributed in 15 tanks (n=5), containing 100 L of water each, supplied with running water free from chlorine, to establish the following treatments: T0 (Control -not treated with doxycycline); T1, T2, T3 and T4 (treated with 10, 20, 40 and 80mg of doxycycline/kg of body weight, respectively), in which 5 animals per treatment were sampled in 3 periods: 2, 4 and 8 days post-treatment (DPT). Blood samples were collected for hemogram determination and serum biochemical evaluation, as well as spleen, liver and kidneys (cranial and caudal) for somatic and histopathological evaluation. The results showed no significant difference among treatments in the serum values of creatinine, total protein, cholesterol, triglycerides, globulin, glycemia and alkaline phosphatase enzyme activity. However, serum levels of AST (aspartate aminotransferase) were significantly higher (P<0.05) in animals treated with 80 mg of doxycycline in the longest period of treatment (8 days). In the hematological evaluation of tilapia treated with doxycycline, no significant changes (P>0.05) were observed in erythrocyte counts, hematocrit, MCV, HCM and CHCM values. Doxycycline-treated tilapia did not present significant difference in the somatic analysis of spleen, liver and kidney when compared to control group. Therefore, the results demonstrated the clinical safety of oral treatment with doxycycline at doses of 10, 20, 40 and 80 mg/kg of b.w., although transient changes in liver functionality were observed after eight days of treatment with the dose of 80mg/kg.

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Section: Discussionmentioning

confidence: 99%

SAFETY OF ORAL DOXYCYCLINE TREATMENT IN NILE TILAPIA, Oreochromis niloticus

OLIVEIRA¹,

COSTA²,

CONDE³

et al. 2022

Ars Vet

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“…The antioxidant effect of astaxanthin resulted in a decrease in the number of thrombocytes and leukocytes in tilapias, marked by a decrease in the number of lymphocytes and neutrophils. These results suggest the hypothesis that fish supplemented with astaxanthin had a better leukocyte response, since modulation in circulating levels of white blood cells usually occurs during inflammatory defense responses (Moraes et al, 2018;Prado et al 2018). Belo et al (2014) observed a similar effect with improved leukocyte response in pacus supplemented with vitamin E during foreign body inflammatory reaction.…”

Section: Discussionmentioning

confidence: 73%

EFFECT OF DIETARY SUPPLEMENTATION WITH ASTAXANTHIN ON THE HEMATOLOGICAL AND BIOCHEMICAL RESPONSE OF NILE TILAPIA (Oreochromis niloticus)

Aracati

Oliveira²,

Rodrigues³

et al. 2021

Ars Vet

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This study aimed to evaluate the effect of astaxanthin on the hematological, biochemical and somatic response of Nile tilapia (Oreochromis niloticus) orally administered in the feed for a period of 60 days. For the study, 105 tilapia (n=35) from the same spawn were used, constituting the following treatments: Control = animals (not treated with astaxanthin); T100 and T200 = fish treated with 100 and 200 mg of astaxanthin/kg of feed, respectively. There were no hematological alterations in red blood cells counts, hematocrit, hemoglobin, MCV and MCHC. In addition, astaxanthin-fed tilapia presented a better thrombocyte and leukocyte responses with a marked decrease in the number of thrombocytes, lymphocytes and neutrophils. Among treatments, there were no changes in serum levels of total protein, albumin, globulins, aspartate aminotransferase and alkaline phosphate. Treatment with astaxanthin resulted in a decrease in triglyceride and glucose levels, as well as increase in hepatosomatic indices. The results of hematological and biochemical analyzes of tilapias demonstrated the clinical safety of this carotenoid, not causing harmful effects to the health of fish. Therefore, the antioxidant activity of this compound in tilapias resulted in an improvement in the leukocyte profile and contributed to hypolipidemic effects at the dose of 200mg of astaxanthin/kg of feed.

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“…As tilapia is a species with high popularity and the second most farmed fish species globally (Islam, Rohani, & Shahjahan, 2021), the maximal use of the animal is desirable. According to Moraes et al (2018), waste of fishing (head, entrails, skin, and dorsal spine) may represent 62.5% animal weight and cause environmental contamination. Thus, the lower the weight of viscera, the better the use by the animal.…”

Section: Animal Performancementioning

confidence: 99%

Diet supplementation formulated with Bacillus sp. SMIA-2 and its enzymes for Nile tilapia: zootechnical performance and effects on intestinal morphometry

Pierro,

Mendonça,

Santos

et al. 2023

Acta Sci. Anim. Sci.

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The use of probiotics and exogenous enzymes in fish feed is a promising alternative to improve animal performance. This study evaluated the feasibility of applying Bacillus sp. SMIA-2 and its enzymes as supplements in the diet for juvenile tilapia. The effect of adding different concentrations of Bacillus sp. SMIA-2 and its enzymes in food on zootechnical development, intestinal morphometry of animals was analyzed. The bacteria could be recovered from the intestines of animals, demonstrating its ability to survive gastric and bile acids. The comparative study of SMIA-2 with commercial products showed a significant effect on individual food intake, final weight and weight gain in all treatments. Gut length, villus height and intestinal coefficient were an advantage of SMIA-2 compared to commercial products and the control group. Therefore, the inclusion of Bacillus sp. SMIA-2 and its enzymes in fish feed may represent a viable alternative to improve animal development and significantly increase intestinal villi, contributing to nutrient absorption and animal health.

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Esteatose hepática altera acúmulo celular em tilápias do Nilo durante aerocistite infecciosa

Cited by 11 publications

References 36 publications

SAFETY OF ORAL DOXYCYCLINE TREATMENT IN NILE TILAPIA, Oreochromis niloticus

SAFETY OF ORAL DOXYCYCLINE TREATMENT IN NILE TILAPIA, Oreochromis niloticus

EFFECT OF DIETARY SUPPLEMENTATION WITH ASTAXANTHIN ON THE HEMATOLOGICAL AND BIOCHEMICAL RESPONSE OF NILE TILAPIA (Oreochromis niloticus)

Diet supplementation formulated with Bacillus sp. SMIA-2 and its enzymes for Nile tilapia: zootechnical performance and effects on intestinal morphometry

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