“…The daily administration of amprolium (280 mg/kg body weight) in preruminant lambs caused severe diarrhea and extensive hemorrhages in most organs and lesions in the brain after four weeks [15]. Other adverse effects of amprolium have been reported, for example, a high concentration of amprolium caused urine backflow from cloaca to ceca in chicken [16], had acute death, lesions in the brain, swollen endothelial cells, and edema in sheep [17].…”