2018
DOI: 10.1590/1678-5150-pvb-4539
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Abstract: RESUMO: As leishmanioses têm como agentes etiológicos parasitas intracelulares obrigatórios pertencentes ao gênero Leishmania capazes de infectar diferentes espécies de mamíferos e nestes se reproduzirem dentro do sistema fagocítico mononuclear. Os cães domésticos são os principais responsáveis pela manutenção da cadeia epidemiológica da doença, podendo apresentar uma grande variedade de perfis clínicos, desde aparentemente sadios a severamente acometidos. Avaliou-se a expressão das citocinas de cães naturalme… Show more

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“…This has also been observed in sheep infected with Fasciola hepatica, in which overexpression of IL-10 in the liver was found at all the stages of infection. 22 Rosário et al 23 suggested that IL-10 suppresses the protective immune response, thus leading to progression of leishmaniosis with increased parasite burden in the cells. High IL-10 production implies that the macrophages and T cells of infected dogs produced IL-10 in response to Leishmania antigens, and that this production may be an important factor favouring the parasite's persistence in host cells.…”
Section: Discussionmentioning
confidence: 99%
“…This has also been observed in sheep infected with Fasciola hepatica, in which overexpression of IL-10 in the liver was found at all the stages of infection. 22 Rosário et al 23 suggested that IL-10 suppresses the protective immune response, thus leading to progression of leishmaniosis with increased parasite burden in the cells. High IL-10 production implies that the macrophages and T cells of infected dogs produced IL-10 in response to Leishmania antigens, and that this production may be an important factor favouring the parasite's persistence in host cells.…”
Section: Discussionmentioning
confidence: 99%