2018
DOI: 10.1590/1678-4685-gmb-2017-0075
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Abstract: This study aimed to use gene chips to investigate differential gene expression profiles in the occurrence and development of acute myocardial infarction (AMI). The study included 12 AMI patients and 12 healthy individuals. Total mRNA of peripheral bloodwas extracted and reversed-transcribed to cDNA for microarray analysis. After establishing two pools with three subjects each (3 AMI patients and 3 healthy individuals), the remaining samples were used for RT-qPCR to confirm the microarray data. From the microar… Show more

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Cited by 17 publications
(14 citation statements)
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“…All of the AMI patients (aged 41-92 years, N=30), SAP patients (aged 30-82 years, N=30), and healthy controls (aged 43-83 years, N=30) were recruited from the Zhejiang hospital (Hangzhou, Zhejiang, China) between January 2014 and December 2016. Patients were diagnosed according to the guidelines of the American Heart Association/American College of Cardiology Foundation (13)(14)(15). AMI patients were diagnosed using the changes in myocardial necrotic proteins and met one of the following criteria: (I) showing clear ischemic symptoms; (II) showing dynamic ECG changes with pathological Q wave; (III) showing new ST-T changes or onset of left bundle branch block on ECG; or (IV) showing segmental wall motion disorder on imaging, or with loss of viable myocardium (13,14).…”
Section: Patients and Control Subjectsmentioning
confidence: 99%
See 1 more Smart Citation
“…All of the AMI patients (aged 41-92 years, N=30), SAP patients (aged 30-82 years, N=30), and healthy controls (aged 43-83 years, N=30) were recruited from the Zhejiang hospital (Hangzhou, Zhejiang, China) between January 2014 and December 2016. Patients were diagnosed according to the guidelines of the American Heart Association/American College of Cardiology Foundation (13)(14)(15). AMI patients were diagnosed using the changes in myocardial necrotic proteins and met one of the following criteria: (I) showing clear ischemic symptoms; (II) showing dynamic ECG changes with pathological Q wave; (III) showing new ST-T changes or onset of left bundle branch block on ECG; or (IV) showing segmental wall motion disorder on imaging, or with loss of viable myocardium (13,14).…”
Section: Patients and Control Subjectsmentioning
confidence: 99%
“…Patients were diagnosed according to the guidelines of the American Heart Association/American College of Cardiology Foundation (13)(14)(15). AMI patients were diagnosed using the changes in myocardial necrotic proteins and met one of the following criteria: (I) showing clear ischemic symptoms; (II) showing dynamic ECG changes with pathological Q wave; (III) showing new ST-T changes or onset of left bundle branch block on ECG; or (IV) showing segmental wall motion disorder on imaging, or with loss of viable myocardium (13,14). Patients with SAP were also diagnosed according to the American Heart Association/American College of Cardiology Foundation guidelines (15,16).…”
Section: Patients and Control Subjectsmentioning
confidence: 99%
“…Finally, it was recently reported that an upregulation of GBGT1 was noted in samples from patients with myocardial infarction, and the authors suggested this to be one of six markers used as a diagnostics tool. 27…”
Section: Disease Associationsmentioning
confidence: 99%
“…Our previous gene chip study showed that retinoic acid receptor-related orphan receptor A (RORA) gene expression was higher in white blood cells in the AMI group compared with the SCAD group. 14 Therefore, this study aimed to determine whether high expression of the RORA gene in peripheral blood leukocytes is related to AMI. patients were de-identified.…”
Section: Introductionmentioning
confidence: 99%