The association between adult-type hypolactasia and symptoms of functional dyspepsia

Wortmann, André Castagna; Simon, Daniel; Mazzoleni, Luiz Edmundo; Sander, Guilherme Becker; Francesconi, Carlos Fernando de Magalhães; Nabinger, Débora Dreher; Grott, Camila Schultz; Rech, Tássia Flores; Mazzoleni, Felipe; Lunge, Vagner Ricardo; Bona, Laura Renata de; Milbradt, Tobias Cancian; Silveira, Themis Reverbel da

doi:10.1590/1678-4685-gmb-2017-0015

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…One of the strengths of our study is the described association between milk intolerance and FD. Data on the relationship between lactose intolerance and FD are scarce [54,55]. Therefore, this potential association needs additional investigation.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Irritable Bowel Syndrome, Functional Dyspepsia and their Overlap in Bulgaria: a Population-Based Study

Nakov

Dimitrova-Yurukova

Snegarova

et al. 2020

JGLD

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Aims: We aimed to evaluate the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), and their overlap syndrome (OS) in the Bulgarian population and to assess the risk factors associated with these disorders. Methods: We sent an internet-based survey to Bulgarian adults. The survey collected data on socio- demographic, behavioral and lifestyle characteristics, and diagnostic questions following the Rome IV criteria to assess IBS, FD and their overlap occurrence. Results: Data was collected from 1,896 individuals (mean age = 35.5 years, 18-65, SD=11.7), 73.1% females. The prevalence of IBS was 20% (14% were with predominant constipation, 32% with predominant diarrhea, 52% had IBS with mixed bowel habits, and 2% unclassified IBS). Gender (p=0.005), age (p<0.001), marital status (p=0.009), occupation (p=0.001), alcohol consumption (p=0.013), sexual problems (p<0.001), FD (p<0.001), and milk intolerance (p<0.001) were significantly associated with IBS. Females (p=0.032; OR: 1.50), patients with FD (p<0.001; OR: 104.98), sexual problems (p= 0.001; ОR: 1.55 ), and milk intolerance (p<0.001; OR: 2.22) are at a higher risk of having IBS. The prevalence of FD was 12.7% (39% had postprandial distress syndrome, 33% epigastric pain syndrome, and 28% had the overlapping variant). Patients with IBS (p<0.001; OR: 127.88) and milk intolerance (p<0.001) were significantly associated with FD prevalence. The prevalence of OS was 11.7%. Gender (p=0.013), milk intolerance (p<0.001, OR: 1.65), urinary (p=0.035) and sexual problems (p<0.001, ОR: 1.80) were associated with OS prevalence. Conclusion: This is the first study to estimate the prevalence of IBS, FD, and their OS and assess the behavioral and demographic risk factors associated with these disorders in the Bulgarian population. Our results are valuable in filling in the epidemiological data gap regarding IBS, FD, and OS in Eastern Europe.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Irritable Bowel Syndrome, Functional Dyspepsia and their Overlap in Bulgaria: a Population-Based Study

Nakov

Dimitrova-Yurukova

Snegarova

et al. 2020

JGLD

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“…Although lactose malabsorption and lactose intolerance account significantly for the symptoms of the patients with FD, there is limited data on the effect of a LLD in FD [ 19 , 20 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

Exclusion Diets in Functional Dyspepsia

et al. 2022

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Functional dyspepsia represents one of the most common and prevalent disorders of the brain–gut interaction, with a large number of widespread risk factors being identified. With an intricate pathogenesis and symptomatology, it heavily impacts the quality of life and, due to the limited efficacy of traditional pharmacological agents, patients are likely to seek other medical and non-medical solutions to their problem. Over the last few years, significant research in this domain has emphasized the importance of various psychological therapies and nutritional recommendations. Nevertheless, a correlation has been established between functional dyspepsia and food intolerances, with more and more patients adopting different kinds of exclusion diets, leading to weight loss, restrictive eating behaviour and an imbalanced nutritional state, further negatively impacting their quality of life. Thus, in this systematic review, we aimed at analysing the impact and efficiency of certain exclusion diets undertook by patients, more precisely, the gluten-free diet and the low-FODMAP diet.

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“…Unfortunately, intolerance of dairy products is usually not one of the differential diagnoses of functional dyspepsia. In their study, Wortmann et al [ 107 ] showed that adult-type lactose intolerance was present in 44.7% of patients with functional dyspepsia. Mishkin et al [ 108 ] showed that the prevalence of lactose intolerance in patients with functional dyspepsia is affected by ethnic group and age, with a decreased prevalence between 25-55 years and an increase after 55 years.…”

Section: Cow’s Milk-related Functional Gastrointestinal Disordersmentioning

confidence: 99%

Cow’s milk-induced gastrointestinal disorders: From infancy to adulthood

Al‐Biltagi¹,

Saeed²,

Bediwy³

et al. 2022

World J Clin Pediatr

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Milk is related to many gastrointestinal disorders from the cradle to the grave due to the many milk ingredients that can trigger gastrointestinal discomfort and disorders. Cow’s milk protein allergy (CMPA) is the most common food allergy, especially in infancy and childhood, which may persist into adulthood. There are three main types of CMPA; immunoglobulin E (IgE)-mediated CMPA, non-IgE-mediated CMPA, and mixed type. CMPA appears before the first birthday in almost all cases. Symptoms may start even during the neonatal period and can be severe enough to simulate neonatal sepsis. CMPA (often non-IgE mediated) can present with symptoms of gastroesophageal reflux, eosinophilic esophagitis, hemorrhagic gastritis, food protein-induced protein-losing enteropathy, and food protein-induced enterocolitis syndrome. Most CMPAs are benign and outgrown during childhood. CMPA is not as common in adults as in children, but when present, it is usually severe with a protracted course. Lactose intolerance is a prevalent condition characterized by the development of many symptoms related to the consumption of foods containing lactose. Lactose intolerance has four typical types: Developmental, congenital, primary, and secondary. Lactose intolerance and CMPA may be the underlying pathophysiologic mechanisms for many functional gastrointestinal disorders in children and adults. They are also common in inflammatory bowel diseases. Milk consumption may have preventive or promoter effects on cancer development. Milk may also become a source of microbial infection in humans, causing a wide array of diseases, and may help increase the prevalence of antimicrobial resistance. This editorial summarizes the common milk-related disorders and their symptoms from childhood to adulthood.

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The association between adult-type hypolactasia and symptoms of functional dyspepsia

Cited by 6 publications

References 38 publications

Prevalence of Irritable Bowel Syndrome, Functional Dyspepsia and their Overlap in Bulgaria: a Population-Based Study

Prevalence of Irritable Bowel Syndrome, Functional Dyspepsia and their Overlap in Bulgaria: a Population-Based Study

Exclusion Diets in Functional Dyspepsia

Cow’s milk-induced gastrointestinal disorders: From infancy to adulthood

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