Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr.) Pers. through its neuroregenerative action

Wong, Kah-Hui; Kanagasabapathy, Gowri; Bakar, Robiah; Phan, Chia Wei; Sabaratnam, Vikineswary

doi:10.1590/1678-457x.6838

Cited by 28 publications

(15 citation statements)

References 22 publications

(24 reference statements)

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“…Furthermore, H . erinaceus was found to promote the recovery of motor and sensory functions after crush injury, and enhanced the regeneration of peripheral nerves 19 . Additionally, Hericium erinaceus has also been shown to improve the hippocampal-dependent recognition memory with enhancement of neurotransmission and neurogenesis in the hippocampus and the cerebellum 13 , 20 .…”

Section: Introductionmentioning

confidence: 94%

Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia

Chong

Khairuddin

Tse

et al. 2020

Sci Rep

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Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although several studies have demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), its mechanisms in cerebellar ataxia remain largely unknown. Here, we investigated the neuroprotective effects of H.E. treatment in an animal model of 3-acetylpyridine (3-AP)-induced cerebellar ataxia. Animals administered 3-AP injection exhibited remarkable impairments in motor coordination and balance. There were no significant effects of 25 mg/kg H.E. on the 3-AP treatment group compared to the 3-AP saline group. Interestingly, there was also no significant difference in the 3-AP treatment group compared to the non-3-AP control, indicating a potential rescue of motor deficits. Our results revealed that 25 mg/kg H.E. normalised the neuroplasticity-related gene expression to the level of non-3-AP control. These findings were further supported by increased protein expressions of pERK1/2-pCREB-PSD95 as well as neuroprotective effects on cerebellar Purkinje cells in the 3-AP treatment group compared to the 3-AP saline group. In conclusion, our findings suggest that H.E. potentially rescued behavioural motor deficits through the neuroprotective mechanisms of ERK-CREB-PSD95 in an animal model of 3-AP-induced cerebellar ataxia.

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Section: Introductionmentioning

confidence: 94%

Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia

Chong

Khairuddin

Tse

et al. 2020

Sci Rep

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“…To assess the sensory recovery, behavioral test such as hot plate test is used [37]. In autograft, Conduit þ NGF and conduit groups, one Month after surgical transection, the withdrawal reflex latency dropped to 12 s and decreased until the third month.…”

Section: Discussionmentioning

confidence: 99%

Use new poly (ε-caprolactone/collagen/NBG) nerve conduits along with NGF for promoting peripheral (sciatic) nerve regeneration in a rat

Mohamadi

Ebrahimi‐Barough

Nourani

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Regeneration of peripheral nerve defects remained a remarkable clinical challenge. Engineered nerve conduits represent a promising strategy to improve functional recovery in peripheral nerve injury repair. However, nerve conduits require additional factors such as neurotrophic factors to create a more conducive microenvironment for nerve regeneration. Neurotrophic factors have well-demonstrated abilities to improve neurite outgrowth, making them great candidates for repairing of defected nerves. To this end, we examined the beneficial effects of repairing the transected rat sciatic nerve by loading of nerve growth factor (NGF) in nerve conduits. The PCL/Collagen/NBG conduits were interposed into the 10 mm right sciatic nerve defects. Twenty-four rats were randomly allocated into four groups: 1- nerve autograft group, 2- a nongrafted group with gap 10-mm, 3- conduit group and 4- the conduits loaded with NGF. Motor and sensory functional recovery, the evoked muscle action potential, and motor distal latency showed significant improvement in rats treated with NGF. The histology and immunohistochemistry studies revealed less fibrosis and a high level of expression of CD31 and NF-200 protein at the crush site in the Conduit + NGF group. In conclusion, the PCL/Collagen/NBG conduit loaded with NGF, which exhibited nanometer-scale features, neurotrophic activity, favorable mechanical properties and biocompatibility could improve sciatic nerve regeneration in rats.

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“…To evaluate the sensory recovery, hot plate test was used to assess the pain responses [51]. The rst response, licking as a rapid response to thermal stimuli, is known as a direct indicator of nociceptive threshold.…”

Section: Hot Plate Latency (Hpl) Testmentioning

confidence: 99%

Development of Multi-channel Electro-conductive Nanofibrous Conduits for Peripheral Nerve Regeneration

Nazeri¹,

Derakhshan²,

Mansoori³

et al. 2021

Preprint

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Multichannel structures in the design of nerve conduits offer potential advantages for regeneration of damaged nerves due to their bio-mimicking architecture. However, lack of biochemical cues and electrical stimulation could hamper satisfactory nerve regeneration. The aim of this study was to simultaneously evaluate the effects of topographical, biological and electrical cues on sciatic nerve regeneration in a rat model. Accordingly, a series of multichannel nanofibrous nerve conduit was made using longitudinally-aligned laminin-coated electrospun PLGA/CNT nanofibers (NF, mean diameter: 455 ± 362 nm) in the lumen and randomly-oriented PCL NF (mean diameter: 340 ± 200 nm) on the outer surface. In vitro studies revealed that both materials were nontoxic to Schwann cells and able to promote cell attachment and proliferation. To determine the influence of topographical, biological and electrical cues on nerve regeneration, either of hollow PCL conduits, PLGA NF-embedded, PLGA/CNT NF-embedded or laminin-coated PLGA/CNT NF-embedded PCL conduits were implanted in rats. A new surgery method was utilized and results were compared with an autograft. After animal treatments, motor and sensory tests showed significant improvement in the rats treated with NF-embedded PCL conduits. H&E images obtained from cross-sectional and, longitudinal-sections of the regenerated nerves demonstrated the formation of regenerative nerve fibers and also, angiogenesis in laminin-coated PLGA/CNT NF-embedded PCL conduits. Results suggested that these conduits have the potential for clinical application to reconstruct peripheral nerve defects.

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Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr.) Pers. through its neuroregenerative action

Cited by 28 publications

References 22 publications

Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia

Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia

Use new poly (ε-caprolactone/collagen/NBG) nerve conduits along with NGF for promoting peripheral (sciatic) nerve regeneration in a rat

Development of Multi-channel Electro-conductive Nanofibrous Conduits for Peripheral Nerve Regeneration

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