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Cited by 13 publications
(6 citation statements)
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“…Moreover, it has a strong effect on nourishing the stomach Yin, playing an important role in treating gastrointestinal diseases. Zhang et al reported that Dendrobium officinale polysaccharides could inhibit human gastric cancer cell in nude mice [22], while Zeng et al's study showed the polysaccharides of Dendrobium officinale Kimura et Migo could protect gastric mucosal cell against oxidative damage-induced apoptosis in vitro and in vivo [21]. Increased reactive oxygen species and oxidative stress injury may lead to gastric mucosal damage and malignancies, resulting in an increase of the DNA damage marker 8-OHdG [29, 30].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Moreover, it has a strong effect on nourishing the stomach Yin, playing an important role in treating gastrointestinal diseases. Zhang et al reported that Dendrobium officinale polysaccharides could inhibit human gastric cancer cell in nude mice [22], while Zeng et al's study showed the polysaccharides of Dendrobium officinale Kimura et Migo could protect gastric mucosal cell against oxidative damage-induced apoptosis in vitro and in vivo [21]. Increased reactive oxygen species and oxidative stress injury may lead to gastric mucosal damage and malignancies, resulting in an increase of the DNA damage marker 8-OHdG [29, 30].…”
Section: Discussionmentioning
confidence: 99%
“…Further analysis revealed that Dendrobium officinale extracts could regulate the levels of 8-OHdG, superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-PX) in plasma and cytokines related to carcinogenesis [20]. DOP, the main effective part in Dendrobium officinale, had been reported to harbor anticancer effects on gastric cancer cells and protective effects on experimental gastric ulcers in mice [21, 22]. This study explores, for the first time, the ability of DOP to prevent PLGCs via a mechanism based on NRF2 and important downstream antioxidant enzymes such as HO-1 and NQO-1.…”
Section: Introductionmentioning
confidence: 99%
“…Tumorgenesis is a complex process, closely related to immune and inflammatory processes. Its anti-tumor activity mechanism is mainly to enhance immune regulation, inhibit tumor cell proliferation, and regulate tumor cell microenvironment ( 1 , 65 , 66 ).…”
Section: Biological Activitiesmentioning
confidence: 99%
“…By the end of the experimental periods, one to two mL blood samples were collected through cardiac puncture of the rats by using 23G needle under general anesthesia Blood was collected in BD Vacutainer® heparin tubes and immediately analyzed using an automatic hematology analyzer (Sysmex K-1000, Minnesota, USA) in order to determine red blood cell count (RBC), white blood cells (WBC), hemoglobin concentration (HGB), hematocrit (HT), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), platelets (PLT), neutrophils, lymphocytes, monocytes, and eosinophils (Zhang et al, 2018).…”
Section: Hematologymentioning
confidence: 99%