Methylene Blue for the Treatment of Health Conditions: a Scoping Review

Abstract

studies evaluating effective drugs for health conditions are of crucial importance for public health. Methylene blue (MB) is an accessible synthetic drug that presents low toxicity and has been used in several health areas due to its effectiveness. Objective: this scoping review aims to provide a comprehensive overview of relevant research regarding the use of MB for the treatment of health conditions. Methods: a fivestage framework Arksey and O'maley scoping review was conducted. The literature was searched in Cochrane Library database using Mesh term "methylene blue". Data were collected by two independent reviewers and submitted to descriptive synthesis. Results: The search resulted in 429 records, from which 16 were included after exclusion criteria were applied. The therapeutic use of MB was identified for acute conditions (malaria and septic shock), chronic conditions (discogenic back pain, bipolar disorder, refractory neuropathic pain, and post-traumatic stress disorder), and postoperative care (vasoplegic syndrome, and pain after haemorrhoidectomy, lumbar discectomy, and traumatic thoracolumbar fixation). Conclusion: there is much evidence emerging from clinical trials about the therapeutic use of MB for acute, chronic, and HIGHLIGHTS  This scoping review summarizes the findings of clinical trials using methylene blue (MB) for the treatment of various health conditions.  This research method allowed mapping main findings, clarifying research topics, and identifying gaps in the literature.

Design of Nickel-Containing Nanocomposites Based on Ordered Mesoporous Silica: Synthesis, Structure, and Methylene Blue Adsorption

“…The prepared nanocomposites were tested for sorptive removal capacity of a widely used organic pollutant, the cationic dye methylene blue (MB), used in large amounts in industry for coloring paper, dyeing cotton, wools, silk, and leather, but used also in medication and diagnostic biology [49][50][51].…”

Study on the photocatalytic properties differences between the 1-D and 3-D W18O49 particles

“…[14][15][16][17][18] Furthermore, methylene blue (MB) is one of the most commonly used organic dyes in the textile industry and is said to be composed of various aromatic amine groups, which can cause serious skin damage, cancerization and respiratory disease. 13,19,20 Therefore, nding the effective way to remove organic dyes from wastewater has become the top priority in environmental protection and has attracted wide attention. To better solve the above problems, more and more approaches have been carried out to degrade organic dyes, such as physical absorption, solvent extraction, biodegradation, and photocatalytic oxidation.…”