Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats

Sadri, Hamideh; Goodarzi, Mohammad Taghi; Saberi, Zahra; Seifi, Morteza

doi:10.1590/1678-4324-2017160741

Cited by 37 publications

(23 citation statements)

References 36 publications

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“…A previous study indicated that SOD was inactivated by glycation (61). Another study reported that SOD activity was decreased in STZ-induced rat models of DM (62). An injection with STZ was reported to increase MDA levels and decrease the activity of SOD in rats with DM (63,64).…”

Section: Discussionmentioning

confidence: 97%

Effect of Azadirachta indica flower extract on functional recovery of sciatic nerve crush injury in rat models of DM

et al. 2018

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Chronic hyperglycemia causes nerves to be more susceptible to compression, which often occurs as a result of hyperglycemia-induced oxidative stress. Oxidative stress impairs nerve function and delays nerve recovery. Azadirachta indica, a herb from Thailand, possesses antioxidant and antidiabetic properties. The aim of the present study was therefore to investigate the effect of A. indica flower extract on the functional recovery of a sciatic nerve crush injury in rat models of diabetes mellitus (DM). Male Wistar rats were randomly assigned into seven groups including the control rats, rats with DM subjected to sham surgery and treated with vehicle, and rats with DM subjected to the crush surgery and treated with vehicle or A. indica flower extract at a dose of 250, 500 or 750 mg/kg animal body weight, or with vitamin C. DM was induced using a single intraperitoneal injection of streptozotocin (55 mg/kg animal body weight). Rats subjected to a sciatic nerve crush injury or sham surgery were orally treated with either vehicle, A. indica flower extract or vitamin C for 21 days. Functional recovery was assessed every 3 days using a walking track analysis, foot withdrawal reflex test and rotarod test. At the end of the study, the rats were sacrificed and their left sciatic nerves were harvested in order to determine malondialdehyde levels, superoxide dismutase activity and axon density. The treatment with A. indica flower extract significantly improved functional recovery, especially motor and sensory functions. The extract significantly decreased malondialdehyde levels, and increased superoxide dismutase activity and axon density. The results of the current study indicate that the mechanism underlying the enhanced functional recovery of the sciatic nerve following treatment with A. indica flower extract may be associated with an antioxidative effect. However, further studies are required to confirm the current results.

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Section: Discussionmentioning

confidence: 97%

Effect of Azadirachta indica flower extract on functional recovery of sciatic nerve crush injury in rat models of DM

et al. 2018

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“…Similar findings were observed by many experimental DM investigations. 13 , 14 , 44 , 46 , 47 , 60 , 61 Hypoproteinemia and hypoalbuminemia are linked with liver and kidney dysfunctions. Albumin is produced by the liver.…”

Section: Discussionmentioning

confidence: 99%

Effects of <em>Caralluma russeliana</em> stem extract on some physiological parameters in streptozotocin-induced diabetic male rats

Zari¹,

Al-Thebaiti²

2018

DMSO

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PurposeThe aim of this study was to investigate the effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin induced diabetes in male Wistar rats after 8 weeks.Materials and methodsThe experimental rats were randomly assigned into four groups. Rats of group 1 were normal controls. Rats of group 2 were diabetic controls. Rats of group 3 were diabetic rats treated with C. russeliana stem extract. Rats of group 4 were non-diabetic rats, subjected to C. russeliana stem extract.ResultsThe lowest body weight gain was noticed in diabetic rats of group 2. Serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, ALP, total bilirubin, creatinine, blood urea nitrogen (BUN) and uric acid levels were significantly elevated in diabetic rats of group 2; however, total serum protein, albumin and high-density lipoprotein cholesterol were significantly reduced in diabetic rats of group 2.ConclusionTreatments with C. russeliana stem extract in diabetic rats revealed notable diminishing and protecting effects of physiological modifications. Therefore, this study revealed the significance of using C. russeliana stem extract as a promising remedial agent to treat diabetes and its complications.

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“…Streptozotocin (Sigma-Aldrich) was dissolved in citrate buffer, pH 4.5 (0.1 mol/l trisodium citrate, 0.1 mol/l citric acid) and used to induce diabetes mellitus (55 mg/kg BW) in rats [27]. Diabetes was confirmed by measuring of blood glucose levels three days after the STZ injection.…”

Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

“…Diabetes was confirmed by measuring of blood glucose levels three days after the STZ injection. Animals with serum glucose level higher than 250 mg/dl were considered as diabetic [27].…”

Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

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Antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae in Streptozotocin-induced diabetic rats

Nasirian

Sarir

Kor

2019

Biomolecular Concepts

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BackgroundIt is well documented that biologically active components of microalgae can be utilized for treatment of different diseases. This study was conducted to evaluate the antihyperglycemic and antihyperlipidemic activities and weight control of Nannochloropsis oculata microalgae (NOM) in Streptozotocin-induced diabetic male rats.MethodsDiabetes was induced by intraperitoneal administration of Streptozotocin (55 mg/kg). Healthy and diabetic rats were divided in to six groups. Healthy and diabetic rats orally received distilled water or NOM (10 and 20 mg/kg) for three weeks.ResultsOral administration of NOM to diabetic rats significantly reduced the serum concentrations of glucose, cholesterol, triglycerides, LDL and increased the serum concentration of insulin and HDL-C (P<0.05). Treatment with NOM had no significant effect on blood parameters in healthy rats (P>0.05). Also, NOM maintained body weight in diabetic rats (P<0.05).ConclusionIt can be concluded that NOM has antihyperglycemic and antihyperlipidemic activities in diabetic rats.

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Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats

Cited by 37 publications

References 36 publications

Effect of Azadirachta indica flower extract on functional recovery of sciatic nerve crush injury in rat models of DM

Effect of Azadirachta indica flower extract on functional recovery of sciatic nerve crush injury in rat models of DM

Effects of <em>Caralluma russeliana</em> stem extract on some physiological parameters in streptozotocin-induced diabetic male rats

Antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae in Streptozotocin-induced diabetic rats

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