2018
DOI: 10.1590/1678-4324-2017160623
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Abstract: Morous Alba, known as white mulberry contains many oxidative flavonoids, widely used in the treatment of many diseases like hyperglycemia, inflammation, fever and cancer. In the present study we investigated the interaction of extracted flavonoids from Iranian Morus Alba leaves with DNA as a main target for anticancer drugs. Various spectroscopic techniques (UV/Vis, CD and Fluorescence Spectroscopy) were used to detect the interaction. In vivo studies also were done to confirm the effectiveness of the extracte… Show more

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Cited by 8 publications
(4 citation statements)
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“…Their spectroscopic findings revealed the interaction of extracted flavonoids with DNA, especially at the sugar-phosphate backbone, results in conformational changes. In addition, in vivo treatment of cancerous mice with extracted flavonoids did not indicate any reduction in tumor size, but a significant increase in life span was reported (Fallah et al, 2018). An in vivo and in vitro study (Liu, Zhou, et al, 2019) indicated the anti-tumor potential of watersoluble crude polysaccharides from mulberry leaves and fermented Phellinus igniarius.…”
Section: Ta B L E 1 (Continued)mentioning
confidence: 99%
“…Their spectroscopic findings revealed the interaction of extracted flavonoids with DNA, especially at the sugar-phosphate backbone, results in conformational changes. In addition, in vivo treatment of cancerous mice with extracted flavonoids did not indicate any reduction in tumor size, but a significant increase in life span was reported (Fallah et al, 2018). An in vivo and in vitro study (Liu, Zhou, et al, 2019) indicated the anti-tumor potential of watersoluble crude polysaccharides from mulberry leaves and fermented Phellinus igniarius.…”
Section: Ta B L E 1 (Continued)mentioning
confidence: 99%
“…The results showed that the extracted flavonoids inhibited tumor growth through DNA modifications by binding to the sugar–phosphate backbone. However, the in vivo experiments did not confirm the flavonoids’ effect in inhibiting tumor growth but increased the lifespan of cancerous mice [ 183 ]. In Table 5 are listed the novel studies that confirmed the antitumoral effects of different compounds that are found in the mulberry.…”
Section: Mulberry As An Alternative Anticancer Approachmentioning
confidence: 99%
“…Hyperglycemia, inflammation, fever, and cancer are all treated with oxidative flavonoids found in white mulberry. The flavonoid extracts of white mulberry bind to DNA, producing DNA conformational changes and making them natural anticancer agents (Fallah et al, 2016).…”
Section: Introductionmentioning
confidence: 99%