2017
DOI: 10.1590/1678-4324-2017160179
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Abstract: Spinosad (SPD) is a highly selective insect control product. However, it was reported that SPD has toxicity toward other non-target organisms. This study was conducted to address the toxic effect of two sub-chronic low and high doses; 35 and 350 mg/kg SPD on some biochemical, histological and immunohistochemical parameters of the liver, kidney and cerebellum. Thirty-six male Swiss mice were divided into three groups of 12 mice each; first group (G1) served as a control, second group (G2) received a low sub-chr… Show more

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Cited by 6 publications
(6 citation statements)
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“…The in-vivo results reveal significant improvements of hematological profile (RBCs, HCT, MCHC, PLT, and total and differential leukocytic counts), ESR in the second hour, biochemical profile (TP, CREAT, ALT, UREA, GLUCO, TG, and TC), and CORT levels of the 2-week (P 1 ) and 4-week posttreatment (P 2 ) samples in the infested dogs, considering that the evaluation was carried out for a month after the treatments. These results are in agreement with those of El-Naggar et al (2017) who reported no adverse effects of the experimented bio-insecticides on the histopathological and physiological functions of liver, kidney, and cerebellum in male Albino mice. Marchiondo et al (2013 , 2019) also reported the necessity to assess the long-term effectiveness of the tested insecticide with intervals of 7–31 days.…”
Section: Discussionsupporting
confidence: 93%
“…The in-vivo results reveal significant improvements of hematological profile (RBCs, HCT, MCHC, PLT, and total and differential leukocytic counts), ESR in the second hour, biochemical profile (TP, CREAT, ALT, UREA, GLUCO, TG, and TC), and CORT levels of the 2-week (P 1 ) and 4-week posttreatment (P 2 ) samples in the infested dogs, considering that the evaluation was carried out for a month after the treatments. These results are in agreement with those of El-Naggar et al (2017) who reported no adverse effects of the experimented bio-insecticides on the histopathological and physiological functions of liver, kidney, and cerebellum in male Albino mice. Marchiondo et al (2013 , 2019) also reported the necessity to assess the long-term effectiveness of the tested insecticide with intervals of 7–31 days.…”
Section: Discussionsupporting
confidence: 93%
“…At the end of the experiment, all groups were anesthetized to collect blood samples via orbital plexus bleeding for hematological and biochemical analysis. Then, mice were subjected to complete dissection to harvest liver and kidney tissues for histopathological examination (El-Naggar et al, 2017).…”
Section: Methodsmentioning
confidence: 99%
“…Oral administration of spinosad daily for 28 consecutive days to male mice at doses equal to 350 mg/kg. b.wt induced significant decrease in body weight and increase in organ relative weight of kidney and spleen [ 68 ]. Breslin et al .…”
Section: Adverse Effects Of Natural Insecticides On Experimental Amentioning
confidence: 99%
“…b.wt caused liver damage in male mice. It induced significant elevation in liver function enzyme (AST and ALT) and in triglycerides [ 68 ]. Male and female rats are exposed to spinosad through feed in diet containing spinosad at concentration ranging from 0.003 to 0.4 % for 13 weeks.…”
Section: Adverse Effects Of Natural Insecticides On Experimental Amentioning
confidence: 99%
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