Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Baş, Hatice; Kalender, Suna

doi:10.1590/1678-4324-2016160151

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…Dosing of heavy metals mixture produced lower level of glutathione peroxidase (GPx) in liver (p < 0.0001) and kidney (p < 0.001) tissues at heavy metals group in comparison with control group, this could probably due to the utilization of its defense mechanism against toxic metals within these organs as a result of ROS generation; such suggestion is matched with Ercal et al, (2001); Saxena et al, (2005) and Bas & Kalender (2016). However, rats that exposed to toxic metals and treated with propolis exhibited signi cant improving in the activities of GPx in livers (p < 0.001) as well kidney (p < 0.01) when compared with heavy metals group; that issue clarify the protective role of propolis in recovering the affected tissues of liver and kidney as healthy rats through reducing combined toxicity of investigated metals; these ndings were corroborated very well with Salama & El-Bahr, (2007);Bhadauria, (2012) and Mohamed et al, (2017).…”

Section: -4-antioxidant Enzymes and Propolissupporting

confidence: 67%

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

El-Amawy

Zaahkouk

Rasheed

et al. 2021

Preprint

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The study was designed to clarify the hepato-renal protective effects of propolis extract against heavy metals-induced toxicity via oral administration to the males of albino rats. Lead (Pb), Nickel (Ni), Cadmium (Cd), and Antimony (Sb) are toxic heavy metals have the ability to produce reactive radicals in the biological systems causing public and animals health hazards through disrupting balances between pro-oxidant and antioxidant defense system, resulting in excessive reactive oxygen species (ROS) production. The most commonly affected organs are liver and kidney. Propolis is a natural product with different shapes and resinous substance collected by honey bees, it attenuates many diseases damage due to its anti-oxidative action and its potentiality to minimize the deleterious effects of free radicals on tissues. The concentrations of Pb, Cd, Ni and Sb as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the tissues of liver and kidney; while aspartate transaminase (ASAT), alanine transaminase (ALAT), total protein (TP), urea and createnine, were measured in the serum of experimental rats beside histopathologicl examination in the tissues of liver and kidney. The oral administration of propolis provided a significantly therapeutic role against multi-metals-induced hepato-renal toxicity with relative improving to histopathological changes because of its scavenging and chelating properties as concluded from the present investigation.

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Section: -4-antioxidant Enzymes and Propolissupporting

confidence: 67%

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

El-Amawy

Zaahkouk

Rasheed

et al. 2021

Preprint

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“…Reactive oxygen species (ROS) play roles in cellular pathogenesis, including testicular cells (Bas & Kalender, ; Guesmi et al., ). Fatty acids are crucial in maintaining sperm functions in male reproductive cells (Ozan, Kaya, Yılmaz, Erdem, & Ozan, ; Turner & Lysiak, ).…”

Section: Discussionmentioning

confidence: 99%

Effects of astaxanthin on biochemical and histopathological parameters related to oxidative stress on testes of rats on high fructose regime

et al. 2018

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Astaxanthin (ASX) is a xanthophyll family of hydroxycarotenoids which contains several double bonds. It is produced by Haemococcus pluvialis, a microalgae and possesses antioxidant and anti-inflammatory properties. The aim of this study was to test whether ASX could protect against oxidative damage in the testicular tissues of rats receiving high fructose. The rats (n = 24) were randomly divided into two main groups: control and fructose (30%, via drinking water) and then each main group either not supplemented or supplemented with ASX (1 mg kg day , within 0.2 ml olive oil) via oral gavage. Data were subjected to two-way ANOVA. High fructose consumption tended to increase testis weight and serum testosterone concentration and decreased testicular tissue glutathione-S-transferase (GST) and superoxide dismutase (SOD) levels, but did not affect testicular tissue malondialdehyde (MDA) concentration. Astaxanthin administration increased testosterone, GST and SOD levels and testis weight and decreased MDA concentration. However, ASX administration did not reverse alterations in antioxidant parameters caused by high fructose consumption. Inducible nitric oxide synthase (iNOS) tended to increase in sertoli cell, spermatid and spermatogonia, but not in spermatocytes and leydig cell in response to high fructose consumption. Astaxanthin administration tended to reverse elevation in iNOS in testis cells. In conclusion, ASX could help alleviate oxidative damage caused by high fructose consumption.

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“…Male germ cells are more susceptible to oxidative stress than other cells, because they have higher polyunsaturated fatty acids in their membranes than somatic cells. Oxidative stress plays an important role in the aetiology of defective sperm formation, function, sperm count and male infertility (Bas & Kalender, ). In our study, we showed that diabetes was associated with an oxidative stress state evidenced by a significantly increased testicular MDA level (lipid peroxidation) in the untreated diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Vitamin E improves testicular damage in streptozocin-induced diabetic rats, via increasing vascular endothelial growth factor and poly(ADP-ribose) polymerase-1

Omar

Badae

2017

Andrologia

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The precise mechanism by which diabetes impairs spermatogenesis and testicular function is not exactly known. Vascular endothelial growth factor (VEGF) and poly(ADP-ribose) polymerase-1 (PARP-1) are important for germ cell homeostasis and repair of DNA respectively. The aim of this study was to investigate the correlation between diabetes-induced testicular damage and testicular VEGF and PARP-1 expression and the possible protective role of vitamin E supplementation. A total of 45 male Wistar albino rats were randomly divided into three groups: Group I (nondiabetic rats), Group II (streptozocin-induced diabetic rats) and Group III (streptozocin-induced diabetic rats treated orally with 0.4 mg/kg vitamin E). Five weeks later, testicular tissue was used for assessment of MDA concentration by colorimetry, histopathological examination and immunostaining for PARP-1 and VEGFIn diabetic rats, testicular weight, seminiferous tubule diameter and germinal epithelial thickness were decreased, basement membrane was thickened and Johnsen score decreased. Reduced VEGF and PARP-1 immunostaining were associated with decreased Johnsen score in diabetic rats. Vitamin E administration was protective against oxidative stress-associated damage evidenced by lower MDA levels, improved testicular weight, spermatogenesis and higher immunostaining for VEGF and PARP-1. Testicular VEGF and PARP-1 might therefore be helpful biomarkers for diabetic testicular damage. Administration of vitamin E may have a protective role against diabetes-induced testicular damage.

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Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Abstract: This study was done to evaluate the effects of lead nitrate and mercury chloride in testis tissues

Cited by 14 publications

References 34 publications

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

Effects of astaxanthin on biochemical and histopathological parameters related to oxidative stress on testes of rats on high fructose regime

Vitamin E improves testicular damage in streptozocin-induced diabetic rats, via increasing vascular endothelial growth factor and poly(ADP-ribose) polymerase-1

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