Green Tropical Phytoextracts - Promising Anticancer Alternative

Khan, Abid Ali; Omer, Kosar Ali; Talib, Ayesha; Ahmed, Haroon; Javed, Mohamad Arshad; Sarmidi, Roji Mohamad

doi:10.1590/1678-4324-2016160062

Cited by 5 publications

(5 citation statements)

References 34 publications

(38 reference statements)

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“…A study showed the presence of polyphenols and flavonoids such as genistin, alkaloids, and tannins. [ 9 ] A recent published report by Kumari and Dhanalekshmi[ 10 ] also confirmed the presence of phenols, flavonoids, tannins, and saponins in F. deltoidea leaf, stem, and fruit extract. Harun and Musapha[ 11 ] reported the tannins, phlobatannins, flavonoids, saponins, steroids, terpenoids, cardiac glycosides, alkaloids, anthraquinones, and polyphenol in F. deltoidea var.…”

Section: P Hytochemical a Nalysis Of F Icus Deltoideamentioning

confidence: 70%

“…[ 22 ] However, aqueous leaf extract of F. deltoidea has shown less cytotoxicity effect. Khan et al [ 9 ] also investigated cytotoxicity effect of water extract of F. deltoidea leaves on prostate cancer cells and found poor activity. Soib[ 23 ] reported the antiproliferative activity at different concentrations of extract of F. deltoidea after 48h against prostate cancer cell line (DU145).…”

Section: P Harmacological P Roperties Of F Icus Deltoideamentioning

confidence: 99%

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An overview of phytochemical and biological activities: Ficus deltoidea Jack and other Ficus spp

Ashraf

Haque²,

Amir

et al. 2021

J Pharm Bioall Sci

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A BSTRACT Ficus deltoidea Jack (Moraceae) is a well-known medicinal plant used in customary medication among the Malay people to reduce and mend sicknesses such as ulcers, psoriasis, cytotoxicity, cardioprotective, inflammation, jaundice, vitiligo, hemorrhage, diabetes, convulsion, hepatitis, dysentery injuries, wounds, and stiffness. Ficus deltoidea contains a wide variety of bioactive compounds from different phytochemical groups such as alkaloids, phenols, flavonoids, saponins, sterols, terpenes, carbohydrates, and proteins. The genus Ficus has several hundreds of species, which shows excellent therapeutic effects and a wide variety of helpful properties for human welfare. Searching information was collected by using electronic databases including Web of Science, Science Direct, Springer, SciFinder, PubMed, Scopus, Medline, Embase, and Google Scholar. This review is, therefore, an effort to give a detailed survey of the literature on its pharmacognosy, phytochemistry, phytochemical, and pharmacological properties of Ficus and its important species. This summary could be beneficial for future research aiming to exploit the therapeutic potential of Ficus and its useful medicinal species.

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Section: P Hytochemical a Nalysis Of F Icus Deltoideamentioning

confidence: 70%

Section: P Harmacological P Roperties Of F Icus Deltoideamentioning

confidence: 99%

An overview of phytochemical and biological activities: Ficus deltoidea Jack and other Ficus spp

Ashraf

Haque²,

Amir

et al. 2021

J Pharm Bioall Sci

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“…Natural extracts have been studies as potential mitigators of prostatic disorders, showing anticancer, antiproliferative, antiapoptotic properties [23,24]. The Jaboticaba (MYRTACEAE Myrciaria jaboticaba (Vell.)…”

Section: Introductionmentioning

confidence: 99%

Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.

Longo

Lamas

Rossetto

et al. 2023

Braz. arch. biol. technol.

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The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and westernblotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ERα); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ERα and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. HIGHLIGHTS• Brazilian berry mitigate the disorder onset in prostate of senile/high-fat mice.• Brazilian berry reduced AR/ERα/IGFR-1 labeling in prostate of senile/high-fat mice.• Brazilian berry preventive effect increases according to the prostatic damages rise.

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“…Plants are self‐possessed with many compounds and they serve as a resource for several effective and influential (bio)active agents and/or drugs in many countries of the world [1, 2]. In many developing countries, conventional medicine is one of the most important healthcare systems [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Investigative evaluation of Cassia absus for antibacterial capacity and biomimetic synthesis of silver nanoparticles

Jehan¹,

Saeed²,

Khan

et al. 2018

IET nanobiotechnol.

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Cassia absus is used for medicinal purposes for a long time all over the world. In this study, the authors report the antimicrobial potential of C. absus extracts obtained with different solvents. The extract(s) obtained with ethyl acetate yielded the best antibacterial effects because of a rich supply of oxalates and alkaloids in it. The same extract was also exploited for reducing Ag + ions (to metallic Ag 0) for the synthesis of nanoparticles. Electron microscopy revealed that the silver nanoparticles were ∼18-25 nm in diameter. The Fourier-transform infrared evaluation pointed towards the fact that flavonoids present in the plant extract were acting as reductants while amino groups were the bound stabilisation agents to the synthesised nanoparticles limiting the diameter to a certain threshold and avoiding aggregation naturally. A comparative antibacterial assay of C. absus versus Ag nanoparticles showed that the nanoparticles as well as organic (ethyl acetate) extract of the plant checked the growth of selected (MDR) superbugs. However, the biosynthesised Ag nanoparticles returned better antibacterial efficacies than ethyl acetate extract.

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Green Tropical Phytoextracts - Promising Anticancer Alternative

Abstract: The anticancer potential of aqueous extracts of tropical plants Ficus deltoidea and

Cited by 5 publications

References 34 publications

An overview of phytochemical and biological activities: Ficus deltoidea Jack and other Ficus spp

An overview of phytochemical and biological activities: Ficus deltoidea Jack and other Ficus spp

Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.

Investigative evaluation of Cassia absus for antibacterial capacity and biomimetic synthesis of silver nanoparticles

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