Diets Rich in Polyunsaturated Fatty Acids With Different Omega-6/Omega-3 Ratio Decrease Liver Content of Saturated Fatty Acids Across Generations of Wistar Rats

Halfen, Simone; Jacometo, Carolina Bespalhok; Mattei, Patrícia; Fenstenseifer, Samanta Regine; Pfeifer, Luiz Francisco Machado; Pino, Francisco Augusto Burkert Del; Santos, Marco Aurélio Ziemann dos; Pereira, Cláudio Martin Pereira de; Schmitt, Eduardo; Corrêa, Márcio Nunes

doi:10.1590/1678-4324-2016150549

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Dietary fat could facilitate 438 S.-O. Park and V. A. Zammit: Glycolipid distribution of n-6 / n-3 in rats adaptation to lipid metabolism in the next generation of rats (Chambers et al, 2016;Halfen et al, 2016). Dietary intake with the ratio of n-6 / n-3 dropped to 8 : 1 or lower from parent generation to the next generation can reduce harmful lipid in the blood, and stimulate growth by activating the metabolism of nutrients (Shin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

In vivo monitoring of hepatic glycolipid distribution of n-6 ∕ n-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

Park

Zammit

2019

Arch. Anim. Breed.

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The metabolic distribution via blood from liver of glycerolipids by omega-6 to omega-3 fatty acid (n-6 / n-3) ratio in monogastric animal nutrition is very important. In vivo monitoring technique using jugular-vein-cannulated rats as a nutritional model for monogastric animal can yield important insights into animal nutrition. This study was conducted to determine the effect of different n-6 / n-3 ratios (71:1, 4:1, 15:1, 30:1) on metabolic distribution of glycerolipids newly synthesized and secreted in the liver of the rats and explore the mechanism involved. Regarding chemnormal14normalCOnormal2 released from oxidation of glycerolipid metabolism, it was the highest (22.5 %) in groups with a n-6 / n-3 ratio of 4:1 (P<0.05). The control group showed the highest total glycerolipid level, followed by the 30:1, 15:1, and 4:1 groups in order (P<0.05). When secreted triacylglycerol level of each group was compared with that of the control group, the 4:1, 15:1, and 30:1 groups were decreased by 36.3 %, 20.9 %, and 13.3 %, respectively (P<0.05). Regarding the distribution of phospholipid against total glycerolipid compared to the control group, the 4:1, 15:1, and 30:1 groups were 1.38, 1.29, and 1.17 times higher, respectively (P<0.05). In the comparison of chemnormal14normalCOnormal2 emission against total glycerolipid compared with the control group, the 4:1, 15:1, and 30:1 groups were 1.61, 1.52, and 1.29 times higher, respectively (P<0.05). These results demonstrate that a dietary n-6 / n-3 fatty acid ratio of 4:1 could significantly decrease harmful lipid levels in the blood by controlling the mechanism of metabolic distribution via blood from triglyceride and phospholipid newly synthesized in the liver of cannulated rat.

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Section: Introductionmentioning

confidence: 99%

In vivo monitoring of hepatic glycolipid distribution of n-6 ∕ n-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

Park

Zammit

2019

Arch. Anim. Breed.

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“…In the present study, the 1:1 and 5:1 groups had lower serum LPL levels than those in the 20:1, Lard, and NC groups, and the 1:1 and Lard groups had lower serum FFA concentrations compared with those in the 20:1 and NC groups. Halfen et al (2016) found that a low n-6/n-3 PUFA diet was more effective in reducing blood TG and FFA levels in Wistar rats compared with those of high n-6/n-3 PUFA diets. Chang et al (2014) reported that replacing SFAs in a high-fat diet with n-3 PUFAs reduced aortic LPL levels in LDLR -/mice.…”

Section: Discussionmentioning

confidence: 90%

Effects of blended oils with different n-6/n-3 polyunsaturated fatty acid ratios on high-fat diet-induced metabolic disorders and hepatic steatosis in rats

Yang

Song

et al. 2022

Food Sci. Technol

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This study investigated the effects of blended oils with different n-6/n-3 polyunsaturated fatty acid (PUFA) ratios on the metabolic disorders and hepatic steatosis in high-fat diet-fed rats. The 1:1 group had significantly lower serum low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), and lipoprotein lipase (LPL) levels than those of the Lard group. The 5:1 group had significantly lower serum LDL-C, LPL, and adiponectin (ADP) than those in the Lard group. Serum LDL-C, angiotensin II (Ang II), endothelin-1, LPL and ADP levels in the 1:1 and 5:1 groups were significantly lower than those in the normal control group. The 5:1 group had significantly lower serum ADP, Ang II, LPL and resistin levels than those in the 20:1 group. The 20:1 group had significantly higher serum TC, LDL-C, HDL-C, nitric oxide (NO), 3-nitrotyrosine, free fatty acid and LPL levels than those in the 1:1 ratio group. Blended oils with a low n-6/n-3 PUFA ratio improved metabolic disorders and hepatic steatosis by regulating lipid metabolism, adipokines, endothelial cell function, and liver lipid metabolism. Conversely, a high n-6/n-3 PUFA ratio had adverse effects on metabolic profiles in high-fat diet-fed rats.

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Elaboration and quality control of the piracui from trahira (Hoplias malabaricus) during storage

Neta

Almeida

Grisi

et al. 2021

International Journal of Gastronomy and Food Science

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Diets Rich in Polyunsaturated Fatty Acids With Different Omega-6/Omega-3 Ratio Decrease Liver Content of Saturated Fatty Acids Across Generations of Wistar Rats

Abstract: Our study evaluated how the consumption of diets with low or high

Cited by 4 publications

References 29 publications

In vivo monitoring of hepatic glycolipid distribution of <i>n</i>-6 ∕ <i>n</i>-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

In vivo monitoring of hepatic glycolipid distribution of <i>n</i>-6 ∕ <i>n</i>-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

Effects of blended oils with different n-6/n-3 polyunsaturated fatty acid ratios on high-fat diet-induced metabolic disorders and hepatic steatosis in rats

Elaboration and quality control of the piracui from trahira (Hoplias malabaricus) during storage

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Diets Rich in Polyunsaturated Fatty Acids With Different Omega-6/Omega-3 Ratio Decrease Liver Content of Saturated Fatty Acids Across Generations of Wistar Rats

Abstract: Our study evaluated how the consumption of diets with low or high

Cited by 4 publications

References 29 publications

In vivo monitoring of hepatic glycolipid distribution of &lt;i&gt;n&lt;/i&gt;-6 ∕ &lt;i&gt;n&lt;/i&gt;-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

In vivo monitoring of hepatic glycolipid distribution of &lt;i&gt;n&lt;/i&gt;-6 ∕ &lt;i&gt;n&lt;/i&gt;-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

Effects of blended oils with different n-6/n-3 polyunsaturated fatty acid ratios on high-fat diet-induced metabolic disorders and hepatic steatosis in rats

Elaboration and quality control of the piracui from trahira (Hoplias malabaricus) during storage

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In vivo monitoring of hepatic glycolipid distribution of <i>n</i>-6 ∕ <i>n</i>-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

In vivo monitoring of hepatic glycolipid distribution of <i>n</i>-6 ∕ <i>n</i>-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal