Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease

Fallah, Soudabeh; Fadaei, Reza; Ahmadi, Reza; Azardokht, Tabatabei; Seifi, Morteza

doi:10.1590/1678-4324-2016150509

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Several studies reported that H. pylori may cause symptoms of extra-gastrointestinal diseases such as peptic ulcer [11], idiopathic thrombocytopaenic purpura [14], iron deficiency anaemia [15], hepatic and cardiovascular symptoms [16,17], and biliary duct diseases [24]. Therefore, it can be concluded that this bacterium can affect the development and progress of some diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Today, the role of H. pylori infection is reported in many diseases, including idiopathic thrombocytopenic purpura [14], iron deficiency anaemia [15], and hepatic and cardiovascular symptoms and biliary tract disease [16,17]. Moreover, in some studies, the role of H. pylori in cirrhosis [18][19][20][21], hepatic encephalopathy [22,23], primary biliary cirrhosis [24], and bleeding oesophageal varices [25] is emphasised.…”

Section: Introductionmentioning

confidence: 99%

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Association between Helicobacter pylori infection and cirrhosis in children

Zahmatkeshan¹,

Matani²,

Asadian³

2019

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Introduction: Liver cirrhosis is often accompanied by fibrosis, loss of liver function, and liver cancer. Identification of the factors associated with this disease has always been a goal because they can be effective in its treatment. Several reports showed that Helicobacter pylori (H. pylori) can cause multiple gastrointestinal complications. Aim of the research: To investigate the association between H. pylori infection and liver cirrhosis in children. Material and methods: In this case-control study, 60 children under the age of 18 years with liver cirrhosis participated as the cases, and 236 healthy children were included as controls. For evaluation of the H. pylori antigen (Ag) of the samples, fresh stool samples were prepared. Results: Thirty-two (53.3%) samples in the cases, and 46 (19.5%) samples in controls had positive H. pylori Ag test. The results showed that the two groups had significant differences in terms of infection by H. pylori stool antigen; the presence of this Ag in the case samples was more than in the controls (p < 0.001). Conclusions: That the rate of H. pylori infection in children with cirrhosis was significantly higher than among healthy children. This result can indicate the effect of this bacterium on the incidence and development of liver cirrhosis. Streszczenie Wprowadzenie: Zwłóknienie, utrata funkcji wątroby, a także rak wątroby często towarzyszą marskości wątroby. Zawsze określano czynniki związane z marskością, ponieważ może się to okazać skutecznym podejściem w leczeniu. Wyniki szeregu badań wykazały, że Helicobacter pylori (H. pylori) może być przyczyną licznych powikłań żołądkowo-jelitowych. Cel pracy: Zbadanie związku między zakażeniem H. pylori i marskością wątroby u dzieci. Materiał i metody: W badaniu kliniczno-kontrolnym wzięło udział 60 dzieci w wieku do 18 lat (grupa badana) oraz 236 zdrowych dzieci (grupa kontrolna). Wykonano badanie próbek kału na obecność antygenu (Ag) H. pylori. Wyniki: Pozytywne wyniki na obecność antygenu H. pylori uzyskano w przypadku 32 (53,3%) próbek pochodzących od chorych dzieci i 46 (19,5%) próbek od grupy kontrolnej. Na podstawie wyników stwierdzono różnice między tymi grupami pod względem zakażenia H. pylori; wykazano większą częstość występowania antygenu w grupie badanej w porównaniu z grupą kontrolną (p < 0,001). Wnioski: Częstość występowania zakażenia H. pylori u dzieci chorych na marskość była istotnie większa niż w grupie zdrowych dzieci. Wynik ten wskazuje na wpływ bakterii na występowanie i rozwój marskości wątroby.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and cirrhosis in children

Zahmatkeshan¹,

Matani²,

Asadian³

2019

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“…In 1994, the International Agency for Research on Cancer (IARC) categorized H. pylori as a class I carcinogen and reported it in 75% of patients with MALT lymphoma and in 60% of those with an increasing risk of gastric cancer (Malfertheiner et al., 2017 ; Morgner et al., 2000 ). Also, H. pylori infection could be related to some important diseases in humans such as the reduction of the ferritin and iron levels in patients with coronary artery disease and changes in lipid profiles and inflammatory factors, such as pre‐eclampsia as a result of impairing the placental development, and glucose homeostasis in patients with type 2 diabetes (Bonfigl, 2016 ; Di Simone et al., 2017 ; Fallah et al., 2016 ). Furthermore, the infection is directly related to the metabolic syndromes such as high values of triglycerides, body mass index and systolic blood pressure and low HDL (Upala et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

An exploratory study on the presence of Helicobacter heilmannii and Helicobacter billis in the feces of companion dogs

Khader

Borujeni

Bakhtiari

2022

Veterinary Medicine & Sci

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Background: Companion animals like dogs play an important role in the lives of many people and are often considered to be members of families, but definitely, any contact with them poses an inherent risk of transmitting zoonotic pathogens. One of these pathogens is the genus Helicobacter which is linked to many disorders in human and animal. Objectives:The aim of this study was to investigate the presence of some zoonotic species of genus Helicobacter in companion dogs.Results: Through culturing in a special medium, nine samples (9%) were detected as infected (two pure and seven mixed culture). Based on multiplex-PCR, 13 samples (13%) were infected by Helicobacter spp. although none of them were infected by H. pylori. Species-specific PCR indicated that 38.5% or 5/13 of the samples were infected with H. heilmannii, while 15.45% or 2/13 of the samples were infected by H. billis. Multivariate logistic regression analysis showed that the age factor had a significant effect on Helicobacter spp. infection (odds ratio [OR] = 2.42, p = 0.01). Conclusion:This study revealed the negligible faecal transmission of H. pylori. Moreover, due to the detection of H. Heilmannii and H. billis in feces and their association with human gastric diseases, dog owners should be educated about the risks and transmission modes of zoonotic bacterial infections of dogs.

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Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale

Talepoor

Fouladseresht

Khosropanah

et al. 2020

EMIDDT

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Background and Objective: Atherosclerosis, a chronic and progressive inflammatory disease, is triggered by the activation of endothelial cells followed by infiltration of innate and adaptive immune cells including monocytes and T cells in arterial walls. Major populations of T cells found in human atherosclerotic lesions are antigen-specific activated CD4+ effectors and/or memory T cells from Th1, Th17, Th2 and Treg subsets. In this review, we will discuss the significance of T cell orchestrated immune inflammation in the development and progression of atherosclerosis. Discussion: Pathogen/oxidative stress/lipid induced primary endothelial wound cannot develop to a full-blown atherosclerotic lesion in the absence of chronically induced inflammation. While the primary inflammatory response might be viewed as a lone innate response, the persistence of such a profound response over time must be (and is) associated with diverse local and systemic T cell responses. The interplay between T cells and innate cells contributes to a phenomenon called immuneinflammation and has an impact on the progression and outcome of the lesion. In recent years immuneinflammation, an old term, has had a comeback in connecting the puzzle pieces of chronic inflammatory diseases. Conclusion: Taking one-step back and looking from afar at the players of immune-inflammation may help us provide a broader perspective of these complicated interactions. This may lead to the identification of new drug targets and the development of new therapies as well as preventative measures.

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Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease

Abstract: This work aimed to determine whether seropositivity to

Cited by 6 publications

References 18 publications

Association between Helicobacter pylori infection and cirrhosis in children

Association between Helicobacter pylori infection and cirrhosis in children

An exploratory study on the presence of Helicobacter heilmannii and Helicobacter billis in the feces of companion dogs

Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale

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