Papillary Adenocarcinoma of the descending colon in a dog: case report

Abstract

The aim of this report was to describe the clinical findings and therapeutic management of a case of papillary adenocarcinoma of the descending colon in a Beagle. The patient presented soft stools, haematochezia, tenesmus, and dyschezia. Clinical examination revealed alterations on the ultrasonographic features of the descending colon suggestive of colitis and neoplasia. Following local mass resection, histopathology analysis revealed mild lymphoplasmocytic enteritis and papillary adenocarcinoma of the colon. Enterectomy for tumoral resection and biopsy of locoregional lymph nodes were carried out. Subsequent to the surgical procedure, it was possible to confirm the previous diagnosis and the tumor was classified as intestinal intraluminal papillary adenocarcinoma, with incomplete surgical margins. Adjuvant chemotherapy was performed using carboplatin, cyclophosphamide, and piroxicam, leading to remission of clinical signs and absence of any clinical or imaging alterations compatible with the patient's previous clinical condition. Palavras-chave: canino, neoplasia intestinal, oncologia

Infiltrative Rectal Adenocarcinoma in a Dog

“…Microscopy featured a chronic ulcerative colitis frame; according to the National Cancer Institute [9], such alteration represents one of the main risk factors for colon rectal cancer in humans. Other studies conducted with dogs also showed colitis associated with adenocarcinoma, although in the descending colon [5]. Therefore, the chronic intestinal inflammatory process can also be a risk factor for canine species.…”

“…The histopathological findings comply with others described by Damasceno et al [3], who evidenced growing infiltrative neoplasm formed by atypical cells of tubular arrangement. However, the aforementioned authors found cells with tubopapillary disposition, but Ferreira et al [5] detected the papillary sub-type in the descending colon in a canine specimen belonging to the Beagle breed. It highlights the importance of the uncommon occurrence of the type of tubular neoplasms in the large intestine.…”

“…The digestive tract in dogs can present a whole variety of neoplasms [16,19,21]; however, such neoplasms have low incidence in this animal species [6], they represent from 2% [16] to 5% of the number of described neoplasms [21]. Adenocarcinoma is the most prevalent intestinal tumor [4,5,10,13,16,20] it mainly occurs in the large intestine [5,6,21], mainly in the rectal segment [3,10,13,19].…”

“…Histologically speaking, neoplasm cells can present solid [7], tubular [7,13,10], papillary [5] or tubopapillary [3,7] arrangement. Moreover, it is possible observing amorphous extra-cellular material, which is characteristic of mucin in the tubular lumen [3,10,13].…”

“…Moreover, it is possible observing amorphous extra-cellular material, which is characteristic of mucin in the tubular lumen [3,10,13]. Disorders such as tenesmus, diarrhea, dyskinesia [4,5,14,20], hematochezia [4,5], mane [3,4] and protrusion of the anus may occur. Other clinical signs such as weight loss, anorexia and apathy can be seen in the late stages of neoplastic growth [14].…”