Biocerâmica de fosfato de cálcio nanoestruturada micro-macroporosa em grânulos de absorção rápida no preenchimento de defeito crítico em rádio de coelhos (Oryctolagus cuniculus)

Castro, J.A.; Aristizabal, O.L.P.; Alves, Endrigo Gabellini Leonel; Louzada, Mário Jefferson Quirino; Tôrres, R.C.S.; Vilória, Marlene Isabel Vargas; Rezende, C.M.F.

doi:10.1590/1678-4162-9242

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…10 When assessing the effect of the association between HA / TCP-β as a bone substitute in guinea pigs with induced osteopenia, it was found that the animals treated with this association showed better results in repairing bone defects, in addition to a more organized neoformation than the group control. 17 Another study compared the histological aspects to the biocompatibility of HA, TCP-β and the association of the two (HA / TCP-β) in the form of particles implanted in subcutaneous tissue of guinea pigs. It was observed that the group treated with TCP-β particles showed a large amount of fibroblasts and blood vessels, in addition to an exacerbated inflammatory response, with presence of macrophages and multinucleated giant cells in the first 60 days.…”

Section: Discussionmentioning

confidence: 99%

Biomedical Applications of Calcium Phosphate Ceramics as Biomaterials

Bezerra¹,

Silva²,

Bezerra³

et al. 2020

JYP

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The application of ceramics as bone substitutes is mainly due to their bioactivity property, presenting an ability to adhere to adjacent bone tissues. In the last decades the number of researches with bioactive ceramics in bone grafts has grown. The objective of the present study was to perform a literature review of the application of calcium phosphate ceramics in the biomedical fields. For this present study, 21 articles indexed indatabases, mainly through in PubMed and LILACS were selected and published between the years 2004 to 2019. Calcium phosphates are examples of bioceramics and are part of a group of combinations that constitute the natural structure of bones humans and teeth. The main reasons for calcium phosphate biomaterials standing out for bone replacement are their facility of use and biocompatibility. Current research indicates that the association of hydroxyapatite (HA) with tricalcium phosphate β (TCP-β) promotes better results regarding bone neoformation, showing promising results in the biomedical and biomaterials area, in the replacement of bone tissues. Synthetic bioactive ceramics have several applications and efficacy in the biomedical fields. HA and TCP-β have several properties scientifically demonstrated, the association of both being the result of the search for new materials and their improvement.

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Section: Discussionmentioning

confidence: 99%

Biomedical Applications of Calcium Phosphate Ceramics as Biomaterials

Bezerra¹,

Silva²,

Bezerra³

et al. 2020

JYP

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Synthesis and characterization of silver-incorporated calcium phosphate antibacterial nanocomposites for mask filtration material

Zhao

Jiang

et al. 2018

Composites Part B: Engineering

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The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

et al. 2020

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Bioceramic scaffolds are appealing for alveolar bone regeneration, because they are emerging as promising alternatives to autogenous and heterogenous bone grafts. The aim of this systematic review is to answer to the focal question: in critical-sized bone defects in experimental animal models, does the use of a bioceramic scaffolds improve new bone formation, compared with leaving the empty defect without grafting materials or using autogenous bone or deproteinized bovine-derived bone substitutes? Electronic databases were searched using specific search terms. A hand search was also undertaken. Only randomized and controlled studies in the English language, published in peer-reviewed journals between 2013 and 2018, using critical-sized bone defect models in non-medically compromised animals, were considered. Risk of bias assessment was performed using the SYRCLE tool. A meta-analysis was planned to synthesize the evidence, if possible. Thirteen studies reporting on small animal models (six studies on rats and seven on rabbits) were included. The calvarial bone defect was the most common experimental site. The empty defect was used as the only control in all studies except one. In all studies the bioceramic materials demonstrated a trend for better outcomes compared to an empty control. Due to heterogeneity in protocols and outcomes among the included studies, no meta-analysis could be performed. Bioceramics can be considered promising grafting materials, though further evidence is needed.

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Biocerâmica de fosfato de cálcio nanoestruturada micro-macroporosa em grânulos de absorção rápida no preenchimento de defeito crítico em rádio de coelhos (Oryctolagus cuniculus)

Cited by 3 publications

References 11 publications

Biomedical Applications of Calcium Phosphate Ceramics as Biomaterials

Biomedical Applications of Calcium Phosphate Ceramics as Biomaterials

Synthesis and characterization of silver-incorporated calcium phosphate antibacterial nanocomposites for mask filtration material

The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

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