Utilização de sal mineral rico em molibdênio na prevenção da intoxicação cúprica acumulativa em ovinos - microminerais hepáticos

Abstract

 RESUMOEste estudo avaliou a capacidade de um sal mineral rico em molibdênio (Mo) em prevenir a intoxicação cúprica acumulativa (ICA), mediante a análise das variáveis clínicas e dos teores de cobre (Cu) e Mo hepático. Foram utilizados 25 ovinos cruzados da raça Ile-de-France, aleatoriamente distribuídos igualmente em cinco grupos, em que o grupo 1 recebia dieta contendo 80% de volumoso e 20% de concentrado, os grupos 2 e 3 recebiam 50% de volumoso e 50% de concentrado, e os grupos 4 e 5 recebiam a mesma dieta dos grupos 2 e 3, com a adição diária de 150mg de sulfato de Cu. Os grupos 1, 3 e 5 recebiam sal mineral contendo 300ppm de Mo. Foram realizadas três biópsias hepáticas para determinação de Cu, Mo e Zn. Três ovinos do grupo 4 e um do grupo 5 manifestaram ICA. Não houve diferença na frequência de mortalidade entre os grupos (P=0,56). Os teores de Cu hepático nos ovinos com ICA (2450ppm) foram superiores aos que não intoxicaram (1518ppm). Quanto maior a ingestão de Mo na dieta, menor foi o acúmulo de Cu hepático ao término do experimento (r = -0,72).Palavras-chave: carneiro, cobre, antagonistas, fígado ABSTRACT The aim of this project is to evaluate the capacity of a molybdenum-rich mineral salt in the prevention of cumulative cooper poisoning (CCP) in

Seasonality Effects on the Mineral Profile of Goats Farmed in the Semiarid Region of Brazil

“…Liver Mo concentration remained within the normal range (2 to 4 ppm) as reported by Suttle [ 6 ] but below the levels found in Pernambuco (6.5 ppm) by Marques et al [ 21 ]. In general, the levels were similar to the data reported for sheep in other studies [ 26 , 31 ]. The observed difference ( p ≤ 0.05) in both serum and liver Mo concentrations between the treated and control groups showed the positive effect of Mo supplementation.…”

“…Liver Cu levels in both groups and during all seasonal periods were below the levels reported by several other studies, wherein values of between 150 and 328 ppm were observed [ 16 , 20 , 26 ]. However, there was an important difference between the treated and control animals; the Cu levels in control animals were 34% below those of the treatment animals in the same periods.…”

“…Serum Mo concentrations varied between 0.11 ± 0.04 and 0.71 ± 0.41 µmol/L in this study. Studies on goats, and mainly on sheep, have reported serum levels between 0.28 ± 0.11 and 0.8 ± 0.19 µmol/L [ 20 , 26 , 30 ] according to the content of this element in the diet. Serum levels reported by Marques et al [ 21 ] in goats in the northeast (0.28 ± 0.11 μmol/L) were much higher than those found in the two seasonal periods in the control group (0.11 ± 0.04 μmol/L at the end of dry season and 0.15 ± 0.09 μmol/L in the middle of the rainy season).…”

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

“…Primary CCP may be associated with ingestion of copper (Cu)-contaminated feedstuff [7], industrial waste, feeding broiler or pig manure [8], or the accidental use of mineral supplements containing high Cu levels that are formulated for other species [9,10]. Secondary CCP is also very common and appears to be associated with interactions in the gut with other essential trace elements such as sulphur (S), molybdenum (Mo), and iron (Fe) when these are not balanced in the diet [11,12]. As a result of these interactions, minimum requirements and maximum allowances of Cu are dependent on dietary Cu concentrations and are also difficult to establish.…”

“…In areas where there is a high risk of CCP, Cu loading is mainly prevented by modifying dietary concentrations of Cu antagonists. Dietary supplementation with Mo and S has been useful in preventing the disease [12,21]. However, use of this measure in the field may be limited by the risk of inducing a Cu deficiency state or sulphur intoxication.…”