2016
DOI: 10.1590/1678-4162-8561
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Papain is a proteolytic enzyme removed from the leaves of green papaya and/or latex. This enzyme is widely known as a medicinal fruit used extensively in human medicine for the treatment of wounds of various etiologies. However, studies and reports in veterinary medicine are scarce. Another herbal drug widely used in wound healing is Sunflower oil (Helianthus annus). It has inflammatory and antimicrobial properties which stimulate the local neovascularization, promoting tissue granulation, cell migration, fibr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2021
2021
2022
2022

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 3 publications
(4 reference statements)
0
2
0
Order By: Relevance
“…While effectively degrading necrotic tissues, papain does not affect healthy tissues due to its inactivation by α1-antitrypsin, which makes papain an attractive wound healing agent. Thus, in several studies papain-containing gels were reported as effective agents for venous ulcers healing, which can be safely used in granulation tissue [ 54 , 55 , 56 ].…”
Section: Discussionmentioning
confidence: 99%
“…While effectively degrading necrotic tissues, papain does not affect healthy tissues due to its inactivation by α1-antitrypsin, which makes papain an attractive wound healing agent. Thus, in several studies papain-containing gels were reported as effective agents for venous ulcers healing, which can be safely used in granulation tissue [ 54 , 55 , 56 ].…”
Section: Discussionmentioning
confidence: 99%
“…The cosmetic, medical and pharmaceutical segments have started to use papain to improve product quality due to the increase in the use of bio-derived and eco-friendly ingredients [6,7]. Papain has been applied as a debridement agent of wounds [8][9][10], exfoliation agent [11,12], depilatory agent [13] and transdermal drug permeation enhancer [14], for example. The chemical stability of papain, which may decrease depending on the storage and presence of other ingredients in the formulation, is the most evaluated effect in terms of skin application, principally related to the complexation of the enzyme with polymers [2,13,[15][16][17].…”
Section: Introductionmentioning
confidence: 99%