Biomarcadores inflamatórios e de estresse oxidativo em cadelas submetidas à ovário-histerectomia videoassistida ou convencional

Dalmolin, Fabíola; Lhamas, Cibele Lima; Filho, Saulo Tadeu Lemos Pinto; Feranti, João Pedro Scussel; Poerschke, A.; Beck, Ruy Carlos Ruver; Abdalla, Fátima Husein; Andrade, Cínthia Melazzo de; Brun, Maurício Veloso

doi:10.1590/1678-4162-8276

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…This similarity is attributed to the less invasiveness of the video-assisted procedures, which promote less somatic stimulation since both the surgical incision as the tissue damage of the skin and musculature are significantly smaller when compared to the celiotomy. This data corroborates with comparative studies between conventional and video-assisted OVHs using two-port, concluding that video surgery promotes lesser pain and surgical stress (CASE et al, 2015;DALMOLIN et al, 2016).…”

Section: Discussionsupporting

confidence: 83%

Use of bupivacaine infiltrative local block in bitches submitted to ovariohysterectomy by celiotomy or video-assisted surgery by two-portals access

Martins¹,

Teixeira²,

Linhares³

et al. 2022

Rev Agr Acad

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This randomized blinded study objected to investigate a local anesthesia (0,5% bupivacaine) in the surgical incision site in dogs underwent to ovariohysterectomy by celiotomy or video-assisted by two-portal. Twenty-eight healthy adults were selected. Dogs were divided into celiotomy control group, celiotomy blocking group (BC), video-assisted control group and blocking video-assisted group (BV). In the BC and BV, bupivacaine was administered SC in the incision line or port sites. Control groups received NaCl 0,9% at the same sites. Three evaluators blinded evaluated postoperative pain, using Melbourne Pain Scale and visual analog scale. The anesthetic infiltrative blockade used was efficient in promoting postoperative comfort in both celiotomy and video assisted OVH.

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Section: Discussionsupporting

confidence: 83%

Use of bupivacaine infiltrative local block in bitches submitted to ovariohysterectomy by celiotomy or video-assisted surgery by two-portals access

Martins¹,

Teixeira²,

Linhares³

et al. 2022

Rev Agr Acad

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“…The higher levels of catalase enzyme (CAT) in treatments using S . pseudoquina extract (LE5 and LE10), on day seven of the experiment, show the antioxidant effect of this extract, since CAT is part of the cell antioxidant defense and catalyzes the decomposition of Hydrogen peroxide (H 2 O 2 ) [ 15 , 69 ]. The topic treatment with Phaleria macrocarpa extract provided similar results, namely, increased SOD and CAT enzyme activity, reduced MDA levels and tissue damage, and accelerated wound healing processes [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

“…The continuous production of ROS causes oxidative stress, which leads to degenerative changes and increases tissue damage, thus forming a fragile and scarcely resistant scar [ 13 ]. Detoxification of cells by the activation of antioxidant defense systems, especially superoxide dismutase (SOD) and catalase (CAT) enzymes, guarantees a harmonious process of tissue repair [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Strychnos pseudoquina modulates the morphological reorganization of the scar tissue of second intention cutaneous wounds in rats

et al. 2018

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Natural substances are used in folk medicines to treat injuries. Strychnos pseudoquina has scarring, antipyretic, and antimalarial actions. The present study aimed to analyze the effect of S. pseudoquina on cutaneous wound healing in rats. The S. pseudoquina extract was submitted to phytochemical prospection. The levels of flavonoids and total phenolic compounds in the extract were 50.7 mg/g and 2.59 mg/g, respectively. Thirty Wistar rats were individualized in cages with food and water ad libitum (registration no. 730/2014). After anesthesia, three circular wounds (12mm diameter) were made in the animals, which were randomly separated into five treatments: Sal, saline; VO, ointment vehicles (lanolin and Vaseline); SS, positive control (silver sulfadiazine 1%); LE 5, freeze-dried extract 5%; and LE 10, lyophilized extract 10%. The animals were treated with the ointment daily for 21 days. Every seven days, the area and the rate of wound contraction were evaluated. Tissue samples were removed for histopathological analysis of the number of mast cells, elastic and collagen fibers, and biochemical analyses, quantification of malondialdehyde (MDA), carbonylated proteins (PCN), superoxide dismutase (SOD), catalase (CAT), transforming growth factor β (TGF-β), Interleukin 10 (IL-10) and tumor necrosis factor (TNF). The number of mast cells, collagen and elastic fibers in the rat wounds were higher in the treatments with the plant. The extract also stimulated the activity of antioxidant enzymes, particularly SOD, presenting high levels, and maintained low levels of PCN. The TGF-β and IL-10 concentration was higher in the LE5 and LE10 treatment of the extract than in the Sal, OV and SS treatments on day 7. The ointment based on S. pseudoquina closed the wound faster and accelerated wound healing in animals.

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Effects of a diet enriched with eicosapentaenoic, docosahexaenoic and glutamine on cytokines as immunological markers for systemic inflammation in bitches before and after ovariohysterectomy

Porsani

Bonder

Teixeira

et al. 2019

Animal Physiology Nutrition

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The post‐operative period can generate immunological stress and can be modulated through supplementation with the omega‐3 series of polyunsaturated fatty acids. This study aimed to evaluate the effects of diets enriched with high doses of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids and glutamine on inflammatory mediators in dogs before and after ovariohysterectomy (OVH). Twelve female dogs were divided into two groups: group A was fed a commercial diet without the addition of EPA and DHA, and group B was fed an experimental diet enriched with EPA and DHA (0.2 g/100 kcal). Experimental diet intake initiated 21 days before surgery and continued until 30 days after OVH. Parameters measured were serum cytokines (TNF‐α, IL‐6 and IL‐10), C‐reactive protein (CRP), IGF‐1, lymphoproliferation and body composition before and after surgery. Statistical analyses were performed with SAS software considering the effects of age and diet and their interactions, and means were compared by the Tukey test. There was no difference between groups in body weight (p = .682), lean mass (p = .101) and body fat (p = .103). There were no group differences in serum concentrations of TNF‐α, IL‐6, IL‐10, IGF‐1, CRP and the percentage of lymphocyte proliferation. However, a time effect for TNF‐α was observed (p < .001), in which T0P (10 days after the surgical procedure) presented lower values of this cytokine when compared to the other evaluation time points; and interaction effects between group and time were observed for serum concentrations of IL‐6 (p < .001) and IL‐10 (p = .002). OVH procedure was not considered invasive enough to increase inflammatory cytokines after 30 days of surgery, as well as the dosage of the EPA and DHA used before and after the surgery did not modulate the inflammatory markers.

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Biomarcadores inflamatórios e de estresse oxidativo em cadelas submetidas à ovário-histerectomia videoassistida ou convencional

Abstract: Biomarcadores inflamatórios e de estresse oxidativo em cadelas submetidas à ovário-histerectomia videoassistida ou convencional

Cited by 3 publications

References 19 publications

Use of bupivacaine infiltrative local block in bitches submitted to ovariohysterectomy by celiotomy or video-assisted surgery by two-portals access

Use of bupivacaine infiltrative local block in bitches submitted to ovariohysterectomy by celiotomy or video-assisted surgery by two-portals access

Strychnos pseudoquina modulates the morphological reorganization of the scar tissue of second intention cutaneous wounds in rats

Effects of a diet enriched with eicosapentaenoic, docosahexaenoic and glutamine on cytokines as immunological markers for systemic inflammation in bitches before and after ovariohysterectomy

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