Regulatory T cells in dogs with multicentric lymphoma: peripheral blood quantification at diagnosis and after initial stage chemotherapy

Combination Chemotherapy with Firocoxib Induces Reduction of Regulatory T Cells in Dogs with Multicentric B Cell Lymphoma

“…Tominaga et al (2010) also observed that dogs with oral cavity melanoma showed greater percentage of Treg cells in peripheral blood than control animals. More recently, Munhoz et al (2016) described an increase in Treg cells of dogs with multicentric lymphomas when compared to controls.…”

“…In the present study, a reduction in circulating Treg cells was observed in both treatment groups. In addition to the classic anti-tumoral effects of anti-neoplastic agents, it is known that doxorubicin and cyclophosphamide can induce a reduction in Treg cells in dogs with different neoplasias, including lymphomas (Mitchell et al, 2012;Munhoz et al, 2016). During treatment, the reduction in the percentage of Treg cells observed in dogs treated with firocoxib was slower than in those treated with prednisone, suggesting that the later promotes a more immediate response while the former a more delayed one.…”