Dermatosparaxis in two White Doper lambs in Brazil: case report

Abstract

Dermatosparaxis is a genetic disease that affects collagen maturation. This disease is characterized by marked impairment of the resistance of collagen fibers that leads to skin fragility, and it may affect several species. This is the first report of dermatosparaxis in sheep in Brazil. Clinically, two White Dorper lambs had multiple skin lacerations in the neck, dorsum and limbs. Transmission microscopy demonstrated irregular collagen fibers arranged in hieroglyphic shape and scanning electron microscopy demonstrated thin collagen fibrils that were not arranged in bundles as observed in the normal dermis. These findings are consistent with the diagnosis of dermatosparaxis.Keywords: sheep, dermatosparaxis, collagen, skin RESUMO A dermatosparaxis é uma doença genética que afeta a maturação do colágeno. Essa doença é caracterizada por redução acentuada da resistência das fibras colágenas que leva à fragilidade da pele. Esse é o primeiro relato de dermatosparaxis em ovinos no

Prevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermatosparaxis in White Dorper sheep in Brazil

“…Dermatosparaxis has previously been described in many species, including cattle (Kawaguchi et al 1988), horses (White et al 2004), dogs (Paciello et al 2003), cats (Sequeira et al 1999), and rabbits (Sinke et al 1997). The disorder occurs predominately in White Dorper sheep and has been reported in South Africa (van Halderen & Green 1988), Australia (Aggs 2007), Spain (Sucupira et al 2009), New Zealand (Vaatstra et al 2011), the United States (Grant and Patton 2012) and Brazil (Andrade et al 2014, Silva et al 2015. However, other breeds may also be affected (Fjølstad & Helle 1974, Ramshaw et al 1983, Van Weeren-Keverling & Koeman 1986, Monteagudo et al 2015.…”