2020
DOI: 10.1590/1678-4162-11539
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Abstract: The elastic cartilage is composed by chondroblasts and chondrocytes, extracellular matrix and surrounded by perichondrium. It has a low regeneration capacity and is a challenge in surgical repair. One of obstacles in engineering a structurally sound and long-lasting tissue is selecting the most appropriate scaffold material. One of the techniques for obtaining biomaterials from animal tissues is the decellularization that decreases antigenicity. In this work, alkaline solution was used in bovine ear elastic ca… Show more

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Cited by 2 publications
(2 citation statements)
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“…Advances in the area of tissue engineering have enabled the development and improvement of new biomaterials to provide the recovery of the functional and morphological capacity of the injured tissues. In the search for improving the characteristics of scaffolding in recent years, alternatives have been studied with greater intensity [ 14 , 15 ]. Therefore, this experimental protocol investigated the effects of elastin and collagen matrices on cranial defects in rats and, according to the results, it is possible to state that the collagen matrix was more effective in the regenerative process.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Advances in the area of tissue engineering have enabled the development and improvement of new biomaterials to provide the recovery of the functional and morphological capacity of the injured tissues. In the search for improving the characteristics of scaffolding in recent years, alternatives have been studied with greater intensity [ 14 , 15 ]. Therefore, this experimental protocol investigated the effects of elastin and collagen matrices on cranial defects in rats and, according to the results, it is possible to state that the collagen matrix was more effective in the regenerative process.…”
Section: Discussionmentioning
confidence: 99%
“…The manufacturing process of elastin and collagen matrices and their characterizations have been described in greater detail in previously published studies [ 7 , 19 , 27 , 40 , 41 , 42 ]. The elastin matrices used were prepared by the Biochemistry and Biomaterials Group of the São Carlos Institute of Chemistry (University of São Paulo—USP, Brazil) by adapting the methodology used to obtain collagen [ 7 , 8 , 14 ]. In summary, the cartilages were treated with an alkaline solution, a mechanism known as hydrolysis, with salts sulfates and chlorides and alkaline earth alkali metal hydroxides at 37 °C for 24 h (E24/37).…”
Section: Methodsmentioning
confidence: 99%