The aim of this study was to determine zootechnical and health performance of Girolando calves born with high or low birth weight, and compare metabolic parameters between groups. The study was carried out on a commercial dairy farm located in Passos, Minas Gerais, Brazil. In this sense, a hundred Girolando calves were divided into 2 groups: Control, which consisted of calves that were born weighing ≤ 35 kg; and HBW, calves that were born weighing > 35 kg. Calves were monitored for zootechnical parameters; epidemiological indexes such as morbidity, mortality, recurrence of diarrhea, pneumonia; as well as serum concentrations of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, cholesterol, triglycerides, paraoxonase1, albumin, urea and globulin). Calves from the HBW group had a higher mortality rate as well as a tendency to more cases of pneumonia, but no effect on zootechnical performance was seen. The reasons for the differences in mortality need to be clarified since our study found no changes in biochemical parameters between the groups. The results allow us to conclude that Girolando calves from in vitro fertilization that are born heavier have a greater chance of clinical complications and a higher mortality rate, but the birth weight does not influence the zootechnical performance.