Extranodal lymphoma in a bush dog (Speothos venaticus) - case report

Abstract

A captive 7-year-old male bush dog (Speothos venaticus) was diagnosed with lymphoma affecting the kidneys, adrenal glands, liver, and spleen. The animal developed renal failure and was euthanized due to poor prognosis. Grossly, both kidneys were enlarged with multiple nodules. Histologically, the neoplasm was an infiltrative and poorly demarcated round cell tumor. Two morphologically distinct cell populations were observed, smaller cells with a lymphocytic morphology, and another population of larger and pleomorphic cells. Most of the smaller cell population, approximately 40% of the population within the neoplasm, were CD3 positive. Neoplastic cells were CD45, CD11d, and granzime B positive, and negative for CD20, CD79a, PAX5, CD163, and myeloperoxidase. This is the first reported case of lymphoma in a bush dog. This report demonstrated the suitability of several cell surface markers for differential diagnosis of round cell tumors in this species.

Cutaneous mast cell tumor in a captive Bush dog (Speothos venaticus): pathological and immunophenotypical aspects - case report

“…To the best of our knowledge, this is the first report of a cutaneous mast cell tumor in a bush dog (Speothos venaticus). The literature on diseases that affect bush dogs is extremely scarce, with rare reports of infectious diseases and only one report of neoplastic disease, namely an extranodal lymphoma affecting an animal from the same institution of the present case (Carvalho et al, 2020). Importantly, this species has a high risk of extinction in the wild and there are only a few individuals in captivity (DeMatteo et al, 2011), which makes the study of diseases in this species particularly important under a perspective of conservation medicine.…”