Eficácia da suplementação oral com 1,3-1,6 betaglucano proveniente de Saccharomyces cerevisiae no controle da mastite bovina

Gimenes, G. C; Dias, Eduardo Herrera; Dias, Silvio Henrique; Bastos, Gabriela Lupepsa; Gerbasi, Adalberto Ramon Valderrama; Almada, André Felipe Berto; Borges, Jessé Lahos; Gonçalves, Daniela Dib; Simões, João Vitor Morais; Júnior, Ranulfo Piau

doi:10.1590/1678-4162-10556

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Probióticos e prebióticos, ou mesmo a combinação desses, atuam como imunomoduladores, estimulando o sistema imune do animal, tornando-o mais resistente e apto a combater infecções (GIMENES et al, 2020). Estudos têm mostrado o efeito de produtos simbióticos na saúde da glândula mamária, melhorando a qualidade do leite (ABDENNEBI et al, 2020;YASUDA et al, 2007).…”

Section: Secagem Dos Tetosunclassified

Saúde da Glândula Mamária de Vacas em Lactação: Revisão de Literatura

et al. 2022

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A mastite é uma infecção da glândula mamária causada por micro-organismos patogênicos, sendo a enfermidade que mais acomete vacas leiteiras causando prejuízos econômicos. Assim, este trabalho teve como objetivo realizar uma revisão bibliográfica sobre a saúde da glândula mamária de vacas em lactação. A mastite pode ser classificada quanto à forma de manifestação, em clínica e subclínica, e quanto ao patógeno causador, em contagiosa e ambiental. Essa doença pode estar associada com a higiene de úbere e pernas das vacas, pois estes estando sujos há maiores chances de sua ocorrência, podendo estar associada também com a hiperqueratose de tetos, pois tetos que contêm hiperqueratose predispõem a ocorrência de infecções intramamárias. A prática mais corriqueira para prevenção da mastite é fazer uso da limpeza e desinfecção dos tetos durante os procedimentos de ordenha. Após uma infecção se instalar, o tratamento comumente utilizado é o uso de antibióticos nos animais, porém a administração desses medicamentos pode gerar riscos tanto à saúde humana quanto para a saúde animal. A utilização de aditivos alimentares de origem biológica como os probióticos e prebióticos, ou mesmo a utilização destes em combinação simbiótica, se apresenta como alternativa ao uso de antibióticos, equilibrando beneficamente o trato gastrointestinal do animal, e atuando como imunomoduladores do sistema imune, tornando-o mais apto a combater infecções. Esta revisão evidencia a importância do conhecimento sobre a mastite bovina, bem como relacionar fatores que influenciam em sua presença, e analisar alternativas de prevenção e controle, que contribuam para melhoria da saúde da glândula mamária. Palavras-chave: Mastite. Vacas Leiteiras. Higiene de Úbere. Hiperqueratose. Abstract Mastitis is an infection of the mammary gland caused by pathogenic microorganisms, being the disease that most affects dairy cows causing economic losses. Thus, this work aimed to carry out a literature review on the mammary gland health of lactating cows. Mastitis can be classified according to the form of manifestation, clinical and subclinical, and the causative pathogen, contagious and environmental. This disease may be associated with hygiene of the udder and legs of cows, as when the same are dirty there is a great chance of occurrence of this disease, and it may also be associated with teat hyperkeratosis, as teats containing hyperkeratosis predispose to the occurrence of infections intramammary. The most common practice for preventing mastitis is to use teat cleaning and disinfection during milking procedures. After an infection sets in, the treatment commonly used is the administration of antibiotics in animals, but this practice can pose risks to both human and animal health. The use of food additives of biological origin such as probiotics and prebiotics, or even the use of symbiotic combinations are alternatives to the use of antibiotics, beneficially balancing the animal’s gastrointestinal tract, and acting as immune system immunomodulators, making it the most capable option to fight infections. This review highlights the importance of knowledge about bovine mastitis, as well as relating factors that influence its presence, and analyzing prevention and control alternatives that contribute to improving the mammary gland health. Keywords: Mastitis. Cairy Cows. Udder Hygiene. Hyperkeratosis.

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Section: Secagem Dos Tetosunclassified

Saúde da Glândula Mamária de Vacas em Lactação: Revisão de Literatura

et al. 2022

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Oral supplementation with yeast β-glucans improves the resolution of Escherichia coli-associated inflammatory responses independently of monocyte/macrophage immune training

et al. 2022

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IntroductionConfronted with the emerging threat of antimicrobial resistance, the development of alternative strategies to limit the use of antibiotics or potentiate their effect through synergy with the immune system is urgently needed. Many natural or synthetic biological response modifiers have been investigated in this context. Among them, β-glucans, a type of soluble or insoluble polysaccharide composed of a linear or branched string of glucose molecules produced by various cereals, bacteria, algae, and inferior (yeast) and superior fungi (mushrooms) have garnered interest in the scientific community, with not less than 10,000 publications over the last two decades. Various biological activities of β-glucans have been reported, such as anticancer, antidiabetic and immune-modulating effects. In vitro, yeast β-glucans are known to markedly increase cytokine secretion of monocytes/macrophages during a secondary challenge, a phenomenon called immune training.MethodsHere, we orally delivered β-glucans derived from the yeast S. cerevisiae to mice that were further challenged with Escherichia coli,Resultsβ-glucan supplementation protected the mice from E. coli intraperitoneal and intra-mammary infections, as shown by a lower bacterial burden and greatly diminished tissue damage. Surprisingly, this was not associated with an increased local immune response. In addition, granulocyte recruitment was transient and limited, as well as local cytokine secretion, arguing for faster resolution of the inflammatory response. Furthermore, ex-vivo evaluation of monocytes/macrophages isolated or differentiated from β-glucan-supplemented mice showed these cells to lack a trained response versus those from control mice.ConclusionIn conclusion, dietary β-glucans can improve the outcome of Escherichia coli infections and dampen tissue damages associated to excessive inflammatory response. The mechanisms associated with such protection are not necessarily linked to immune system hyper-activation or immune training.

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Effect of Saccharomyces cerevisiae byproducts on milk phagocyte function and milk production in mid-lactation cows

Deliberalli,

Abreu,

Milla

et al. 2023

Sem. Ci. Agr.

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Saccharomyces cerevisiae is a supplement option for ruminants due to its ability to stimulate the immune system and productivity; however, there are few studies that demonstrate the effectiveness of this yeast in dairy cattle, especially regarding its effect on milk phagocyte function. Thus, this study examined the effect of two presentations of autolyzed S. cerevisiae on milk phagocyte function and milk production in healthy Holstein cows from the third to the fifth months of lactation with somatic cell count (SCC) less than 200,000 cells mL-1. Ten animals received cell wall-rich S. cerevisiae autolysate (WC 15 g animal day-1); 8 received the cytoplasm-rich extract (CYT 5 g animal day-1) and 7 received a diet without supplementation (C, control) for 60 days. Weekly oxidative metabolism analysis of milk leukocytes, production and milk constituents was carried out. The oxidative metabolism of milk leukocytes was higher in the WC group than in the C group between D32 and D48 (P≤ 0.05) and in the CYT group than in the C group between D24 and D40 (P≤ 0.05). The production and percentage of milk fat increased in CYT at D48 and D56. It is concluded that the CYT group had a greater effect on productivity, while on immunity the effect was intermediate, compared to the WC group, which was efficient in improving the immunity of the mammary gland.

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Eficácia da suplementação oral com 1,3-1,6 betaglucano proveniente de Saccharomyces cerevisiae no controle da mastite bovina

Cited by 3 publications

References 24 publications

Saúde da Glândula Mamária de Vacas em Lactação: Revisão de Literatura

Saúde da Glândula Mamária de Vacas em Lactação: Revisão de Literatura

Oral supplementation with yeast β-glucans improves the resolution of Escherichia coli-associated inflammatory responses independently of monocyte/macrophage immune training

Effect of Saccharomyces cerevisiae byproducts on milk phagocyte function and milk production in mid-lactation cows

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