Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with early stages of mammary carcinoma

Abstract

The aim of this study was to relate the serum concentration IL-6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with and without overweight, and two groups with mammary carcinomas with and without overweight. Overweight bitches, with or without mammary carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (P< 0.0001). There was a positive correlation between ECC and IMCC (P< 0.0001), ECC and % GC (P< 0.0001), and IMCC and % GC (P< 0.0001). A positive correlation was found between serum leptin and IL-6 (P= 0.0451) and leptin and IGF-1 (P= 0.05). A positive correlation (P= 0.0053) between ECC and leptin was found in the analysis of body evaluation methods and serum concentrations, and a negative correlation between ECC and IL-6 (P= 0.0435). Among the fat percentage and the leptin concentration, there was a positive correlation (P= 0.0016), as found between the IMCC and leptin (P= 0, 0209). In this study, no association was observed between excessive weight and the presence of early stage mammary carcinomas.

Tumor mamario canino: factores de riesgo y su influencia epidemiológica en Manizales-Colombia

“…Nuestros resultados concuerdan con estudios previos (11,36,37) y con rangos de edad reportados por diferentes autores, 9 a 11 años (4,20), 6-10 años (9,35), 7-11.9 años (33), 10-11,9 años (34), 8-11 años (32), 8-10 años (13). En particular, la edad de 6 años es conocida como la "edad del cáncer" (1,15,19). Adicionalmente, la incidencia de la enfermedad aumenta con la edad, con picos máximos entre 9 y 10 años (1,35), y disminuye alrededor de los 12 años.…”

“…Las hormonas esteroidales ováricas o productos exógenos, como el acetato de medroxiprogesterona, estimulan la proliferación del tejido mamario, incrementando el riesgo de TMC (8,17,18). Otro factor de relevancia es el sobrepeso y obesidad, que incrementan notablemente el riesgo de TMC (19). Aunque otros autores no hallaron esta asociación (20).…”

“…Aunque otros autores no hallaron esta asociación (20). Una dieta casera rica en grasa es otro factor de riesgo (8,19). Muchos de los anteriores factores de riesgo corresponden con los de humanos, en particular, el estilo de vida, tipo de alimentación/obesidad, y terapias hormonales anticonceptivas (21,22).…”