Um caso raro de destruição total do pâncreas por pancreatite em cão

Camara, B.O.S.; Viana, Fernando Antônio Bretas; Ribeiro, B.N.T.; Ocarino, Natália de Melo; Nepomuceno, Anelise Carvalho; Serákides, Rogéria

doi:10.1590/1678-4162-10103

Cited by 3 publications

(4 citation statements)

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“…Among pancreatic diseases, pancreatitis is the one that most affects the exocrine pancreas of dogs. The disease is characterized by nonspecifi c and intermittent gastrointestinal signs that may hinder the diagnosis [1,2], causing complications such as cell death, reduced blood supply and it might trigger systemic infl ammation, leading to pancreatic dysfunction with a high mortality rate [3,4]. One report mentions a case of pancreatic destruction in a dog, in which it was only possible to fi nd remnants of the parenchyma and infl ammatory cells under the microscope [2].…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Evaluation in Dogs using Different Ultrasonographic Techniques – Preliminary Results

et al. 2020

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AbstractThe aim of this study is to describe the preliminary results on the accuracy of ultrasonographic techniques such as elastography, contrast enhanced ultrasound (CEUS) and Doppler in determining pancreatic changes. Twenty-five dogs, males and females, aged 1-14 years, were studied. Sixteen animals had no clinical signs of pancreatic disease (GS) and nine presented signs of pancreatic disorders (GD). All animals from GD presented sonographic changes in B-mode and qualitative elastography, with shear-wave velocity (SWV) higher (2.4±0.5m/s) in GD (p=0.014) than GS (1.9±0.3m/s) resulting in 78% sensitivity and 69% specificity in the identification of pancreatic changes. Regarding Doppler mode, no differences were observed between groups with color mapping or pulsed wave Doppler. The values obtained with CEUS did not differ between groups. Elastography is a promising technique for differential diagnosis of pancreatic changes because of its sensitivity and specificity, while the other techniques did not show diagnostic accuracy.

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Section: Introductionmentioning

confidence: 99%

Pancreatic Evaluation in Dogs using Different Ultrasonographic Techniques – Preliminary Results

et al. 2020

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“…Quanto ao diabetes mellitus, não foi realizada mensuração de glicemia no paciente, mas não havia presença de glicosúria; além disso, o animal é jovem, sendo o diabetes mellitus foi mais prevalente em cães de 7 a 9 anos em um estudo [12], e foi observada média de idade de 10 anos em outro estudo, sendo raramente observada em cães jovens [20]. Não foram observadas alterações ultrassonográficas de pancreatite, além disso o paciente não apresenta vômitos nem anorexia, sinais geralmente encontrados nessa afecção [4].…”

Section: Discussionunclassified

“…Com base nos valores obtidos na avaliação de triglicerídeos, estabeleceu-se o diagnóstico presuntivo de crises reativas à hiperlipidemia e foi instituído tratamento com bezafibrato 1 [2,5 mg/kg BID], bem como a mudança na dieta com dieta hipocalórica 2 . A dose do fenobarbital 3 foi ajustada para 8 mg/kg/BID e prescreveu-se maleato de enalapril 4 [0,25 mg/kg SID] e bensilato de anlodipino 1 [0,25 mg/kg SID] para controle da hipertensão.…”

Section: Casounclassified

Reactive Seizures Due to Hyperlipidemia in a Maltese Dog

Sales

Picelli

Alves

et al. 2021

Acta Scientiae. Vet.

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Background: Primary hyperlipidemia is a condition that affects some specific breeds. It has been previously described in Miniature Shnauzer, Beagles, Shetland Shepdog and West Highland White Terrier. There are no reports of primary hyperlipidemia in Maltese dogs. It is a hereditary disorder of lipoprotein metabolism. The etiology is unknown and may be related to a genetic problem in lipoprotein lipase or to the absence of apaprotein CII. Clinical signs include spontaneous arterosclerosis, retinal lipemia, cutaneous xanthomas, abdominal pain, lethargy, vomiting and / or diarrhea. Neurological manifestations such as seizures and behavioral changes may also occur. The aim of this report is to describe a case of reactive seizures due to hyperlipidemia in a dog.Case: A 5-year-old male Maltese dog was admitted with a history of seizures. Hypertension and abdominal distension with large amounts of intestinal gases were found in general physical examination. Neurological examination revealed impaired nasal septum sensory perception, which was slightly bilaterally reduced, and pain on cervical palpation and in the brachial plexus region. Based on history and clinical examination, it was possible to locate the lesion in the thalamocortical region and to suspect idiopathic epilepsy, reactive seizures, and symptomatic epilepsy due to meningoencephalitis of unknown origin. The diagnosis of primary hyperlipidemia was made by exclusion with the aid of laboratory tests and ultrasound. After the establishment of a fat restriction diet, bezafibrate, phenobarbital, and omega-3 supplementation, the animal improved significantly with the reduction of epileptic seizures.Discussion: The initial clinical suspicion was hyperadrenocorticism as the primary cause of hyperlipidemia. This suspicion was based on the presence of polyphagia, polydipsia, polyuria and abdominal distension, together with laboratory results of thrombocytosis, increased ALT and AF, and hyposenuria; but ultrasound images and ACTH stimulation test ruled out this differential diagnosis. Hypothyroidism was also ruled out since LDL values were normal and the animal was extremely active. Regarding nephrotic syndrome, it was also excluded for some alterations would be present, such as severe proteinuria, cholesterol reduction and hypoalbuminemia. As for diabetes mellitus, it was discarded because of the dog’s young age and due to the absence of suggestive clinical signs. The suspicion of primary hyperlipidemia was based on increased levels of triglycerides, and the presumptive diagnosis was of reactive seizures due to hyperlipidemia. It is essential, when treating hyperlipidemia, to readjust to a low-calorie diet with fat concentration below 8% and protein level above 18%. Generally, these restricted diets are for life. Omega-3 supplementation can be performed to help maintain low levels of triglycerides. Drug therapy is usually carried out with bezafibrate, which is used in human medicine as treatment for hypertriglyceridemia, and has showed good results in the control of hypertriglyceridemia and hypercholesterolemia in dogs with primary and secondary hyperlipidemia. Six months after the beginning of the treatment, the animal no longer presented abdominal distension and pain, cholesterol values and its fractions were controlled, as well as triglycerides. Seizures were also under control. Therefore, hyperlipidemia is an important differential diagnosis in cases of patients presenting seizures, especially when dealing with young animals showing signs of metabolic diseases.

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“…Nesses casos, contanto que o paciente se recupere, há o retorno histológico e funcional do pâncreas, enquanto que na pancreatite crônica, há mudança histológica permanente e perda progressiva da função exócrina e endócrina, que pode progredir para IPE e/ou DM (Watson, 2003). Câmara et al (2018) relatam um caso de destruição pancreática total causada por pancreatite em um cão, e este também apresentava sinais de diabetes mellitus. No presente caso, nos cortes analisados, não foram notadas a presença das ilhotas de Langerhans.…”

Section: Pubvetunclassified

Pancreatitis esclerosante crónica en un perro: Reporte de un caso

Lemos¹,

Navolar²,

Bracarense³

2021

Pubvet

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Este trabalho tem como objetivo relatar um caso de fibrose pancreática esclerosante em um animal com diabetes mellitus, descrevendo os aspectos clínicos e anatomopatológicos envolvidos na doença em uma cadela, poodle, nove anos, atendida em um Hospital-Escola Veterinário. O animal apresentava picos de hipoglicemia e hiperglicemia, sem resposta ao tratamento insulínico e prognóstico desfavorável. No exame de autópsia, os principais achados anatomopatológicos foram atrofia e fibrose pancreática esclerosante, cistite supurativa e enfisematosa e degeneração hepatocelular gordurosa e glicogênica. Com o auxílio de métodos histoquímicos foi possível identificar a deposição/substituição do interstício pancreático por tecido fibroso.

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Um caso raro de destruição total do pâncreas por pancreatite em cão

Cited by 3 publications

References 14 publications

Pancreatic Evaluation in Dogs using Different Ultrasonographic Techniques – Preliminary Results

Pancreatic Evaluation in Dogs using Different Ultrasonographic Techniques – Preliminary Results

Reactive Seizures Due to Hyperlipidemia in a Maltese Dog

Pancreatitis esclerosante crónica en un perro: Reporte de un caso

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