Alprostadil associated with low molecular weight heparin to treat limb ischemia caused by SARS-CoV2

Abstract

The current coronavirus pandemic has already taken a great toll globally, causing massive morbidity and mortality. One of its severe forms is a thrombophilic state that can damage several systems. This article reports the case of 60-year-old female patient who presented with mild flu symptoms, which turned out to be a SARS-CoV2 infection, and ended up developing arterial thrombosis with limb ischemia in a private care hospital in Sorocaba, São Paulo, Brazil. Considering this progression, we decided to intervene with low molecular weight heparin and Alprostadil, achieving a good clinical outcome. Our description aims to identify key points and clinical signs that offer evidence of the therapeutic window and a treatment option for coagulatory presentations of COVID-19.

Isquemia arterial aguda de membros superiores em pacientes diagnosticados com COVID-19: série de casos

“…There is also a case report of their use in the context of COVID-19. 18 , 19 In the cases presented here, improvements in pain were observed after introduction of alprostadil, without adverse reactions.…”

“…O uso de prostanoides em casos de isquemia crítica sem condições de revascularização é descrito na literatura, havendo relatos prévios de bons resultados na melhora da dor e pequeno efeito favorável na cicatrização de feridas. Além disso, há relato de caso de seu uso no contexto da COVID-19 18 , 19 . Nos casos apresentados, foi observado melhora das queixas álgicas após a introdução de alprostadil, sem reações adversas.…”