HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters

Barbalho, Sandra Maria; Tofano, Ricardo José; Oliveira, Marcela Bueno de; Quesada, Karina; Barion, Mariana Ricci; Akuri, Marina Cristina; Oshiiwa, Marie; Bechara, Marcelo Dib

doi:10.1590/1677-5449.180109

Cited by 23 publications

(14 citation statements)

References 21 publications

(47 reference statements)

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“…In addition, the relationships between these biomarkers and weight have also been shown in many cross-sectional and cohort studies. [17][18][19] However, most prospective studies have focused on the effects of weight gain on these biochemical indices, [20][21][22] but whether changes in blood lipids predict weight gain remains unclear. In a limited number of studies, the role of blood lipids in predicting overweight/obesity has been inconsistent due to differences in subject characteristics and follow-up period.…”

Section: Introductionmentioning

confidence: 99%

Transition Patterns of Weight Status and Their Predictive Lipid Markers Among Chinese Adults: A Longitudinal Cohort Study Using the Multistate Markov Model

Tang¹,

Hong-ya²,

Zhao³

et al. 2021

DMSO

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Background Obesity is well recognized as a risk factor for cardiometabolic diseases. The development of obesity is a dynamic process that can be described as a multistate process with an emphasis on transitions between weight states. However, it is still unclear what convenient biomarkers predict transitions between weight states. The aim of this study was to show the dynamic nature of weight status in adults stratified by age and sex and to explore blood markers of metabolic syndrome (MetS) that predict transitions between weight states. Methods This study involved 9795 individuals aged 18 to 56 at study entry who underwent at least two health check-ups in the eight-year period of study in the health check-up centre of our institution. Weight, height and biochemical indices were measured at each check-up. The participants were divided into four groups based on age and sex (young male, middle-aged male, young female and middle-aged female groups). A multistate Markov model containing 3 states (healthy weight, overweight and obesity) was adopted to study the longitudinal weight data. Results Young people were more likely to transit between weight states than middle-aged people, and middle-aged people were more resistant to recover from worse states. The mean sojourn time in obesity was greatest in the middle-aged male group (6.23 years), and the predicted rate of obesity beginning with healthy weight was greatest in the young male group (13.7%). In multivariate models, age group and triglyceride (TG) and high-density lipoprotein cholesterol (HDL) levels were significant for specific transitions in females, whereas age group and HDL levels were significant in males. In females, if HDL levels increased 1 mmol/L, the probability of progression from healthy weight to overweight decreased by 37.0% (HR= 0.63), and the probabilities of recovery (overweight to healthy weight and obesity to overweight) increased by 62.0% (HR= 1.62) and 1.23-fold (HR= 2.23), respectively. In males, if TG levels increased 1 mmol/L, the risk of progression from healthy weight to overweight increased by 24.0% (HR= 1.24). Each unit increase in HDL levels was associated with a 0.99-fold (HR= 1.99) increase in the chance of recovery from overweight to healthy weight and with a 0.37-fold (HR= 0.63) decrease in the risk of progression from healthy weight to overweight. Conclusion The weight status of young people was less stable than that of middle-aged people. Males were more likely to become overweight and more resistant to recover from worse states than females. Young males with healthy weight were more likely to develop obesity than other healthy weight groups. Blood lipid levels, especially HDL, were predictors of weight transitions in adults. Prevention and intervention measures should be applied early.

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Section: Introductionmentioning

confidence: 99%

Transition Patterns of Weight Status and Their Predictive Lipid Markers Among Chinese Adults: A Longitudinal Cohort Study Using the Multistate Markov Model

Tang¹,

Hong-ya²,

Zhao³

et al. 2021

DMSO

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“…Studies showed that HDL-C neither has any protective function nor re ects the functionality of HDL-C. Therefore HDL-C protection is still controversial [20] . Studies proved that the LDL-C/HDL-C was closely related to the onset of CHD and the progression of atherosclerosis [21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

LDL-C/HDL-C and carotid plaques in patients with coronary heart disease: A Chinese cohort study

Cheng

Yi-jia

et al. 2021

Preprint

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Background: Evidence of the association the low-/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) with the carotid plaques remains limited. The purpose of this study is to examine the association between LDL-C/HDL-C and carotid plaques of coronary heart disease (CHD), and to study what extent a healthy lifestyle reduces the risk of carotid plaques.Methods: In this large-scale and multi-center retrospective study, a total of 9,426 participants to explore the association between LDL-C/HDL-C and carotid plaques. No smoking and no drinking were considered healthy lifestyle. Generalised estimating equation models and conditional logistic regressions were used in statistical analyses.Results: In all the 9,426 participants, there were 6,989 (74.15%) patients having identified carotid plaques. High levels of LDL-C/HDL-C had a higher risk of carotid plaques than other lipid variables (OR:1.63; 95%CI:1.43-1.86). In stratified analyses by LDL-C/HDL-C triplet, participants in the LDL-C/HDL-C (＞3mmol/L) group had a higher risk of carotid plaques compared to other two groups. Compared with the unfavourable lifestyle, intermediate lifestyle or favourable lifestyle was associated with a significant 30% or 67% decrease in carotid plaques risk among patients with the LDL-C/HDL-C(＞3mmol/L) respectively. There were significantly additive and multiplicative interactions between lifestyle and LDL-C/HDL-C on carotid plaques.Conclusion: Our findings provide evidence that a high level of LDL-C/HDL-C can increase the risk of carotid plaques in patients with CHD. And adhering to a healthy lifestyle has additive beneficial effects on reducing the risk of carotid plaques.

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“…Although it is a process with a high degree of uncertainty and low predictability of results, it is possible and necessary to manage the PDP, planning, executing, controlling and improving activities, in search of better performance and learning results that together competitiveness (JUGEND, 2006). However, mechanisms that include improvements in the PDP and application of reference models are complex for the literature of the area and for the companies (ROZENFELD et al, 2006;BARBALHO;ROZENFELD, 2013;BERGAMO;ROMANO, 2016;.…”

Section: Independent Journal Of Management and Production (Ijmandp)mentioning

confidence: 99%

“…In addition, it is verified that the PDP's initial vision with emphasis on linear activities, characteristics of development macrophases, adopts the PDP vision as a business process, that is, align the PDP with the company's strategic planning, integrating all the its internal and external areas. With respect to the particularities, perceptions of improvements in the PDP in recent years are being developed for specific market segments (COLENCI NETO, 2008;CAMPOS;RIBEIRO, 2011;BARBALHO;ROZENFELD, 2013;ROMANO, 2013;COSTA;TOLEDO, 2013;MORETTI;BRAGHINI JUNIOR, 2017). However, they use as basis for development the generalist model of Rozenfeld et al (2006).…”

Section: Independent Journal Of Management and Production (Ijmandp)mentioning

confidence: 99%

Systematic analysis of reference models in product development: case studies in the agricultural machinery and implementation sector

Silveira

Machado

Ruppenthal

et al. 2018

Ind. Jour. Manag. & Prod.

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With the growth in the machinery and agricultural implements sector the importance of the area of Product Development Process (PDP) has expanded significantly in the last decades. The surge is due to increased competition among manufacturers, thus requiring high quality products with greater efficiency in their production processes.In addition, the management of the phases that comprise the PDP is considered complex by specialized literature and manufacturing companies. Thus, the objective of the study is to present the main reference models that contextualize the PDP in order to systematically analyze its methodological classifications.In addition, the research seeks to explore the work methodologies currently applied in the PDP of the agricultural machinery and implements manufacturers located in the northwestern region of Rio Grande do Sul -Brazil. The research adopted the Systematic Literature Review (SLR) and the case study as investigation methods, classified as descriptive and comparative, of an exploratory nature. As a result, it was possible to identify a set of reference models that are usually adopted to operationalize the PDP. Research has shown that project support tools are not used by companies, while design and industrial management tools are applied. Finally, it was verified that companies have little knowledge about reference models.

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HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters

Cited by 23 publications

References 21 publications

Transition Patterns of Weight Status and Their Predictive Lipid Markers Among Chinese Adults: A Longitudinal Cohort Study Using the Multistate Markov Model

Transition Patterns of Weight Status and Their Predictive Lipid Markers Among Chinese Adults: A Longitudinal Cohort Study Using the Multistate Markov Model

LDL-C/HDL-C and carotid plaques in patients with coronary heart disease: A Chinese cohort study

Systematic analysis of reference models in product development: case studies in the agricultural machinery and implementation sector

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