2014
DOI: 10.1590/1677-3225v13n3a15
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Abstract: Aim: To evaluate antimicrobial ability of neem leaf extract, 3% sodium hypochlorite (NaOCl) and 2% chlorhexidine (CHX) against Candida albicans. Methods: Neem leaf extract was prepared by using absolute ethanol with fresh neem leaves, filtering the extract through muslin cloth, coarse residue and filter paper. Cultures of C. albicans were maintained on Brain Heart Infusion broth and Agar. The antimicrobial efficacy was checked using the Agar Diffusion and the zones of inhibition were measured. The results were… Show more

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Cited by 10 publications
(6 citation statements)
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“…[ 21 ] However, it has been reported that antifungal drugs have some toxic effects on the patient if it is overused; hence, the plant extracts neem ( A. indica ) and garlic ( A. sativum ) which are naturally available and also possess antifungal property can be used for the same. [ 4 14 22 23 24 25 26 27 ] This leads to the microbiological investigation conducted in this study, which confirms that the released concentrations of the antifungal agents (plant extracts) from the soft lining materials were able to induce an antifungal effect against C. albicans on agar culture. Furthermore, the changes in any hardness of the denture base after the incorporation of the plant extracts were analyzed.…”
Section: Discussionsupporting
confidence: 71%
“…[ 21 ] However, it has been reported that antifungal drugs have some toxic effects on the patient if it is overused; hence, the plant extracts neem ( A. indica ) and garlic ( A. sativum ) which are naturally available and also possess antifungal property can be used for the same. [ 4 14 22 23 24 25 26 27 ] This leads to the microbiological investigation conducted in this study, which confirms that the released concentrations of the antifungal agents (plant extracts) from the soft lining materials were able to induce an antifungal effect against C. albicans on agar culture. Furthermore, the changes in any hardness of the denture base after the incorporation of the plant extracts were analyzed.…”
Section: Discussionsupporting
confidence: 71%
“…The studies on the comparative evaluation of methanolic and ethanolic extracts of A . indica A. juss ( Neem ), NaOCl and CHX as root canal irrigants were tabulated [ Table 1 ] The in-vitro studies[ 16 17 18 19 20 21 22 23 24 25 ] compared the antimicrobial activity of ethanolic and methanolic extracts of A. indica A. juss (Neem) to varying concentrations of NaOCl (2%, 2.5%, 3%, 5%) and CHX (0.25%, 0.5%, 2%) against Enterococcus faecalis ( E. faecalis ) and Candida albicans ( C. albicans ). In all of these studies, Neem performed equally well as NaOCl without showing any toxicity as compared to NaOCl when used at lower concentrations.…”
Section: Resultsmentioning
confidence: 99%
“…Abidin et al described that the mechanism of action of an intracanal medicament made from natural extracts was predominantly on the cell membrane by disrupting its structure, blocking membrane synthesis, and inhibition of cellular respiration thereby causing cell leakage and cell death. 8 An ideal intracanal medicament should possess maximal antimicrobial and tissue solving properties and minimal toxic effects. E. faecalis is a gram-positive and a facultative anaerobe.…”
Section: Discussionmentioning
confidence: 99%