Influence of ovariectomy combined with lack of masticatory force in the evolution of periodontal disease

Milhan, Noala Vicensoto Moreira; Forte, Lilibeth Ferraz de Brito Penna; Vasconcelos, Luana Marotta Reis de; Balducci, Ivan; Carvalho, Yasmin Rodarte

doi:10.1590/1677-3225v13n1a10

Cited by 1 publication

(2 citation statements)

References 25 publications

(35 reference statements)

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“…However, others studies on humans have shown no relation between periodontal disease and alcohol intake [9][10] . The effects of alcohol on periodontal disease exist and this relation has been explained by biological plausibility through different mechanisms.…”

Section: Discussionmentioning

confidence: 98%

“…However, more recent studies on humans have shown no relation between periodontal disease and alcohol consumption [6][7] . The use of rat models has been applied in the evaluation of periodontal pathogenesis 8 and regarding the influence of risk indicator/factors, such as estrogen deficiency [9][10] , alcohol consumption [11][12][13][14][15][16] , nicotine 17 and simultaneous nicotine and alcohol use 18 on disease progression.…”

Section: Introductionmentioning

confidence: 99%

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Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Souza¹,

Ricardo²,

Rocha³

2014

Braz. J. Oral Sci.

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Aim: To evaluate histometrically the effect of low and high caloric value of ethanol on ligatureinduced bone loss in female rats. Methods: Sixty female rats were divided into five groups of 12 animals each: Normal Control (water), Test A (low ethanol), Control A (low iso), Test B (high ethanol) and Control B (high iso). Control Groups A and B received diets with the same amount of calories consumed by Test Groups A and B, respectively, with ethanol replaced by isocaloric amounts of carbohydrate. Four weeks prior to the end of the experimental period, half of the rats in each group were randomly assigned to receive a ligature on mandibular molar, whereas the other half of group was left unligated. At 8 weeks, the animals were sacrificed, and the specimens were processed to obtain decalcified sections. The area of periodontal ligament and/or bone loss in the furcation region of the first molars was histometrically measured in five sections per specimen (mm²). Results: Ethanol intake did not have effect on the alveolar bone loss in unligated teeth (p>0.05). However, in ligature-induced periodontitis, high value of calories associated with ethanol feeding enhanced the area of bone loss (p<0.05). Conclusions: The results of this study demonstrated that a low-ethanol diet did not affect the periodontium, while a high-ethanol diet may aggravate the progression of periodontitis, as demonstrated by the increased furcation region bone destruction in periodontal disease.

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Section: Discussionmentioning

confidence: 98%