Effects of Gundelia tournefortii L. on biochemical parameters, antioxidant activities and DNA damage in a rat model of experimental obesity

Abstract

The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms of DNA damage, biochemical and antioxidant parameter values in rats with high-calorie diets. With this aim, Wistar albino male rats were divided into 4 groups containing 6 rats each and the study was completed over 12 weeks duration. At the end of the implementation process over the 12 weeks, rats were sacrificed and blood and tissue samples were obtained. Analyses were performed on blood and tissue samples. According to results for DNA damage (8-OHdG), in brain tissue the OG2 group was significantly reduced compared to the NC group. For MDA results in liver tissue, OG1 and OG2 groups were determined to increase by a significant degree compared to the control group, while the OG2 group was also increased significantly compared to the obese group. In terms of the other parameters, comparison between the groups linked to consumption of a high calorie diet (HCD) and administration of Gundelia tournefortii L. in terms of antioxidant activities and serum samples obtained statistically significant results. Gundelia tournefortii L. plant extracts had effects that may be counted as positive on antioxidant parameter activity and were especially identified to improve DNA damage and MDA levels in brain tissues. Additionally, consumption of Gundelia tournefortii L. plant extract in the diet may have antiobesity effects; thus, it should be evaluated for use as an effective weight-loss method and as a new therapeutic agent targeting obesity.

Determination Effects of Rheum ribes L. against High Calorie Diet-induced Obesity: Investigation of Changes in Immunologic and Neurologic Enzymes Activities

“… Normal Control group (CG); normal rat food  HCD Control group (HCDG); high calorie rat food  HCD+ Rr group (HCDRHE1); High calorie rat food + Rr plant extract (200 mg/kg)  HCD+ Rr group (HCDRHE2); High calorie rat food + Rr plant extract (400 mg/kg) In the 56th day of the study, body mass index (BMI) was calculated for the subjects in both groups (Altunkaynak et al, 2008;Bati et al, 2021). As a result of the calculation, the groups consuming HCD feed were obese, and at the end of the 56th day, in addition to the HCD feed, the plant extract was given to the HCDRHE1 and HCDRHE2 groups by oral gavage (OECD, 2008).…”