2023
DOI: 10.1590/1519-6984.244977
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Abstract: Hepatitis C virus (HCV) is the serious global public health burden of liver disease. Approximately 170 million people in the world are infected with (HCV). In Pakistan, where the disease has high occurrence rate. The present study envisages an up-to-date prevalence of HCV and genotypic distribution in the general population of Mardan District, Khyber Pakhtunkhwa (KP), Pakistan. The blood samples from 6,538 individuals including 3,263 males and 3,275 females were analyzed for hepatitis C surface antigen by Immu… Show more

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Cited by 8 publications
(3 citation statements)
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References 46 publications
(48 reference statements)
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“…Data analysis demonstrated that the HCV genotype 3 was more frequent in females (70.8%) than in males (68.9%). These results are in compliance with the outcomes of previous studies conducted in different regions of the country, which also indicated HCV 3 genotype to be the most prevalent genotype reported [16]. Other Asian countries (e.g., India and Nepal) also showed a similar prevalence pattern with a higher frequency of HCV genotype 3 [17], whereas South Asian Countries (e.g., Vietnam, Thailand, and Japan) indicated a different pattern with HCV genotype 1a being the most prevalent genotype [18].…”
Section: Discussionsupporting
confidence: 92%
“…Data analysis demonstrated that the HCV genotype 3 was more frequent in females (70.8%) than in males (68.9%). These results are in compliance with the outcomes of previous studies conducted in different regions of the country, which also indicated HCV 3 genotype to be the most prevalent genotype reported [16]. Other Asian countries (e.g., India and Nepal) also showed a similar prevalence pattern with a higher frequency of HCV genotype 3 [17], whereas South Asian Countries (e.g., Vietnam, Thailand, and Japan) indicated a different pattern with HCV genotype 1a being the most prevalent genotype [18].…”
Section: Discussionsupporting
confidence: 92%
“…Although the precise reasons for this difference are unclear, environmental exposures and lifestyle, such as male homosexuality, sharing of needles used for drug injection, receiving tattoos, and alcohol consumption, may make men more likely to be infected with HCV. [29] In addition, some studies suggest that women have higher rates of viral clearance and a better response to HCV treatment than men. [30] HCV subtypes GT3a and GT3b are more prevalent in men than in women.…”
Section: Discussionmentioning
confidence: 99%
“…Hepatitis C virus (HCV) is a major serious global health issue, with approximately 70 million people currently infected 1,2 . HCV‐related cirrhosis or hepatocellular carcinoma (HCC) results in the death of over 350,000 patients 3 .…”
Section: Introductionmentioning
confidence: 99%